Genetic disruption of 2-arachidonoylglycerol synthesis reveals a key role for endocannabinoid signaling in anxiety modulation

Shonesy, Brian C., Bluett, Rebecca J., Ramikie, Teniel S., Báldi, Rita, Hermanson, Daniel J., Kingsley, Philip J., Marnett, Lawrence J., Winder, Danny G. +2 more·2014·Cell Reports
DOI 10.1016/j.celrep.2014.11.001

Cited by (156)

Items 101–156 of 156

  1. Contribution of diacylglycerol lipase β to pain after surgery
    Jennifer Luk, Yong Lu, Amanda Ackermann, Xiaoxue Peng, Diane Bogdan, Michelino Puopolo, David E. Komatsu, Simon Tong, Iwao Ojima, Mario J. Rebecchi et al. · 2018 · Journal of Pain Research
  2. Ventral hippocampal diacylglycerol lipase-alpha deletion decreases avoidance behaviors and alters excitation-inhibition balance
    Veronika Kondev, Rebecca J. Bluett, Mustafa Najeed, Luis E. Rosas-Vidal, Brad A. Grueter, Sachin Patel · 2022 · Neurobiology of Stress
  3. Neuronal protein-tyrosine phosphatase 1B hinders sensory-motor functional recovery and causes affective disorders in two different focal ischemic stroke models
    Alexandre F.R. Stewart, Hsiao‐Huei Chen, Shelly Abad Cruz, Zhaohong Qin, Konrad M. Ricke · 2020 · Neural Regeneration Research
  4. Monoacylglycerol lipase alpha inhibition alters prefrontal cortex excitability and blunts the consequences of traumatic stress in rat
    Nicholas B. Worley, J.A. Varela, G.P. Gaillardetz, Matthew N. Hill, John P. Christianson · 2020 · Neuropharmacology
  5. From Classical to Alternative Pathways of 2-Arachidonoylglycerol Synthesis: AlterAGs at the Crossroad of Endocannabinoid and Lysophospholipid Signaling
    Fabienne Briand‐Mésange, Isabelle Gennero, Juliette Salles, Stéphanie Trudel, Lionel Dahan, Jérôme Ausseil, Bernard Payrastre, Jean‐Pierre Salles, Hugues Chap · 2024 · Molecules
  6. Circuit mechanisms governing endocannabinoid modulation of affective behaviour and stress adaptation
    Niharika Loomba, Sachin Patel · 2025 · Nature reviews. Neuroscience
  7. Quantal size increase induced by the endocannabinoid 2‐arachidonoylglycerol requires activation of CGRP receptors in mouse motor synapses
    Ekaterina Tarasova, Polina O. Bogacheva, Kirill Chernyshev, Olga P. Balezina · 2023 · Synapse
  8. Endocannabinoid Gene × Gene Interaction Association to Alcohol Use Disorder in Two Adolescent Cohorts
    Laurent Elkrief, Sean Spinney, Daniel E. Vosberg, Tobias Banaschewski, Arun L.W. Bokde, Erin Burke Quinlan, Sylvane Desrivières, Herta Flor, Hugh Garavan, Penny Anne Gowland et al. · 2021 · Frontiers in Psychiatry
  9. The Anxiolytic Actions of 2-Arachidonoylglycerol: Converging Evidence From Two Recent Genetic Endocannabinoid Deficiency Models
    Sachin Patel, Brian C. Shonesy, Rebecca J. Bluett, Danny G. Winder, Roger J. Colbran · 2015 · Biological Psychiatry
  10. Effects of fecal microbiota transplantation from patients with generalized anxiety on anxiety-like behaviors: The role of the gut-microbiota-endocannabinoid-brain Axis
    Min Cai, Shan‐Shan Xue, Cuihong Zhou, Yuchao Feng, Jiangzheng Liu, Rui Liu, Peng Wang, Huaning Wang, Zhengwu Peng · 2025 · Journal of Affective Disorders
  11. SGIP1 in axons prevents internalization of desensitized CB1R and modifies its function
    Oleh Durydivka, Ken Mackie, Jaroslav Blahoš · 2023 · Frontiers in Neuroscience
  12. Identification of DAGLA as an autoantibody target in cerebellar ataxia
    Ramona Miske, Madeleine Scharf, Kathrin Borowski, Ina Specht, Merle Corty, Monika-Johanna Loritz, Frederik Rombach, Guy Laureys, Nadine Rochow, Christiane Radzimski et al. · 2024 · Journal of Neurology Neurosurgery & Psychiatry
  13. Endocannabinoid biosynthetic enzymes regulate pain response via LKB1–AMPK signaling
    Miaomiao Chen, Myungsun Shin, Timothy B. Ware, Giulia Donvito, Karan H. Muchhala, Ryan A. Mischel, Mohammed Ahmed Mustafa, Vlad Serbulea, Clint M. Upchurch, Norbert Leitinger et al. · 2023 · Proceedings of the National Academy of Sciences
  14. NCK1 Regulates Amygdala Activity to Control Context-dependent Stress Responses and Anxiety in Male Mice
    Antonios M. Diab, Jiansong Qi, Ibrahim Shahin, Crystal Milligan, James P. Fawcett · 2020 · Neuroscience
  15. Lack of β2-AR Increases Anxiety-Like Behaviors and Rewarding Properties of Cocaine
    Huiwen Zhu, Zhiyuan Liu, Yiming Zhou, Xu-Ming Yin, Bo Xu, Lan Ma, Xing Liu · 2017 · Frontiers in Behavioral Neuroscience
  16. Broad and Region-Specific Impacts of the Synthetic Cannabinoid CP 55,940 in Adolescent and Adult Female Mouse Brains
    Emma Leishman, Michelle N. Murphy, Michelle I. Murphy, Ken Mackie, Heather B. Bradshaw · 2018 · Frontiers in Molecular Neuroscience
  17. Gene expression in the primate orbitofrontal cortex related to anxious temperament
    Margaux M. Kenwood, Tade Souaiaia, Rothem Kovner, Andrew S. Fox, Delores A. French, Jonathan A. Oler, Patrick H. Roseboom, Marissa K. Riedel, Sascha A. L. Mueller, Ned H. Kalin · 2023 · Proceedings of the National Academy of Sciences
  18. Parental Influences on Adolescent Major Depressive Symptoms and Marijuana Use
    Andrea L. Ruybal, William D. Crano · 2020 · International Journal of Mental Health and Addiction
  19. Cannabinoid type 1 receptors in A2a neurons contribute to cocaine-environment association
    Brandon D. Turner, Nicholas K. Smith, Kevin M. Manz, Betty T. Chang, Eric J. Delpire, Carrie A. Grueter, Brad A. Grueter · 2021 · Psychopharmacology
  20. Effects of waterpipe tobacco smoke and ceftriaxone treatment on the expression of endocannabinoid receptors in mesocorticolimbic brain regions
    Alaa M. Hammad, Sara Jamal Meknas, Frank Scott Hall, Suhair Hikmat, Youssef Sari, T.M. Al-Qirim, Malek Alfaraj, Haneen A. Amawi · 2022 · Brain Research Bulletin
  21. Imaging and Genetic Tools for the Investigation of the Endocannabinoid System in the CNS
    Armin Kouchaeknejad, Gunter van der Walt, Maria Helena de Donato, Emma Puighermanal · 2023 · International Journal of Molecular Sciences
  22. Pharmacological diacylglycerol lipase inhibition impairs contextual fear extinction in mice
    Liorimar Ramos-Medina, Luis E. Rosas-Vidal, Sachin Patel · 2024 · Psychopharmacology
  23. Endocannabinoid system in trauma and psychosis: distant guardian of mental stability
    Tomasz Bielawski, Lucas Albrechet‐Souza, Dorota Frydecka · 2021 · Reviews in the Neurosciences
  24. Anti-aversive effect of 2-arachidonoylglycerol in the dorsolateral periaqueductal gray of male rats in contextual fear conditioning and Vogel tests
    Rayssa C. Brianis, Rita C. Lima, Fabrício A. Moreira, Daniele C. Aguiar · 2021 · Behavioural Pharmacology
  25. Inhibition of diacylglycerol lipase α induced blood–brain barrier breach in female Sprague–Dawley rats
    Erika Liktor‐Busa, Aidan A. Levine, Sally J. Young, Colin Bader, Seph M. Palomino, Felipe D. Polk, Sarah A. Couture, Paulo Wagner Pires, Trent R. Anderson, Tally M. Largent‐Milnes · 2025 · The Journal of Physiology
  26. Suppression of pain transmission and behavior by inhibition of peripheral diacylglycerol metabolism
    Yusuf Tufail, Carlos Guijas, David A. Kummer, Cassandra L. Henry, Jeanne Moody, Taylor Andalis, Bryan Boyd, Jacob Gil, Jacquelyn Ha, Dylan M. Herbst et al. · 2026 · Cell chemical biology
  27. Differential roles of diacylglycerol lipase (DAGL) enzymes in nicotine withdrawal
    Belle Buzzi, Eda Köşeli, Yasmin Alkhlaif, Abigail Parker, Mohammed Ahmed Mustafa, Aron H. Lichtman, Matthew W. Buczynski, Mohamad Imad Damaj · 2023 · Brain Research
  28. Peripheral Endocannabinoid Components and Lipid Plasma Levels in Patients with Resistant Migraine and Co-Morbid Personality and Psychological Disorders: A Cross-Sectional Study
    Sara Bottiroli, Rosaria Greco, Valentina Franco, Annamaria Zanaboni, Michela Palmisani, Gloria Vaghi, Grazia Sances, Roberto De Icco, Cristina Tassorelli · 2024 · International Journal of Molecular Sciences
  29. Neonatal dysregulation of 2-arachidonoylglycerol induces impaired brain function in adult mice
    Kyung-Jun Boo, Dae‐Hyun Kim, Eunbi Cho, Dong Hyun Kim, Se Jin Jeon, Chan Young Shin · 2024 · Neuropharmacology
  30. Endocannabinoids, Stress, and Negative Affect
    Anthony L. Berger, Angela M. Henricks, Matthew N. Hill, Ryan J. McLaughlin · 2017 · Springer eBooks
  31. Astrocytic Dagla Deletion Decreases Hedonic Feeding in Female Mice
    Este Leidmaa, Alexandra Maria Prodan, Lena-Louise Depner, Joanna Agnieszka Komorowska‐Müller, Eva Carolina Beins, Britta Schürmann, Carl‐Christian Kolbe, Andreas Zimmer · 2024 · Cannabis and Cannabinoid Research
  32. Marijuana, a Journey through the Endocannabinoid System: Unmasking the Paradoxical Effect - Part 1
    Ryan Lucas McKinley · 2022 · Biochemistry
  33. Genetic Tools in Rodents to Study Cannabinoid Functions
    Krisztina Monory, Iñigo Ruı́z de Azúa, Beat Lutz · 2024 · Current topics in behavioral neurosciences
  34. Reply to: The Anxiolytic Actions of 2-Arachidonoylglycerol: Converging Evidence From Two Recent Genetic Endocannabinoid Deficiency Models
    Imke Jenniches, Andreas Zimmer · 2015 · Biological Psychiatry
  35. 2-Arachodonoylglycerol-mediated endocannabinoid signaling modulates mechanical hypersensitivity associated with alcohol withdrawal in mice
    Amanda Morgan, Danielle N. Adank, Keenan Johnson, Emily Blunt, Sachin Patel · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  36. DAGLα/β, 2-AG release, and Parkinson’s Disease: Exploring a causal link
    Patrick Doherty, Gareth Haydn Williams · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  37. Behavioral Decoding Reveals Cortical Endocannabinoid Potentiation during Δ 9 -THC Impairment
    Anthony English, David J. Marcus, Khushi Yadav, Yassin Elkhouly, Allan Levy, Victoria L. Corbit, M. Ask, Anika Scedberg, Jordan Poces-Ball, Fleur Uittenbogaard et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  38. Design, synthesis, methodology development, and evaluation of PET imaging agents targeting cancer and CNS disorders
    Gengyang Yuan · 2017
  39. Targeting Diacylglycerol Lipase to Reduce Alcohol Consumption
    Gaurav Bedse, Nathan D. Winters, Anastasia A. Astafyev, Toni A. Patrick, Vikrant R. Mahajan, Md. Jashim Uddin, Samuel W. Centanni, David C. Samuels, Lawrence J. Marnett, Danny G. Winder et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  40. Faculty Opinions recommendation of Upregulation of Anandamide Hydrolysis in the Basolateral Complex of Amygdala Reduces Fear Memory Expression and Indices of Stress and Anxiety.
    Linda A. Parker · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  41. Faculty Opinions recommendation of Role of Striatal Direct Pathway 2-Arachidonoylglycerol Signaling in Sociability and Repetitive Behavior.
    Giovanni Marsicano, Arnau Busquets-García · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  42. Deletion of endocannabinoid synthesizing enzyme DAGLα from cerebellar Purkinje cells decreases social preference and elevates anxiety
    Gabriella Smith, Kathleen McCoy, Gonzalo Viana Di Prisco, Alexander Kuklish, Emma Grant, Mayil Bhat, Sachin Patel, Ken Mackie, Brady K. Atwood, Anna Kalinovsky · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  43. Anandamide and mood disorders
    Jacklynn M. Fitzgerald, Cecilia J. Hillard · 2024 · Elsevier eBooks
  44. Impact of Stress on the Endocannabinoid System: A [ 11 C]-CURB Positron Emission Tomography Study in Early Psychosis: Les effets du stress sur le système endocannabinoïde : étude par tomographie par émission de positons avec l’indicateur radioactif [11C-CURB] dans la psychose précoce
    Ana Weidenauer, Ranjini Garani Ramesh, Paula Campos Oller, Maira Belén Blasco, Pablo Rusjan, Romina Mizrahi · 2024 · The Canadian Journal of Psychiatry
  45. Mood, Motivation, and Mental Health
    Jean-Paul Henri Dedam, Matthew Fogel, Elizabeth Fogel · 2025 · Springer eBooks
  46. Deletion of Endocannabinoid Synthesizing Enzyme DAGLα in Pcp2-Positive Cerebellar Purkinje Cells Decreases Depolarization-Induced Short–Term Synaptic Plasticity, Reduces Social Preference, and Heightens Anxiety
    Gabriella Smith, Kathleen McCoy, Gonzalo Viana Di Prisco, Alexander Kuklish, Emma Grant, Mayil Bhat, Sachin Patel, Ken Mackie, Brady K. Atwood, Anna Kalinovsky · 2025 · eNeuro
  47. Overview of the Endogenous Cannabinoid Signaling System
    Todd M. Stollenwerk, César E. Martinez Ramirez, Cecilia J. Hillard · 2025 · Springer eBooks
  48. Molecular Dynamics in the Ventral Tegmental Area during Chronic Pain-Induced Negative Affect
    Cody C. Diezel, Lisa A. Majuta, Erfan Bahramnejad, Kelly L. Karlage, Jennifer L. Partin, Saniya M.D. Barbour, Ingrid L. Peterson, Matthew Flowers, Sophia T. von Hippel, Riley Haveman et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  49. Endocannabinoids and the neurobiology of emotional states
    Gavin N. Petrie, Abigail R. Lunge, Leah M. Mayo, Matthew N. Hill · 2025 · Handbook of behavioral neuroscience
  50. FIGURES 45. Axinyssa djiferi spec. nov. 4 in A new species of Axinyssa Lendenfeld, 1897 (Porifera, Demospongiae, Halichondrida) from the Senegalese coast
    Nicole Boury‐Esnault, Christian Marschal, Probst, Jean-Michel Korn-, Gilles Barnathan · 2002 · INFM-OAR (INFN Catania)
  51. Identifying therapeutic targets for the treatment of Fragile X Syndrome : Implications for Autism Spectrum Disorders
    William Fyke · 2021
  52. Sterol carrier protein 2 loss reduces anxiety and enhances fear extinction
    Elizabeth Sabens Liedhegner, Kara L. Stuhr, Elizabeth M. Doncheck, Jennifer A Tinklenberg, Samantha Pollock, Jennifer Sterrett, Ozge Gunduz‐Cinar, Cecilia J. Hillard · 2026 · Journal of Affective Disorders
  53. Exploring sex differences in endocannabinoid system biomarkers and their relationship with antidepressant treatment outcomes in major depressive disorder: a CAN-BIND 1 secondary analysis
    Maryam Sorkhou, Helena Kyunghee Kim, Faranak Farzan, Jane A. Foster, Benicio Noronha Frey, Muhammad Ishrat Husain, Sidney H. Kennedy, Raymond Wing Moon Lam, Roumen V. Milev, Benoit H. Mulsant et al. · 2026 · European Archives of Psychiatry and Clinical Neuroscience
  54. Cannabidiol and neural correlates of threat anticipation in alcohol use disorder
    Tristan P. Hurzeler, Warren Logge, Joshua Watt, Iain S. McGregor, Anastasia S. Suraev, Paul Haber, Kirsten C. Morley · 2026 · Psychopharmacology
  55. Enzyme−Targeted Therapeutics for Neurological Disorders
    Leonardo Massignan, Kanduru Lokesh, Sara Ziadat, David Uehling, Donald Fredric Weaver, Mark A. Reed · 2026 · Journal of Medicinal Chemistry
  56. BindingDB Entry 50009852: Inhibitors of diacylglycerol lipases in neurodegenerative and metabolic disorders.
    BindingDB · 2021 · UC San Diego