CD40 stimulation obviates innate sensors and drives T cell immunity in cancer
Byrne, Katelyn T., Vonderheide, Robert H.·2016·Cell Reports
Cited by (283)
Items 201–283 of 283
- Combined sublethal irradiation and agonist anti-CD40 enhance donor T cell accumulation and control of autochthonous murine pancreatic tumorsLindsay K. Ward-Kavanagh, Kathleen M. Kokolus, Timothy K. Cooper, Aron E. Lukacher, Todd D. Schell · 2018 · Cancer Immunology Immunotherapy
- Myeloid-targeting immunotherapies overcome inhibitory barriers in immune-evasive neuroblastomaMarie J. Menard, Hiroyuki Yoda, Nicole M. Nasholm, Megumi J. Barata, Linyu Wang, Erin F. Simonds, Edbert D Lu, Shannon Wong‐Michalak, Lauren McHenry, Alvin Farrel et al. · 2025 · The Journal of Experimental Medicine
- Inhibition of osteosarcoma lung metastases by β-glucan and CD40 agonist is mediated by activation of macrophages and NK cellsPradeep Shrestha, Rejeena Shrestha, Eugenie S. Kleinerman · 2025 · Journal for ImmunoTherapy of Cancer
- Novel therapeutic strategies in pancreatic cancer: moving beyond cytotoxic chemotherapyBarbara Geerinckx, Laure-Anne Marie Nicole Teuwen, Tiffany Foo, Timon Vandamme, Annabel Smith, Marc Peeters, Timothy Jay Price · 2023 · Expert Review of Anticancer Therapy
- Current Clinical Landscape of Immunotherapeutic Approaches in Pancreatic Cancer TreatmentPooya Farhangnia, Shamim Mollazadeh Ghomi, Shabnam Mollazadehghomi, Ali‐Akbar Delbandi · 2023 · Interdisciplinary cancer research
- Pre-Clinical Investigations of the Pharmacodynamics of Immunogenic Smart Radiotherapy Biomaterials (iSRB)Michèle Moreau, Shahinur Acter, Lindokuhle M. Ngema, Noella Bih, Gnagna Sy, Lensa S. Keno, Kwok Fan Chow, Erno Sajo, Oscar Nebangwa, Jacques Walker et al. · 2023 · Pharmaceutics
- Exogenous signaling repairs defective T cell signaling inside the tumor microenvironment for better immunityCasey Moore, Joonbeom Bae, Longchao Liu, Huiyu Li, Yang‐Xin Fu, Jian Qiao · 2022 · JCI Insight
- Immunotherapeutic Approaches in CancerMahsa Keshavarz‐Fathi, Nima Rezaei · 2018 · Elsevier eBooks
- Pancreatic cancer – What's next?Roberto Salvia, Fabio Casciani, Elisabetta Sereni, Claudio Bassi · 2019 · La Presse Médicale
- Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal AdenocarcinomaCeire A. Hay, Rina Sor, Ahron J. Flowers, Cynthia J. Clendenin, Katelyn T. Byrne · 2019 · Journal of Visualized Experiments
- Leveraging cDC1 biology and function for enhanced immunotherapyRoss W. Ward, Uddipan Kar, Sreekumar Balan, Nina Bhardwaj · 2026 · The Journal of Experimental Medicine
- Agonistic anti-CD40 converts Tregs into Type 1 effectors within the tumor micro-environmentVivien Ileana Maltez, Charu Arora, Rina Sor, Qiaoshi Lian, Robert H. Vonderheide, Ronald N. Germain, Katelyn T. Byrne · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Intratumoral expression of IL-12 and CD40 ligand (CD154) from plasmids generates antitumor responses that eliminate tumoral T regsGregory W. Ho, Alicia Santos, Jennifer L. Fields, Pamela C. Rosato, Mary Jo Turk, Nicole F. Steinmetz, Steven Fiering · 2025 · Scientific Reports
- Agonistic anti-CD40 antibody treatment converts resident regulatory T cells into activated type 1 effectors within the tumor microenvironmentVivien Ileana Maltez, Charu Arora, Kyle P. Gribbin, Breanna P Caruso, Margaret E. Haerr, Rina Sor, Qiaoshi Lian, Katie E. Blise, Shamilene Sivagnanam, Rosalie C. Sears et al. · 2026 · Immunity
- CD4+ T Cells Mediate MHC-Deficient Tumor Rejection and Endothelial Cell ReprogrammingSamuel I. Kim, Margaret E. Haerr, Maryam Al-Ghezi, Canping Chen, Yi Zhang, Jackie L. Phipps, Charu Arora, Kyle P. Gribbin, G.T. Kim, Nune Markosyan et al. · 2025 · Cancer Immunology Research
- Interrogating the CD27:CD70 axis in αCD40-dependent control of pancreatic adenocarcinomaAwndre Gamache, Claire A Conarroe, Sara J. Adair, Todd W. Bauer, Frederic R. Padilla, Timothy N. J. Bullock · 2023 · Frontiers in Cell and Developmental Biology
- Pre-clinical evaluation of immunoPET imaging using agonist CD40 monoclonal antibody in pancreatic tumor-bearing miceSadaf Aghevlian, Bo Wu, Marina Nura Raie, Spencer K. Tumbale, Aris J. Kare, Jai Woong Seo, Katherine W. Ferrara · 2021 · Nuclear Medicine and Biology
- Interleukin 6 Drives Durable T Cell-Mediated Immunity to Pancreatic CancerPaige C. Arneson‐Wissink, Alexandra Q. Bartlett, Heike Mendez, Xinxia Zhu, Peter R. Levasseur, Parham Diba, Namratha Turuvekere Vittala Murthy, Jessica Dickie, Matthew McWhorter, Antony Jozić et al. · 2026 · Cellular and Molecular Gastroenterology and Hepatology
- Emerging pharmaceutical therapies for targeting cholangiocarcinoma microenvironment and chemokine pathwaysArmand N Yazdani, Michaela C. Pletsch, Abraham Chorbajian, David Zitser, Vikrant Rai · 2024 · Biocell
- Impact of CD40 (rs1883832) and CD40L (rs1126535) gene variants on laryngeal cancer susceptibility and their association with serum biomarker levels of sCD40 and sCD40LAlper Gümüş, Dilara Sönmez, Şeyda Demirkol, Mehmet Tolgahan Hakan, Ayşegül Verim, Yusufhan Süoğlu, İlhan Yaylım, Arzu Ergen · 2024 · PLoS ONE
- Immunotherapy for Pancreatic CancerYoshiaki Sunami, Simon Rieder, Patrick Michl, Jorg H. Kleeff · 2023 · Springer eBooks
- Immuno-Oncology in Pancreatic CancerNigel Balfour Jamieson, Colin William Steele · 2021 · Springer eBooks
- Multiplex spatial systems analysis of local nanodose drug responses predicts effective treatment combinations of immunotherapies and targeted agents in mammary carcinomaZuzana Tatárová, Dylan C. Blumberg, James E. Korkola, Laura M. Heiser, John L. Muschler, Pepper J. Schedin, Sebastian W. Ahn, Gordon Brent Mills, Lisa M. Coussens, Oliver H. Jonas et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- CD4 memory T cells orchestrate therapy-responsive immune niches in colorectal cancer liver metastasesMaud Mayoux, Gioana Litscher, Fabius Wiesmann, Marijne Vermeer, Pau Jorba Adolff, Elena Guido Vinzoni, Nicolás Gonzalo Núñez, Colin Sparano, Viola Katharina Vetter, Ekaterina Friebel et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Immunotherapeutic strategies in hepatopancreatobiliary cancersMassimiliano Salati, Alessandro Rizzo, Angela Dalia Ricci, Angelica Petrillo, Alessandro Parisi · 2024 · Elsevier eBooks
- Immunotherapy for Pancreatic CancerYoshiaki Sunami, Simon Rieder, Patrick Michl, Jorg H. Kleeff · 2025 · Springer eBooks
- Localized Delivery of Anti‐CD40/PD‐1 Immunotherapy via a Polymeric Implant is Efficacious, Remodels the Tumor Immune Microenvironment and Improves Safety in a PDAC Mouse ModelElahe Minaei, Samantha J. Wade, Chelsea Penney, Marie Ranson, Morteza Aghmesheh, Ronald Sluyter, Kara L. Vine · 2025 · Advanced Healthcare Materials
- CD154 Restricts Helminth‐Induced Macrophage Polarisation and Proliferation While Promoting Tissue ResidenceMariana Suárez‐Martins, James E Parkinson, Lili Zhang, Brian H. K. Chan, Georgia Baldwin, Rebecca J. Dodd, Conor M. Finlay, Pedro Henrique Papotto, Judith E. Allen, Álvaro Díaz · 2025 · Parasite Immunology
- Cross‐Cancer Perspectives on CD40 Agonist Therapy: Modulating the Tumor Immune Microenvironment华旭东, Junyan Hua, Yanzhong Wang · 2026 · Journal of Biochemical and Molecular Toxicology
- Docetaxel‐Induced Immune Activation Shows Antitumor Synergy With the Tumor‐Targeted CD40 Agonist KK2269Yuta Tezuka, Kyoko Kawasaki, Yoshiki Sumitomo, Masato Saito, Akari Yao, Munetoshi Ando · 2026 · Cancer Science
- Intratumoral Sotigalimab with Pembrolizumab Induces Rapid Activation of Antigen-Presenting Cells and Drives Antitumor Responses in Non-injected Tumors in Metastatic Melanoma: A Phase I/II StudySalah-Eddine Bentebibel, Daniel James McGrail, Veena Kochat, Emre Arslan, Reham Abdel‐Wahab, Barbara Pazdrak, Ravi Murthy, Nourel Hoda Tahon, S H Cho, Dzifa Y. Duose et al. · 2026 · Cancer Discovery
- Macrophage-directed therapeutic strategies in cancerShweta Joshi, Judith A. Varner · 2026 · Trends in cancer
- Cellular Indoctrination: How the Tumor Microenvironment Reeducates Macrophages Towards Nefarious EndsAmy A. Powers, Seth H. Eisenberg, Katherine Elizabeth Jones, Laura P. Stabile, Michael T. Lotze, Rajeev Dhupar, Adam C. Soloff · 2021 · Elsevier eBooks
- An open protocol for modeling T Cell Clonotype repertoires using TCRβ CDR3 sequencesBurcu Gurun, Wesley R. Horton, Dhaarini Murugan, Biqing Zhu, Patrick Leyshock, Sushil Kumar, Katelyn T. Byrne, Robert H. Vonderheide, Adam A. Margolin, Motomi Mori et al. · 2023 · BMC Genomics
- Reliable prognostic definition and immunotherapy response prediction in bladder cancer, based on a novel aging-associated 5-gene signature modelWei Meng, Ningning Li, Bo Chen, Huajun Zhang, Limin Ma, Yangbo Guan · 2024 · Translational Andrology and Urology
- The engineered agonistic anti-CD40 antibody potentiates the antitumor effects of β-glucan by resetting TAMsWanpeng Cheng, Ziyi Huang, Yongzhe Hao, Hui Hua, Bo Zhang, Xiangyang Li, Fengqing Fu, Jing Yang, Kuiyang Zheng, Xueguang Zhang et al. · 2024 · Immunology Letters
- Macrophage IL-4 polarization is restricted by soluble CD40 agonists and antigen-induced CD154 but not by constitutive CD154 expressed by CD4+ T cellsMariana Suárez‐Martins, Ignacio González-Alayón, Cecilia Casaravilla, Louis Boon, Pedro Henrique Papotto, Conor M. Finlay, Stephen John Jenkins, Judith E. Allen, Álvaro Díaz · 2025 · Journal of Leukocyte Biology
- Immunotherapy in Pancreatic CancerBassel F. El‐Rayes, Mehmet Akce · 2020 · Digestive Disease Interventions
- Activating Immune Recognition in Pancreatic Ductal Adenocarcinoma Using Autophagy Inhibition, MEK blockade and CD40 AgonismHonglin Jiang, Tristan Courau, Leonard C. Lupin-Jimenez, Joseph Borison, Alexa J. Ritchie, Aaron T. Mayer, Matthew F. Krummel, Eric Andrew Collisson · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Mapping intratumoral myeloid-T cell interactomes at single-cell resolution reveals targets for overcoming checkpoint inhibitor resistanceKate Bridges, Gabriela A. Pizzurro, Alev Baysoy, Janani P. Baskaran, Ziyan Zoe Xu, Varsha Mathew, Victoria Tripple, Michael LaPorte, Koonam Park, William Damsky et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Congrès de l’association américaine de recherche contre le cancer — AACR 2016Cécile Vicier, Éléonore De Guillebon, A. Kieffer, Anthony Turpin, Clément Dumont, Audrey Bellesœur, Daniele Grazziotin Soares, Jean‐Pierre Lotz · 2016 · ONCOLOGIE
- Anti-CD40/Anti-CD40LDavid S. Kotlyar, Anthony Joseph Leonardi · 2016 · Springer eBooks
- Targeting the Immune System in Pancreatic CancerDerya Kabacaoğlu, Dietrich Alexander Ruess, Hana Algül · 2020 · Molecular and translational medicine
- Perancangan Aplikasi Sistem Pakar Untuk Diagnosis Penyakit Ginjal Dengan Kombinasi Metode Certainty Factor Dan Metode Forward ChainingRumondang Silalahi · 2011
- Congrès de l’association américaine de recherche contre le cancer — AACR 2018Sandra Assoun, Marc‐Antoine Benderra, Arthur Géraud, A. Bayle, Alice Boilève, Daniele Grazziotin Soares, Jean‐Pierre Lotz · 2018 · ONCOLOGIE
- Anti-CD40/Anti-CD40LDavid S. Kotlyar, Anthony Joseph Leonardi · 2017 · Springer eBooks
- Tumor-Specific CD4 T Cells Instruct Monocyte Differentiation in Pancreatic Ductal AdenocarcinomaMichael T. Patterson, Adam L. Burrack, Yingzheng Xu, Zoe C. Schmiechen, Patricia R. Schrank, Ainsley E. Kennedy, Maria M. Firulyova, Ebony A. Miller, Eduardo Cruz-Hinojoza, Konstantin Zaitsev et al. · 2022 · SSRN Electronic Journal
- Low TFPI2 expression is associated with poor prognosis and defective immune cell infiltration in breast cancer diseaseCheng Zhu, Ying Dai, Yanyan Zhang, Hua Wang, Xiaolei Hu · 2022 · Research Square
- The Prospects of Immunotherapy in Pancreatic CancerHaoqiang Ying, Wantong Yao · 2022 · Springer eBooks
- Data from Efficacy of CD40 Agonists Is Mediated by Distinct cDC Subsets and Subverted by Suppressive MacrophagesAleksandar Murgaski, Máté Kiss, Helena Van Damme, Daliya Kancheva, Isaure Vanmeerbeek, Jiri Keirsse, Éva Hadadi, Jan Brughmans, Sana M. Arnouk, Ahmed E.I. Hamouda et al. · 2023
- Data from Efficacy of CD40 Agonists Is Mediated by Distinct cDC Subsets and Subverted by Suppressive MacrophagesAleksandar Murgaski, Máté Kiss, Helena Van Damme, Daliya Kancheva, Isaure Vanmeerbeek, Jiri Keirsse, Éva Hadadi, Jan Brughmans, Sana M. Arnouk, Ahmed E.I. Hamouda et al. · 2023
- Data from CD40 Agonist Targeted to Fibroblast Activation Protein α Synergizes with Radiotherapy in Murine HPV-Positive Head and Neck TumorsSara Labiano, Vincent Roh, Céline Godfroid, Agnès Hiou‐Feige, Jackeline F. Romero, Eva Sum, Moritz Rapp, Gaël Boivin, Tania Wyss, Christian Simon et al. · 2023
- Data from CD40 Agonist Targeted to Fibroblast Activation Protein α Synergizes with Radiotherapy in Murine HPV-Positive Head and Neck TumorsSara Labiano, Vincent Roh, Céline Godfroid, Agnès Hiou‐Feige, Jackeline F. Romero, Eva Sum, Moritz Rapp, Gaël Boivin, Tania Wyss, Christian Simon et al. · 2023
- Data from Site-Dependent Immune Escape Due to Impaired Dendritic Cell Cross-PrimingMark S. Diamond, Jeffrey Lin, Robert H. Vonderheide · 2023
- Data from A Multispecific Anti-CD40 DARPin Construct Induces Tumor-Selective CD40 Activation and Tumor RegressionNicolò Rigamonti, Niina Veitonmäki, Clara Domke, Sophie Barsin, Sarah Jetzer, Omar Abdelmotaleb, Ralph Bessey, Tamara Lekishvili, Francesca Malvezzi, Mariam A. Gachechiladze et al. · 2023
- Systemic Oncosphere: Host Innate Immune SystemPhei Er Saw, Erwei Song · 2023 · Springer eBooks
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- Immune-Checkpoint Inhibitors: A New Line of Attack in Triple-Negative Breast CancerOuissam Al Jarroudi, Khalid El Bairi, Giuseppe Curigliano, Saïd Afqir · 2023 · Cancer treatment and research
- Additional file 4 of An open protocol for modeling T Cell Clonotype repertoires using TCRβ CDR3 sequencesBurcu Gurun, Wesley R. Horton, Dhaarini Murugan, Biqing Zhu, Patrick Leyshock, Sushil Kumar, Katelyn T. Byrne, Robert H. Vonderheide, Adam A. Margolin, Motomi Mori et al. · 2023 · Figshare
- Safety, Efficacy, and Biomarker Results of a Phase 1b/2 Study Combining the CD40 Agonist Mitazalimab with mFOLFIRINOX in Previously Untreated Metastatic Pancreatic Ductal Adenocarcinoma (mPDAC); Results of the OPTIMIZE-1 TrialJean‐Luc Van Laethem, Ivan Borbath, Hans Prenen, Karen Paula Geboes, Aurélien Lambert, Emmanuel Mitry, Philippe Alexandre Cassier, Jean‐Frédéric Blanc, Lorenzo Pilla, Jaime Feliu Batlle et al. · 2024 · SSRN Electronic Journal
- Overcoming immunotherapeutic drug resistance in pancreatic and colon cancersMario Tavakoli, Hasan Raza, Dirin Ukwade, Dexter Nwachukwu, Salimah Mohamed, Saeed Ali · 2025 · Elsevier eBooks
- Advancing cancer immunotherapy through novel CD40-focused antibody engineering platformsBarnabas Nyesiga · 2025
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- ATOR-4066, a Bispecific Antibody Targeting CD40 and CEACAM5, Induces Strong Myeloid and T Cell–Dependent Tumor Immunity and Synergizes with PD-1 BlockadeHampus Andersson, Ida Elin Maria Uddback, Tova Hermodsson, Mona Celander, Amulya Krishna Shetty, Lill Ljung, Anneli Nilsson, Anette Sundstedt, Laura von Schantz, Laura A. Varas et al. · 2025 · Cancer Immunology Research
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- Additional file 1 of C4b-binding protein α-chain enhances antitumor immunity by facilitating the accumulation of tumor-infiltrating lymphocytes in the tumor microenvironment in pancreatic cancerSasaki, Kosuke, Takano, Shigetsugu, Satoshi Tomizawa, Miyahara, Yoji, Furukawa, Katsunori, Takayashiki, Tsukasa, Kuboki, Satoshi, Takada, Mamoru, Masayuki Ohtsuka · 2021 · Figshare
- Additional file 3 of An open protocol for modeling T Cell Clonotype repertoires using TCRβ CDR3 sequencesBurcu Gurun, Wesley R. Horton, Dhaarini Murugan, Zhu, Biqing, Patrick Leyshock, Sushil Kumar, Katelyn T. Byrne, Robert H. Vonderheide, Adam A. Margolin, Motomi Mori et al. · 2023 · Figshare
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- Additional file 2 of C4b-binding protein α-chain enhances antitumor immunity by facilitating the accumulation of tumor-infiltrating lymphocytes in the tumor microenvironment in pancreatic cancerSasaki, Kosuke, Takano, Shigetsugu, Satoshi Tomizawa, Miyahara, Yoji, Furukawa, Katsunori, Takayashiki, Tsukasa, Kuboki, Satoshi, Takada, Mamoru, Masayuki Ohtsuka · 2021 · Figshare
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- Enhanced antitumor efficacy through combined chimeric antigen receptor T cell therapy and CD40 stimulation in syngeneic solid tumor modelsGiulia Golinelli, Ting–Jia Fan, Khatuna Gabunia, Wesley V. Wilson, Charles‐Antoine Assenmacher, He N Xu, Diego Gonzalves, Sofia Castelli, Jordan Reff, David Mai et al. · 2026 · Cytotherapy
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