Overproduction of Upper-Layer Neurons in the Neocortex Leads to Autism-like Features in Mice

Fang, Wei-Qun; Chen, Wei-Wei; Jiang, Liwen; Liu, Kai; Yung, Wing-Ho; Fu, Amy K.Y.; Ip, Nancy Y.

doi:10.1016/j.celrep.2014.11.003

Overproduction of Upper-Layer Neurons in the Neocortex Leads to Autism-like Features in Mice

The functional integrity of the neocortex depends upon proper numbers of excitatory and inhibitory neurons; however, the consequences of dysregulated neuronal production during the development of the neocortex are unclear. As excess cortical neurons are linked to the neurodevelopmental disorder a…