Wnt Signaling Regulates Multipolar-to-Bipolar Transition of Migrating Neurons in the Cerebral Cortex
Open accessAbstract
The precise timing of pyramidal cell migration from the ventricular germinal zone to the cortical plate is essential for establishing cortical layers, and migration errors can lead to neurodevelopmental disorders underlying psychiatric and neurological diseases. Here, we report that Wnt canonical as well as non-canonical signaling is active in pyramidal precursors during radial migration. We demonstrate using constitutive and conditional genetic strategies that transient downregulation of canonical Wnt/β-catenin signaling during the multipolar stage plays a critical role in polarizing and orienting cells for radial migration. In addition, we show that reduced canonical Wnt signaling is triggered cell autonomously by time-dependent expression of Wnt5A and activation of non-canonical signaling. We identify ephrin-B1 as a canonical Wnt-signaling-regulated target in control of the multipolar-to-bipolar switch. These findings highlight the critical role of Wnt signaling activity in neuronal positioning during cortical development.
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Upregulation of WNT and β-catenin signaling prevents the multipolar to bipolar transition of pyramidal precursors.
“Upregulation of WNT and β-catenin signaling, for example, prevents the multipolar to bipolar transition of pyramidal precursors [103].”
From The ASD Living Biology: from cell proliferation to clinical phenotype (2019) · cites this paper as [103]
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References 54 · Cited by 83
- Authors
- Boitard, M., Bocchi, R., Egervari, K., Petrenko, V., Viale, B., Gremaud, S., Zgraggen, E., Salmon, P., & Kiss, J. Z.
- Affiliations
- University of Geneva (CH)
- Corresponding author
- Kiss, Jozsef Z.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 10
- Issue
- 8
- Pages
- 1349-1361
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2054731037
- Cited by
- 83
- References
- 54
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 2 · 2023: 7 · 2022: 7 · 2021: 6 · 2020: 11 · 2019: 11 · 2018: 7 · 2017: 9 · 2016: 6 · 2015: 3
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Wnt signaling, canonical Wnt/β-catenin pathway, non-canonical Wnt signaling, neuronal migration, pyramidal neurons, radial migration, cortical development, Wnt5a, ephrin-B1, neuronal polarity, cortical plate, neurodevelopmental disorders
- MeSH terms
- Wnt-5a Protein, Animals, Cell Movement, Cerebral Cortex, Embryo, Mammalian, Microscopy, Fluorescence, Neurons, Rats, Wistar, Pyramidal Cells, T-Box Domain Proteins, RNA Interference, RNA, Small Interfering, Ephrin-B1, Wnt Proteins, beta Catenin, Rats, Time-Lapse Imaging, Wnt Signaling Pathway
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