Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis

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Items 101–200 of 214

1. A Novel PAK1–Notch1 Axis Regulates Crypt Homeostasis in Intestinal Inflammation
   Adrian P. Frick, Vineeta Khare, Kristine Jimenez, Kyle W. Dammann, Michaela Lang, Anita Krnjic, Christina Gmainer, Maximilian Baumgartner, Ildikó Mesteri, Christoph Gasché · 2020 · Cellular and Molecular Gastroenterology and Hepatology
2. DOCK4 stimulates MUC2 production through its effect on goblet cell differentiation
   Tingfeng Qin, Jie Yang, Dayin Huang, Zhijun Zhang, Yanling Huang, Hui Chen, Geyang Xu · 2021 · Journal of Cellular Physiology
3. Organoids and Their Use in Modeling Gut Epithelial Cell Lineage Differentiation and Barrier Properties During Intestinal Diseases
   Dianne Pupo Gómez, François Boudreau · 2021 · Frontiers in Cell and Developmental Biology
4. Acquisition of NOTCH dependence is a hallmark of human intestinal stem cell maturation
   Yu-Hwai Tsai, Angeline Wu, Joshua H. Wu, Meghan M. Capeling, Emily M. Holloway, Sha Huang, Michael Czerwinkski, Ian A. Glass, Peter Higgins, Jason R. Spence · 2022 · Stem Cell Reports
5. Deoxynivalenol induces intestinal injury: insights from oxidative stress and intestinal stem cells
   Shaojie Liang, Xiuqi Wang · 2023 · Environmental Science and Pollution Research
6. Phosphorylated Groucho delays differentiation in the follicle stem cell lineage by providing a molecular memory of EGFR signaling in the niche
   Michael J.G. Johnston, Shaked Bar-Cohen, Ze’ev Paroush, Todd G. Nystul · 2016 · Development
7. Signaling and epigenetic mechanisms of intestinal stem cells and progenitors: insight into crypt homeostasis, plasticity, and niches
   Ryan J. Smith, Abilasha Rao‐Bhatia, Tae‐Hee Kim · 2017 · Wiley Interdisciplinary Reviews Developmental Biology
8. Notch Signaling in Cell–Cell Communication Pathways
   Anna Bigas, Lluı́s Espinosa · 2016 · Current Stem Cell Reports
9. The Delayed Effects of Acute Radiation Syndrome
   Catherine E. Booth, Gregory L. Tudor, Barry P. Katz, Thomas J. MacVittie · 2015 · Health Physics
10. Mucosal Mesenchymal Cells: Secondary Barrier and Peripheral Educator for the Gut Immune System
    Yosuke Kurashima, Daiki Yamamoto, Sean A. Nelson, Satoshi Uematsu, Peter B. Ernst, Toshinori Nakayama, Hiroshi Kiyono · 2017 · Frontiers in Immunology
11. Ap4 is rate limiting for intestinal tumor formation by controlling the homeostasis of intestinal stem cells
    Stephanie Jaeckel, Markus Kaller, René Jackstadt, Ursula Götz, Susanna Müller, Sophie Luise Boos, David A. Horst, Peter Jung, Heiko Hermeking · 2018 · Nature Communications
12. The intestinal epithelial response to damage
    Laura Weichselbaum, Ophir D. Klein · 2018 · Science China Life Sciences
13. Genetic architecture underlying changes in carotenoid accumulation during the evolution of the blind Mexican cavefish, Astyanax mexicanus
    Misty R. Riddle, Ariel C. Aspiras, Fleur Damen, John N. Hutchinson, Daniel J.‐F. Chinnapen, Julius A. Tabin, Clifford James Tabin · 2020 · Journal of Experimental Zoology Part B Molecular and Developmental Evolution
14. Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells
    Costanza Borrelli, Tomáš Valenta, Kristina Handler, Karelia Vélez, Alessandra Gurtner, Giulia Moro, Atefeh Lafzi, Laura De Vargas Roditi, George Hausmann, Isabelle Catherine Arnold et al. · 2021 · Nature Communications
15. Depletion of MOB1A/B causes intestinal epithelial degeneration by suppressing Wnt activity and activating BMP/TGF-β signaling
    June Sung Bae, Yoon Jeon, Sun Mi Kim, Ji Yun Jang, Mi Kyung Park, In-Hoo Kim, Deog Su Hwang, Dae‐Sik Lim, Ho Lee · 2018 · Cell Death and Disease
16. Breast milk nutrients driving intestinal epithelial layer maturation via Wnt and Notch signaling: Implications for necrotizing enterocolitis
    Judith C. W. de Jong, Noortje Ijssennagger, Saskia W. C. van Mil · 2021 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
17. Intestinal Stem Cell Niche Insights Gathered from BothIn Vivoand NovelIn VitroModels
    Nikolce Gjorevski, Paloma Ordóñez‐Morán · 2017 · Stem Cells International
18. IRF2 maintains the stemness of colonic stem cells by limiting physiological stress from interferon
    Kana Minamide, Taku Sato, Yusuke Nakanishi, Hiroshi Ohno, Tamotsu Kato, Jumpei Asano, Toshiaki Ohteki · 2020 · Scientific Reports
19. Bisphenol chemicals disturb intestinal homeostasis via Notch/Wnt signaling and induce mucosal barrier dysregulation and inflammation
    Min Peng Zhu, Rongguo Wei, Yuanyuan Li, Jinbo Li, Mengqi Dong, Xuanyue Chen, Lin Lv, Zhanfen Qin · 2022 · The Science of The Total Environment
20. Stem Cells in the Intestine: Possible Roles in Pathogenesis of Irritable Bowel Syndrome
    Sutheera Ratanasirintrawoot, Nipan Israsena · 2016 · Journal of Neurogastroenterology and Motility
21. Recent advances in understanding intestinal stem cell regulation
    Deqing Hu, Han Yan, Xi He, Linheng Li · 2019 · F1000Research
22. Effects of bisphenol A and its alternative bisphenol F on Notch signaling and intestinal development: A novel signaling by which bisphenols disrupt vertebrate development
    Min Peng Zhu, Yuanyuan Li, Yue Niu, Jinbo Li, Zhanfen Qin · 2020 · Environmental Pollution
23. Temporal changes of genes associated with intestinal homeostasis in broiler chickens following a single infection with Eimeria acervulina
    Sara E. Cloft, Katarzyna B. Miska, Mark Christopher Jenkins, Monika Proszkowiec‐Weglarz, S. Kahl, Eric A. Wong · 2023 · Poultry Science
24. Cadmium modulates intestinal Wnt/β-catenin signaling ensuing intestinal barrier disruption and systemic inflammation
    Muskan Verma, Manika Garg, Aiysha Siddiq Khan, Pawan Yadav, Saman Saim Rahman, Asghar Ali, Mohan Kamthan · 2024 · Ecotoxicology and Environmental Safety
25. Somatostatin stimulates colonic MUC2 expression through SSTR5-Notch-Hes1 signaling pathway
    Shuailing Song, Xiao Fan Li, Chong Geng, Yanni Li, Chunhui Wang · 2019 · Biochemical and Biophysical Research Communications
26. MRI-based radiogenomics analysis for predicting genetic alterations in oncogenic signalling pathways in invasive breast carcinoma
    P. Lin, WEI-HUI LIU, X. Li, D. Wan, Hui Qin, Qifeng Li, Gang Chen, Yun He, Hong Yang · 2020 · Clinical Radiology
27. The Act of Controlling Adult Stem Cell Dynamics: Insights from Animal Models
    Meera Krishnan, Sahil Kumar, Luis Johnson Kangale, Éric Ghigo, Prasad Abnave · 2021 · Biomolecules
28. Different in vivo and in vitro transformation of intestinal stem cells in mismatch repair deficiency
    Kerstin Keysselt, Tobias Kreutzmann, Karen Rother, Christiane Kerner, Knuth Krohn, Jens Przybilla, Peter Buske, Henry Loeffler‐Wirth, Markus Loeffler, Joerg Galle et al. · 2016 · Oncogene
29. Glycans that regulate Notch signaling in the intestine
    Mohd Nauman, Pamela Stanley · 2022 · Biochemical Society Transactions
30. Control of Paneth cell function by HuR regulates gut mucosal growth by altering stem cell activity
    Lan Xiao, Bridgette Warner, Caroline G. Mallard, Hee Kyoung Chung, Amol Carl Shetty, Christine A. Brantner, Jaladanki N. Rao, Gregory S. Yochum, Walter A. Koltun, Kathleen B. To et al. · 2023 · Life Science Alliance
31. Murine intestinal stem cells are highly sensitive to modulation of the T3/TRα1-dependent pathway
    Matthias Godart, Carla Frau, Diana Farhat, Maria Virginia Giolito, Catherine Jamard, Clémentine Le Nevé, Jean‐Noël Freund, Luiz O. F. Penalva, Maria Sirakov, Michelina Plateroti · 2021 · Development
32. The Colonic Crypt: Cellular Dynamics and Signaling Pathways in Homeostasis and Cancer
    Anh L. Nguyen, Molly A. Lausten, Bruce M. Boman · 2025 · Cells
33. Modulation of intestinal signal transduction pathways: Implications on gut health and disease
    Muskan Verma, Manika Garg, Pawan Yadav, Aiysha Siddiq Khan, Saman Saim Rahman, Asghar Ali, Mohan Kamthan · 2025 · European Journal of Pharmacology
34. The influence of miR-34a expression on stemness and cytotoxic susceptibility of breast cancer stem cells
    Hongyao Zhang, Ning Li, Jiahui Zhang, Fengjiao Jin, Meihua Shan, Junfang Qin, Yue Wang · 2016 · Cancer Biology & Therapy
35. Intestinal epithelial Notch-1 protects from colorectal mucinous adenocarcinoma
    David Dunkin, Alina Cornelia Iuga, Sanda Mimouna, Carolyn L. Harris, Jean‐Vianney Haure‐Mirande, Dominique Bozec, Garabet Yeretssian, Stéphanie Dahan · 2018 · Oncotarget
36. The eroding chromatin landscape of aging stem cells
    Changyou Shi, Lin Wang, Payel Sen · 2020 · Translational Medicine of Aging
37. Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells
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38. Intestinal Barrier Function and Neurodegenerative Disease
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39. Impact of gut microbiota on host stem cells across the gastrointestinal tract
    Haengdueng Jeong, Yura Lee, Ki Taek Nam · 2025 · Gut Microbes
40. Claudin-7 is essential for the maintenance of colonic stem cell homoeostasis via the modulation of Wnt/Notch signalling
    Kun Wang, Yin Liu, Huimin Li, Xiaoqing Liang, Mengdi Hao, Dajin Yuan, Lei Ding · 2024 · Cell Death and Disease
41. The epithelial C15ORF48/miR-147-NDUFA4 axis is an essential regulator of gut inflammation, energy metabolism, and the microbiome
    Min Xiong, Ze Liu, Bintao Wang, Thomas Sokolich, Natalie Marie Graham, Meirong Chen, Wei-Le Wang, Mark Boldin · 2024 · Proceedings of the National Academy of Sciences
42. Low Concentrations of Tetrabromobisphenol A Disrupt Notch Signaling and Intestinal Development in in Vitro and in Vivo Models
    Min Peng Zhu, Yue Niu, Yuanyuan Li, Mengqi Dong, Jinbo Li, Ran Zeng, Zhanfen Qin · 2020 · Chemical Research in Toxicology
43. Epithelial transport in digestive diseases: mice, monolayers, and mechanisms
    Kim Elaine Barrett · 2020 · American Journal of Physiology-Cell Physiology
44. Liver Regeneration
    Azam Katoonizadeh · 2017 · Elsevier eBooks
45. Homeostasis, injury, and recovery dynamics at multiple scales in a self-organizing mouse intestinal crypt
    Louis Gall, Carrie A. Duckworth, Ferran Jardí, Lieve Lammens, Aimée Parker, Ambra Bianco, Holly H. C. Kimko, David Mark Pritchard, Carmen Pin · 2023 · eLife
46. Comparison of the effect of Sunset yellow on the stomach and small intestine of developmental period of mice
    Erhan Şensoy · 2024 · Heliyon
47. Cooperation of Wnt/β-catenin and Dll1-mediated Notch pathway in Lgr5-positive intestinal stem cells regulates the mucosal injury and repair in DSS-induced colitis mice model
    Weijun Ou, Weimin Xu, Yaosheng Wang, Zhebin Hua, Wenjun Ding, Long Cui, Peng Du · 2023 · Gastroenterology report
48. Diarrhoeal pathogenesis in Salmonella infection may result from an imbalance in intestinal epithelial differentiation through reduced Notch signalling
    Andrew Quach, Rashini R. Jayaratne, Beom Jae Lee, Stella‐Rita Ibeawuchi, Eileen Lim, Soumita Das, Kim Elaine Barrett · 2022 · The Journal of Physiology
49. Src family kinases inhibit differentiation of intestinal epithelial cells through the Hippo effector YAP1
    Sepideh Fallah, Jean‐François Beaulieu · 2021 · Biology Open
50. EGR-1 is an active transcription factor in TGF-β2-mediated small intestinal cell differentiation
    Man Zhang, Yalin Liao, Bo L Lönnerdal · 2016 · The Journal of Nutritional Biochemistry
51. The tyrosine phosphatase Shp‐2 confers resistance to colonic inflammation by driving goblet cell function and crypt regeneration
    J Gagné Sansfaçon, Ariane Langlois, Marie‐Josée Langlois, Geneviève Coulombe, Sarah Tremblay, Vanessa Vaillancourt‐Lavigueur, Cheng‐Kui Qu, Alfredo Menéndez, Nathalie Rivard · 2018 · The Journal of Pathology
52. Frizzled 7 modulates goblet and Paneth cell fate, and maintains homeostasis in mouse intestine
    Nai-Xin Gu, Yuru Guo, Sey‐En Lin, Yen-Hsin Wang, I‐Hsuan Lin, Yi‐Fan Chen, Yun Yen · 2023 · Development
53. Tcf4 regulates secretory cell fate decisions in the small intestine and colon tumors: insights from transcriptomic, histological, and microbiome analyses
    Lucie Janečková, Monika Šťastná, Dušan Hrčkulák, Linda Berková, Jan Kubovčiak, Jakub Onhajzer, Vı́tězslav Křı́ž, Stela Dostalikova, Tereza Mullerova, Kateřina Večerková et al. · 2025 · Stem Cell Research & Therapy
54. Signaling Network Centered on mTORC1 Dominates Mammalian Intestinal Stem Cell Ageing
    Shaojie Liang, Jiayi Zhou, Xiuqi Wang · 2020 · Stem Cell Reviews and Reports
55. Environmentally relevant concentrations of benzophenones exposure disrupt intestinal homeostasis, impair the intestinal barrier, and induce inflammation in mice
    Yu‐Jia Lin, Hong-Mei Li, Yan-Rong Gao, Ping-Fan Wu, Bin Cheng, Chen-Long Yu, Yu-Xin Sheng, Haiming Xu · 2024 · Environmental Pollution
56. Shifting the Focus of Signaling Abnormalities in Colon Cancer
    Markus A. Brown, Thomas Ried · 2022 · Cancers
57. Sox17 Promotes Oligodendrocyte Regeneration by Dual Modulation of Hedgehog and Wnt Signaling
    Xiaotian Ming, Jeffrey L. Dupree, Vittorio Gallo, Li‐Jin Chew · 2020 · iScience
58. Fermented black soldier fly larvae as a sustainable replacement for marine fish in Asian swamp eel diets
    Yang Xiang, Shanxing Gao, Yiming Luo, Gaojian Tang, Xiuwei Zou, Kai Xie, Wenjie Niu, Xinyi Li, Junan Xiang, Ling Zhang et al. · 2025 · Veterinary World
59. Lactobacillus derived from breast milk facilitates intestinal development in IUGR rats
    Linzheng Lyu, Xiaohong Zhou, Meng Zhang, Li Liu, Tongjie Liu, Haiyue Niu, Yifan Wu, Cong Liang, Xue Han, Lanwei Zhang · 2022 · Journal of Applied Microbiology
60. Epithelial-mesenchymal transition and nuclear β-catenin induced by conditional intestinal disruption ofCdh1withApcis E-cadherin EC1 domain dependent
    Julia Matheson, Claudia Bühnemann, Emma J. Carter, David Barnes, Hans-Jürgen Hoppe, Jennifer Hughes, Stephen Paul Cobbold, James Harper, Hans M. Morreau, Mirvat Surakhy et al. · 2016 · Oncotarget
61. Notch Signaling Orchestrates Helminth-Induced Type 2 Inflammation
    Lauren M. Webb, Elia D. Tait Wojno · 2019 · Trends in Immunology
62. Secretomics Alterations and Astrocyte Dysfunction in Human iPSC of Leukoencephalopathy with Vanishing White Matter
    Jiong Deng, Jie Zhang, Kai Gao, Wei Yan, Ling Zhou, Yuwu Jiang, Jingmin Wang, Ye Wu · 2022 · Neurochemical Research
63. Intestinal organoid technology and applications in probiotics
    Han Tan, Xiaoyong Chen, Chen Wang, Jiajia Song, Jiahui Xu, Yuhong Zhang, Huayi Suo · 2023 · Critical Reviews in Food Science and Nutrition
64. The intestinal stem cell as a target: A review
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65. Glycoprotein (GP)96 Is Essential for Maintaining Intestinal Epithelial Architecture by Supporting Its Self-Renewal Capacity
    Janine Häfliger, Marlene Schwarzfischer, Kirstin Atrott, Claudia Stanzel, Yasser Morsy, Marcin Wawrzyniak, Silvia Lang, Tomáš Valenta, Konrad Basler, Gerhard Rogler et al. · 2022 · Cellular and Molecular Gastroenterology and Hepatology
66. Defining key concepts of intestinal and epithelial cancer biology through the use of mouse models
    Toby James Phesse, Victoria Marsh Durban, Owen James Sansom · 2017 · Carcinogenesis
67. Subclinical Necrotic Enteritis Impacts Developmental Notch and Wnt Signaling and Intestinal Morphology in the Small Intestine of Broiler Chickens
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68. From mucus secretion to immune surveillance: the evolving roles of goblet cells in intestinal homeostasis and inflammation
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69. EOGT enables residual Notch signaling in mouse intestinal cells lacking POFUT1
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70. Recent Advances and Mechanism of Nanomaterials Promoting Tumor Metastasis
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71. Notch inhibition counteracts Paneth cell death in absence of caspase-8
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72. Wnt/β-Catenin Pathway Activation Confers Fumonisin B1 Tolerance in Chicken Intestinal Organoid Monolayers by Enhancing Intestinal Stem Cell Function
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73. Intestinal stem cell niche: An upcoming area of immense importance in gastrointestinal disorders
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74. Phosphatidylinositol 3-Kinase Signaling Enhances Intestinal Crypt Epithelial Cell Recovery after Radiation
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75. New insights into methionine’s role in maintaining intestinal stem cell regeneration via autophagy regulation
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76. Translation initiation factor eIF2Bε promotes Wnt-mediated clonogenicity and global translation in intestinal epithelial cells
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77. Integrin α7β1 represses intestinal absorptive cell differentiation
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78. Effect of monochromatic light on self-renewal and differentiation of intestinal stem cells in broilers
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79. Decoding ‘Wntch’: the intertwined Wnt and Notch pathways in development and disease
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80. A fusion protein composed of the DSL domain of Dll1 and RGD motif protects cryptic stem cells in irradiation injury
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81. Exercise alters transcriptional profiles of senescence and gut barrier integrity in intestinal crypts of aging mice
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82. Distinct molecular responses of human intestinal organoids to proton and photon radiation
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83. Multitasking Paneth Cells in the Intestinal Stem Cell Niche
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84. Survival and cellular heterogeneity of epithelium in cultured mouse and rat precision-cut intestinal slices
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85. Sparfloxacin ameliorates DSS-induced ulcerative colitis by suppressing cellular senescence, JAK/NF-κB signaling pathway and modulation of the gut microbiota-metabolite axis
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86. Notch Pathway Regulation of Intestinal Cell Fate
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87. Extracellular stiffness regulates site-specific lung development
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88. α‐Linolenic Acid Alleviated Intestinal Inflammation and Dyshomeostasis Induced by Obesity in Mice
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89. Mapping of colorectal carcinoma diseases with activation of Wnt/beta-catenin signalling pathway using hierarchical clustering approach
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90. IPSC-derived intestinal organoids and current 3D intestinal scaffolds
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99. PIEZO-dependent mechano-sensing of the niche is essential for intestinal stem cell fate decision and maintenance
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100. Colitogenic Environment Suppresses Notch/Mechanistic Target of Rapamycin–Mediated Epithelial Proliferation to Promote Goblet Cell Differentiation in the Colon
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