Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer

Kugel, Sita; Feldman, Jessica L.; Klein, Mark A.; Silberman, Dafne M.; Sebastián, Carlos; Mermel, Craig; Dobersch, Stephanie; Clark, Abbe R.; Getz, Gad; Denu, John M.; Mostoslavsky, Raul

doi:10.1016/j.celrep.2015.09.022

Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer

Chromatin factors have emerged as the most frequently affected family of proteins in cancer. We have previously identified the histone deacetylase SIRT6 as a key tumor suppressor, yet whether point mutations are selected for in cancer remains unclear. In this manuscript, we characterized naturall…