Broadly Neutralizing Activity of Zika Virus-Immune Sera Identifies a Single Viral Serotype
Open accessAbstract
Recent epidemics of Zika virus (ZIKV) have been associated with congenital malformation during pregnancy and Guillain-Barré syndrome. There are two ZIKV lineages (African and Asian) that share >95% amino acid identity. Little is known regarding the ability of neutralizing antibodies elicited against one lineage to protect against the other. We investigated the breadth of the neutralizing antibody response following ZIKV infection by measuring the sensitivity of six ZIKV strains to neutralization by ZIKV-confirmed convalescent human serum or plasma samples. Contemporary Asian and early African ZIKV strains were similarly sensitive to neutralization regardless of the cellular source of virus. Furthermore, mouse immune serum generated after infection with African or Asian ZIKV strains was capable of neutralizing homologous and heterologous ZIKV strains equivalently. Because our study only defines a single ZIKV serotype, vaccine candidates eliciting robust neutralizing antibody responses should inhibit infection of both ZIKV lineages, including strains circulating in the Americas.
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All Zika infections are caused by a single serotype.
“Fortunately, all Zika infections are caused by a single serotype, suggesting that vaccinating against an antigen from any strain could protect against all Zika strains152.”
From mRNA vaccines for infectious diseases: principles, delivery and clinical translation (2021) · cites this paper as [152]
Vaccinating against an antigen from any Zika strain could protect against all Zika strains.
“Fortunately, all Zika infections are caused by a single serotype, suggesting that vaccinating against an antigen from any strain could protect against all Zika strains152.”
From mRNA vaccines for infectious diseases: principles, delivery and clinical translation (2021) · cites this paper as [152]
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References 41 · Cited by 206
- Authors
- Dowd, K. A., DeMaso, C. R., Pelc, R. S., Speer, S. D., Smith, A. R. Y., Goo, L., Platt, D. J., Mascola, J. R., Graham, B. S., Mulligan, M. J., Diamond, M. S., Ledgerwood, J. E., & Pierson, T. C.
- Affiliations
- National Institutes of Health (US)
- Washington University in St. Louis (US)
- Emory University (US)
- Corresponding author
- Pierson, Theodore C.
- ORCID
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 16
- Issue
- 6
- Pages
- 1485-1491
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC5004740
- OpenAlex
- W2482332858
- Cited by
- 206
- References
- 41
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 8 · 2023: 11 · 2022: 10 · 2021: 15 · 2020: 25 · 2019: 34 · 2018: 35 · 2017: 48 · 2016: 13
- FWCI
- 42.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Commons@Becker (Washington University School of Medicine) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Sanofi
- Emory University
- Georgia Research Alliance
- Moderna
- National Institutes of Health
- School of Medicine, Emory University
- National Institute of Allergy and Infectious Diseases (ZIAAI001022, R01AI073755)
- NHLBI Division of Intramural Research
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- Zika virus, neutralizing antibodies, viral serotypes, heterologous protection, vaccine design, congenital malformations, Guillain-Barré syndrome
- MeSH terms
- Zika Virus Infection, Zika Virus, Antibodies, Viral, Humans, Immune Sera, Antibodies, Neutralizing, Serogroup
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