Intestinal monocyte-derived macrophages control commensal-specific Th17 responses
Open accessAbstract
Generation of different CD4 T cell responses to commensal and pathogenic bacteria is crucial for maintaining a healthy gut environment, but the associated cellular mechanisms are poorly understood. Dendritic cells (DCs) and macrophages (Mfs) integrate microbial signals and direct adaptive immunity. Although the role of DCs in initiating T cell responses is well appreciated, how Mfs contribute to the generation of CD4 T cell responses to intestinal microbes is unclear. Th17 cells are critical for mucosal immune protection and at steady state are induced by commensal bacteria, such as segmented filamentous bacteria (SFB). Here, we examined the roles of mucosal DCs and Mfs in Th17 induction by SFB in vivo. We show that Mfs, and not conventional CD103(+) DCs, are essential for the generation of SFB-specific Th17 responses. Thus, Mfs drive mucosal T cell responses to certain commensal bacteria.
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Presentation of SFB-derived antigens by intestinal antigen-presenting cells is sufficient for TH17 cell development.
“presentation of SFB-derived antigens by intestinal APCs was shown to be sufficient for TH17 cell development (Goto et al., 2014; Panea et al., 2015).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Panea et al., 2015
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References 48 · Cited by 152
- Authors
- Panea, C., Farkas, A. M., Goto, Y., Abdollahi-Roodsaz, S., Lee, C., Koscsó, B., Gowda, K., Hohl, T. M., Bogunovic, M., & Ivanov, I. I.
- Affiliations
- Columbia University (US)
- Pennsylvania State University (US)
- Memorial Sloan Kettering Cancer Center (US)
- Columbia University Irving Medical Center (US)
- Corresponding author
- Ivanov, Ivaylo I.
- ORCID
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 12
- Issue
- 8
- Pages
- 1314-1324
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC4567384
- OpenAlex
- W1948104206
- Cited by
- 152
- References
- 48
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 5 · 2023: 11 · 2022: 15 · 2021: 19 · 2020: 18 · 2019: 12 · 2018: 19 · 2017: 17 · 2016: 10 · 2015: 4
- FWCI
- 8.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Radboud Repository (Radboud University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Funders
- Memorial Sloan-Kettering Cancer Center
- National Institutes of Health
- Japan Society for the Promotion of Science (15H06159)
- National Institute of Allergy and Infectious Diseases (R01AI093808, R37AI093808)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK098378)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- intestinal macrophages, monocyte-derived macrophages, Th17 cells, segmented filamentous bacteria, commensal bacteria, mucosal immunity, dendritic cells, CD103+ dendritic cells, CD4+ T cell responses, gut microbiota, mucosal tolerance
- MeSH terms
- CX3C Chemokine Receptor 1, Animals, Cells, Cultured, Dendritic Cells, Intestinal Mucosa, Macrophages, Antigens, CD, Receptors, Chemokine, Integrin alpha Chains, Mice, Th17 Cells, Microbiota
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