NCOA4 deficiency impairs systemic iron homeostasis

Bellelli, Roberto, Federico, Giorgia, Matte’, Alessandro, Colecchia, David, Iolascon, Achille, Chiariello, Mario, Santoro, Massimo, De Franceschi, Lucia +1 more·2016·Cell Reports
DOI 10.1016/j.celrep.2015.12.065

Cited by (248)

Items 201–248 of 248

  1. Novel Insights and Future Perspective in Iron Metabolism and Anemia
    Immacolata Andolfo, Roberta Russo · 2022 · Metabolites
  2. Blocking (iron) traffic in the gut
    Karin E. Finberg · 2022 · Blood
  3. Myeloid NCOA4 sequesters KEAP1 to reduce ferroptosis for protection against salmonellosis in mice.
    Xiang Xue, Mariella Arcos, Zhaoli Liu, Luke Villareal, Paloma Kai Velez, Sharina Palencia Desai, Achraf Noureddine, David R Martin, C. Jeffrey Brinker, Donna D. Zhang · 2024 · Research Square
  4. Obesity rewires CD8+ T cell iron metabolism in adipose tissue to fuel metabolic inflammation
    Jinfen Dai, Zixuan Zeng, Lishuan Wang, Wei Yuan, Karina Cunha e Rocha, Junho Park, Garam An, Ke Wang, Jisoo Song, Qian Xiang et al. · 2025 · Metabolism
  5. The genetic and biochemical basis of human leading strand synthesis
    Alessandro Agnarelli, Lauryn Buckley-Benbow, Meryem Ozgencil, Melanie Lad, Khamal Kwesi Ampah, Alex T. Kalinka, Ondrej Beláň, Sarah Maslen, Mark J. Skehel, David Walter et al. · 2025 · Nature Communications
  6. Hepatic Iron Overload in Heavy Drinkers: Molecular Mechanisms and Relation to Hemolysis and Enhanced Red Blood Cell Turnover
    Sebastian Mueller, Johannes H. Mueller, Siyuan Li, Chaowen Zheng, Cheng Chen · 2023 · Springer eBooks
  7. A novel brick on the wall of non-alcoholic fatty liver disease (NAFLD): Nuclear receptor coactivator 4 (NCOA4)
    Mete Tuğcan Üçdal, Ayşe Buruş, Başak Çeltikçi, Hatice Yasemin Balaban · 2023 · Medical Hypotheses
  8. BBB damage in aging causes brain iron deposits via astrocyte-neuron crosstalk and Hepc/Fpn1 pathway
    Mariarosa Mezzanotte, Giorgia Ammirata, Marina Boido, Serena Stanga, Antonella Roetto · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  9. Autologous Platelet-Rich Gel Accelerates Diabetic Wound Healing Through Inhibition of Ferritinophagy
    Daoai Wu, Ping Zhu, Zhaoming Shi, Chen Li, Chenchen Wu, Weihua Sun, Jianmin Ran · 2024 · The International Journal of Lower Extremity Wounds
  10. H2S inhibits high glucose-induced osteoblast injury by inhibiting ferroptosis in diabetic osteoporosis in vitro
    Qingping Shi, Feihong Chen, Wen Wu · 2025 · Brazilian Journal of Medical and Biological Research
  11. The role of ribosomal protein RPL35A in heme regulation and hematopoiesis in the blood clam Anadara granosa
    Mengshi Zhang, Yushan Liao, Zhihua Lin, Xin He, Yongbo Bao · 2025 · Aquaculture
  12. Piezo-mediated inhibition of ferroptosis alleviates acute liver injury
    Shiyuan Liang, Xingyue He, Cong Liu, Jiangkun Yan, Jiangtao Xue, Wei Liu, Liyuan Chen, Kailiang Ren, Zhou Li, Yan Liu et al. · 2026 · Cell Biomaterials
  13. Ferritin: Master Regulator of Iron Metabolism in Health and Disease
    Onyekachi Ewa Ibe, Nnaemeka Okorie, Dennis Akongfe Abunimye, Ebere Anastasia Ezaka, Sylvester N. Ibekailo, Chukwu Chibuike Victor, Jonathan Ogbonnaya Enyi, Cyprian Emeka Oguji, Valerie Esame Njar, Akhabue Itua Igene · 2025 · Physiology
  14. Iron Metabolism in the Colorectal Tumor Microenvironment: From Preneoplastic Lesions to Cancer Progression
    Anamaria-Vlăduța Tomoiagă, S. Suciu, Cezara-Andreea Gerdanovics, Alexandru Gerdanovics, Mircea Vasile Milaciu, Mirela-Georgiana Perné, Teodora Alexescu, Lorena Ciumărnean, Angela Cozma, Vasile Negrean et al. · 2026 · International Journal of Molecular Sciences
  15. Rotavirus infection induces ferroptosis through NCOA4-mediated ferritinophagy in IPEC-J2 cells
    Ye Zhao, Xia Dong, Qingkuo Lan, Luqian She, Yongsheng Hu, Lei Chen, Mailin Gan, Lili Niu, Yan Wang, Xiaofeng Zhou et al. · 2026 · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology
  16. Intra-arterial delivery of FePt nanoparticles induces ferroptosis and immune infiltration to enhance radiotherapy
    Yaowei Yeh, Yuhsuan Huang, Yanshen Shan, Shangyin Wu, Hsiuyun Wang, Paosheng Hou, Yifu Chang, Wuchou Su, Helen H.W. Chen, Chiajui Yen et al. · 2026 · Materials Today Bio
  17. Ferroptosis
    Daiqing Liao · 2021 · Elsevier eBooks
  18. The role of nuclear receptor co-activator 4 in erythropoiesis (Reply to Nai et al.)
    Naiara Santana-Codina, Sebastian Gableske, Mark D. Fleming, J. Wade Harper, Alec C. Kimmelman, Joseph Douglas Mancias · 2019 · Haematologica
  19. Intestinal ferritinophagy is regulated by HIF-2α and is essential for systemic iron homeostasis
    Nupur Kanti Das, Amanda D. Sankar, Andrew J. Schwartz, Sumeet A. Solanki, Xiaoya Ma, Sanjana Parimi, Naiara Santana-Codina, Joseph Douglas Mancias, Yatrik Madhukar Shah · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  20. High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleen
    Wan-ping Yang, Mei-qi Li, Jie Min Ding, Jiayan Li, Gang Wu, Bao Liu, Yuqi Gao, Guohua Wang, Qianqian Luo · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  21. High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleen
    Wan-ping Yang, Mei-qi Li, Jie Min Ding, Jiayan Li, Gang Wu, Bao Liu, Yuqi Gao, Guohua Wang, Qianqian Luo · 2023 · eLife
  22. The autophagy receptor Ncoa4 controls PPARγ activity and thermogenesis in brown adipose tissue
    Leslie A. Rowland, Kaltinaitis B. Santos, Adı́lson Guilherme, Sean Munroe, Lawrence M. Lifshitz, Sarah M. C. Nicoloro, Hui Wang, Matthew F. Yee, Michael Czech · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  23. Ferritinophagy Loss Drives Mitochondrial Iron Import and Colorectal Tumorigenesis
    Xiang Xue, Hyeoncheol Kim, Luke Villareal, Naiara Santana-Codina, Christian V. Cabanlong, Lavanya Goodla, Eric R. Prossnitz, David R Martin, Joseph Douglas Mancias · 2025 · Research Square
  24. Data demonstrating the role of peroxiredoxin 2 as important anti-oxidant system in lung homeostasis
    Enrica Federti, Alessandro Mattè, Alessandra Ghigo, Immacolata Andolfo, James Cimino, Angela Siciliano, Christophe Lebœuf, Anne Janin, Francesco Manna, Soo Young Choi et al. · 2017 · Data in Brief
  25. Iron and Heme Coordinate Erythropoiesis through HRI-Mediated Regulation of Protein Translation and Gene Expression
    Shuping Zhang, Alejandra Macias-Garcia, Jacob C. Ulirsch, Jason G. Velazquez, Vincent L. Butty, Stuart S. Levine, Vijay G. Sankaran, Jane-Jane Chen · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  26. Liposome doxorubicin attenuates cardiotoxicity by reducing ferritinophagy
    Yating Yu, Haiyue Niu, Mengying Zhang, Mengyuan Liu, Yue Zhang, Jinyue Yang, Yumei Liu, Limin Xing, Zonghong Shao, Rong Fu et al. · 2023 · Research Square
  27. High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleen
    Wan-ping Yang, Mei-qi Li, Jie Min Ding, Jiayan Li, Gang Wu, Bao Liu, Yuqi Gao, Guohua Wang, Qianqian Luo · 2023 · eLife
  28. Research advances of ferritinophagy in renal diseases
    Qi Wang · 2023 · International Journal of Frontiers in Medicine
  29. High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleen
    Wan-ping Yang, Mei-qi Li, Jie Min Ding, Jiayan Li, Gang Wu, Bao Liu, Yuqi Gao, Guohua Wang, Qianqian Luo · 2024 · eLife
  30. Myeloid NCOA4 sequesters KEAP1 to reduce ferroptosis for protection against salmonellosis in mice.
    Xiang Xue, Mariella Arcos, Zhaoli Liu, Luke Villareal, Paloma Kai Velez, Sharina Palencia Desai, Achraf Noureddine, David R Martin, C. Jeffrey Brinker, Donna D. Zhang · 2024 · Research Square
  31. WITHDRAWN: Experimental study on improvement of lung injury in septic rats by inhibiting RIOK3-ferritin autophagy axis with Ginkgo biloba extract
    Xueling Zhang, Di Huang, Minghao Liang, Zhishen Ruan, Yifei Xu, Zhanjun Qiu, Xianhai Chen · 2024 · Pharmacological Research - Modern Chinese Medicine · Retracted
  32. The role of antioxidant supplementation in neuronal disorders
    Asmaa Mohammed ShamsEldeen, Hania Ibrahim Ammar, Fahaid H. Al-Hashem, Zienab A. Alrefaie, Mohamed Hasan Aly, Mira Hanna · 2025 · Elsevier eBooks
  33. Additional file 1 of AMPK activation eliminates senescent cells in diabetic wound by inducing NCOA4 mediated ferritinophagy
    Liu, Mengqian, Xuerong Wei, Zheng, Zijun, Erlian Xie, Qiuyi Yu, Yanbin Gao, Jun Ma, Yang, Lei · 2024 · Figshare
  34. Additional file 1 of Inhibition of IRP2-dependent reprogramming of iron metabolism suppresses tumor growth in colorectal cancer
    Jieon Hwang, Areum Park, Chinwoo Kim, Kim, Chang Gon, Jaesung Kwak, Byungil Kim, Shin, Hyunjin, Minhee Ku, Yang, Jaemoon, Baek, Ayoung et al. · 2024 · Figshare
  35. Ferroptosis-mediated cell death in erythroblasts treated with the ATR inhibitor camonsertib (RP-3500)
    Maayan Levy, Gino B. Ferraro, Yongshuai Han, Giorgia Federico, Lilian Varricchio, Vijay Nandi, Xiuli An, Ronald Hoffman, Francesca Carlomagno, Adrian J. Fretland et al. · 2026 · Blood Red Cells & Iron
  36. Autophagy deficiency in red pulp macrophages impairs their function and resistance to iron stress
    Raquel Sal-Carro, Alice C Lavanant, Marina Blanc, Gabriel Rojas-Jiménez, Blandine Maître, Christopher George Mueller, Benjamin Voisin, Emmanuel L. Gautier, Frédéric Gros, Vincent Flacher · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  37. La sérotonine intestinale : un acteur essentiel de la régulation de l'homéostasie du fer
    Marion Falabrègue · 2020
  38. Régulation du métabolisme du fer et nouvelles stratégies thérapeutiques
    Audrey Belot · 2020 · theses.fr (ABES)
  39. Apport dans le métabolisme du fer du modèle murin macrophage autophagie déficient & relations fer - inflammation
    Meriem Taleb · 2021 · theses.fr (ABES)
  40. The miR-212-3p/transferrin axis promotes bone regeneration by modulating iron homeostasis through Schwann cell Exosome-BMSCs communication
    Yukun Jia, Ningdao Li, Dagang Tang, Wendan Pu, Zhiqiang Feng, Yingtao Duan, Yafei Zhu, Juan Wang, Xiaoji Luo, Jun Zhang (48506) · 2026 · Bioactive Materials
  41. Chronic intermittent hypobaric hypoxia ameliorates iron metabolism disorder through ferritinophagy in collagen-induced arthritis mice
    XueRui Fu, Fang Cui, RuoTong Wang, Shuang Liu, YunLu Zhao, Aijing Liu, Bingyan Guo, Chen Jia, Manna Zhang, Di Hao et al. · 2026 · Journal of Trace Elements in Medicine and Biology
  42. Quercetin-Induced Ferroptosis Attenuates Pancreatic Ductal Adenocarcinoma via Facilitating NCOA4-Dependent Ferritinophagy
    Chang Li, Liya Zhou, Xunzhe Yin · 2026 · The American Journal of Chinese Medicine
  43. Fueling Death: The Metabolic Control of Ferroptosis
    Giovanna Carrà, Alfonso Scalera, Isaia Barbieri, Alessio Menga, Paolo Ettore Porporato · 2026 · Advances in experimental medicine and biology
  44. Post-translational modification-regulating biomaterials for regeneration
    Adilijiang Abudousu, Yun-Kai Tang, Bai-Kun Liu, Lei Xiang, Zhen Wang, Yi-Han Li, Ding Zhao, Wen-Guo Cui · 2026 · Bioactive Materials
  45. Nicotinamide Mononucleotide Combined Glucose Counteracts Iron Overload–Induced Mitochondrial Dysfunction in Mice Under Hypobaric Hypoxia
    Fancheng Tan, Xiaoyun Huang, Xiaoya Mao, 王广义, Xingyao Wang, Feitai Tang, Xing Chen, Ridong Mao, Xiaoyu Gong, Lin Chen et al. · 2026 · Molecular & Cellular Proteomics
  46. Biophysical and molecular determinants of NCOA4-mediated ferritinophagy at the ferroptosis–inflammation interface: Compartmental iron transport, lipid oxidation, and causal constraints
    Rabab S. Hamad, Marwa S. Zaghloul, Ahmed Shata, Doaa N. Abdallah, Alshaimaa Hamdi Abd Elmaksoud, Sherihan I. Gouda, Nesreen Elsayed Morsy, Shereen Mohamed Hamed, Sameh Saber · 2026 · Progress in Biophysics and Molecular Biology
  47. Context-Dependent Roles of NCOA4-Mediated Ferritinophagy in Liver Diseases: From Ferroptosis to Fibrosis Reversal and Therapeutic Targeting
    Tianxiao Duan, Bin Cen, Xihui HUANG, Binbin Jin · 2026 · Livers
  48. Iron Homeostasis and Liver Diseases
    Peng Yang, Z X Shi, Qin Huang, Zhihong Tu, Yue Sun, Lin Wang, Yonglong Wei · 2026 · Journal of Cellular and Molecular Medicine