CD40 stimulation obviates innate sensors and drives T cell immunity in cancer

Byrne, Katelyn T., Vonderheide, Robert H.·2016·Cell Reports

Cited by (283)

Items 201–283 of 283

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  7. Exogenous signaling repairs defective T cell signaling inside the tumor microenvironment for better immunity
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  8. Immunotherapeutic Approaches in Cancer
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  9. Pancreatic cancer – What's next?
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  10. Ultrasound-Guided Orthotopic Implantation of Murine Pancreatic Ductal Adenocarcinoma
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  11. Leveraging cDC1 biology and function for enhanced immunotherapy
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  12. Agonistic anti-CD40 converts Tregs into Type 1 effectors within the tumor micro-environment
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  13. Intratumoral expression of IL-12 and CD40 ligand (CD154) from plasmids generates antitumor responses that eliminate tumoral T regs
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  14. Agonistic anti-CD40 antibody treatment converts resident regulatory T cells into activated type 1 effectors within the tumor microenvironment
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  16. Interrogating the CD27:CD70 axis in αCD40-dependent control of pancreatic adenocarcinoma
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  17. Pre-clinical evaluation of immunoPET imaging using agonist CD40 monoclonal antibody in pancreatic tumor-bearing mice
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  18. Interleukin 6 Drives Durable T Cell-Mediated Immunity to Pancreatic Cancer
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  20. Impact of CD40 (rs1883832) and CD40L (rs1126535) gene variants on laryngeal cancer susceptibility and their association with serum biomarker levels of sCD40 and sCD40L
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  24. CD4 memory T cells orchestrate therapy-responsive immune niches in colorectal cancer liver metastases
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  27. Localized Delivery of Anti‐CD40/PD‐1 Immunotherapy via a Polymeric Implant is Efficacious, Remodels the Tumor Immune Microenvironment and Improves Safety in a PDAC Mouse Model
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  28. CD154 Restricts Helminth‐Induced Macrophage Polarisation and Proliferation While Promoting Tissue Residence
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  29. Cross‐Cancer Perspectives on CD40 Agonist Therapy: Modulating the Tumor Immune Microenvironment
    华旭东, Junyan Hua, Yanzhong Wang · 2026 · Journal of Biochemical and Molecular Toxicology
  30. Docetaxel‐Induced Immune Activation Shows Antitumor Synergy With the Tumor‐Targeted CD40 Agonist KK2269
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  33. Cellular Indoctrination: How the Tumor Microenvironment Reeducates Macrophages Towards Nefarious Ends
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  36. The engineered agonistic anti-CD40 antibody potentiates the antitumor effects of β-glucan by resetting TAMs
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  37. Macrophage IL-4 polarization is restricted by soluble CD40 agonists and antigen-induced CD154 but not by constitutive CD154 expressed by CD4+ T cells
    Mariana Suárez‐Martins, Ignacio González-Alayón, Cecilia Casaravilla, Louis Boon, Pedro Henrique Papotto, Conor M. Finlay, Stephen John Jenkins, Judith E. Allen, Álvaro Díaz · 2025 · Journal of Leukocyte Biology
  38. Immunotherapy in Pancreatic Cancer
    Bassel F. El‐Rayes, Mehmet Akce · 2020 · Digestive Disease Interventions
  39. Activating Immune Recognition in Pancreatic Ductal Adenocarcinoma Using Autophagy Inhibition, MEK blockade and CD40 Agonism
    Honglin Jiang, Tristan Courau, Leonard C. Lupin-Jimenez, Joseph Borison, Alexa J. Ritchie, Aaron T. Mayer, Matthew F. Krummel, Eric Andrew Collisson · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  40. Mapping intratumoral myeloid-T cell interactomes at single-cell resolution reveals targets for overcoming checkpoint inhibitor resistance
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  41. Congrès de l’association américaine de recherche contre le cancer — AACR 2016
    Cécile Vicier, Éléonore De Guillebon, A. Kieffer, Anthony Turpin, Clément Dumont, Audrey Bellesœur, Daniele Grazziotin Soares, Jean‐Pierre Lotz · 2016 · ONCOLOGIE
  42. Anti-CD40/Anti-CD40L
    David S. Kotlyar, Anthony Joseph Leonardi · 2016 · Springer eBooks
  43. Targeting the Immune System in Pancreatic Cancer
    Derya Kabacaoğlu, Dietrich Alexander Ruess, Hana Algül · 2020 · Molecular and translational medicine
  44. Perancangan Aplikasi Sistem Pakar Untuk Diagnosis Penyakit Ginjal Dengan Kombinasi Metode Certainty Factor Dan Metode Forward Chaining
    Rumondang Silalahi · 2011
  45. Congrès de l’association américaine de recherche contre le cancer — AACR 2018
    Sandra Assoun, Marc‐Antoine Benderra, Arthur Géraud, A. Bayle, Alice Boilève, Daniele Grazziotin Soares, Jean‐Pierre Lotz · 2018 · ONCOLOGIE
  46. Anti-CD40/Anti-CD40L
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  47. Tumor-Specific CD4 T Cells Instruct Monocyte Differentiation in Pancreatic Ductal Adenocarcinoma
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  48. Low TFPI2 expression is associated with poor prognosis and defective immune cell infiltration in breast cancer disease
    Cheng Zhu, Ying Dai, Yanyan Zhang, Hua Wang, Xiaolei Hu · 2022 · Research Square
  49. The Prospects of Immunotherapy in Pancreatic Cancer
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  50. Data from Efficacy of CD40 Agonists Is Mediated by Distinct cDC Subsets and Subverted by Suppressive Macrophages
    Aleksandar Murgaski, Máté Kiss, Helena Van Damme, Daliya Kancheva, Isaure Vanmeerbeek, Jiri Keirsse, Éva Hadadi, Jan Brughmans, Sana M. Arnouk, Ahmed E.I. Hamouda et al. · 2023
  51. Data from Efficacy of CD40 Agonists Is Mediated by Distinct cDC Subsets and Subverted by Suppressive Macrophages
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  52. Data from CD40 Agonist Targeted to Fibroblast Activation Protein α Synergizes with Radiotherapy in Murine HPV-Positive Head and Neck Tumors
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  54. Data from Site-Dependent Immune Escape Due to Impaired Dendritic Cell Cross-Priming
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  55. Data from A Multispecific Anti-CD40 DARPin Construct Induces Tumor-Selective CD40 Activation and Tumor Regression
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  59. Additional file 4 of An open protocol for modeling T Cell Clonotype repertoires using TCRβ CDR3 sequences
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  60. Safety, Efficacy, and Biomarker Results of a Phase 1b/2 Study Combining the CD40 Agonist Mitazalimab with mFOLFIRINOX in Previously Untreated Metastatic Pancreatic Ductal Adenocarcinoma (mPDAC); Results of the OPTIMIZE-1 Trial
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  67. Additional file 1 of C4b-binding protein α-chain enhances antitumor immunity by facilitating the accumulation of tumor-infiltrating lymphocytes in the tumor microenvironment in pancreatic cancer
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  68. Additional file 3 of An open protocol for modeling T Cell Clonotype repertoires using TCRβ CDR3 sequences
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  70. Additional file 2 of C4b-binding protein α-chain enhances antitumor immunity by facilitating the accumulation of tumor-infiltrating lymphocytes in the tumor microenvironment in pancreatic cancer
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