MTAP deletions in cancer create vulnerability to targeting of the MAT2A/PRMT5/RIOK1 axis
Marjon, Katya, Cameron, Michael J., Quang, Phong, Clasquin, Michelle F., Mandley, Everton, Kunii, Kaiko, McVay, Michael, Choe, Sung +9 more·2016·Cell Reports
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- BindingDB Entry 50020273: Discovery of novel methionine adenosyltransferase 2A (MAT2A) allosteric inhibitors by structure-based virtual screening.BindingDB · 2024 · UC San Diego
- BindingDB Entry 50020674: Design and Structural Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High In Vivo Potency and Oral Bioavailability.BindingDB · 2024 · UC San Diego
- BindingDB Entry 50021285: Development of a Series of Pyrrolopyridone MAT2A Inhibitors.BindingDB · 2025 · UC San Diego
- BindingDB Entry 50016955: Overview of Methionine Adenosyltransferase 2A (MAT2A) as an Anticancer Target: Structure, Function, and Inhibitors.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50023341: From DNA-Encoded Library Screening to AM-9747: An MTA-Cooperative PRMT5 Inhibitor with Potent Oral In Vivo Efficacy.BindingDB · 2026 · UC San Diego
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