Brain State Dependence of Hippocampal Subthreshold Activity in Awake Mice
Open accessAbstract
Monitoring the membrane potential of individual neurons has uncovered how single-cell properties contribute to network processing across different brain states in neocortex. In contrast, the subthreshold modulation of hippocampal neurons by brain state has not been systematically characterized. To address this, we combined whole-cell recordings from dentate granule cells and CA1 pyramidal neurons with multisite extracellular recordings and behavioral measurements in awake mice. We show that the average membrane potential, amplitude of subthreshold fluctuations, and distance to spike threshold are all modulated by brain state. Furthermore, even within individual states, rapid variations in arousal are reflected in membrane potential fluctuations. These factors produce depolarizing ramps in the membrane potential of hippocampal neurons that precede ripples and mirror transitions to a network regime conducive for ripple generation. These results suggest that there are coordinated shifts in the subthreshold dynamics of individual neurons that underlie the transitions between distinct modes of hippocampal processing.
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Changes in arousal modulate the membrane potential of hippocampal pyramidal neurons and hippocampal dynamics, and are gated by spatial location.
“Our findings are in line with previous work, which showed that changes in arousal modulate the membrane potential of hippocampal pyramidal neurons75 and hippocampal dynamics75–78, and are gated by spatial location77.”
From Place and behavioral modulation of hippocampal neurons during immobility (2026) · cites this paper as [75]
Theoretical models propose that remapping occurs because cells respond to global contextual cues in order to decorrelate related experiences with distinct contextual relevance.
“Theoretical models of this phenomenon propose that remapping occurs because these cells are responding to global contextual cues (like arousal or attention) in order to decorrelate related experiences with distinct contextual relevance.27,28”
From Remapping in a recurrent neural network model of navigation and context inference (2023) · cites this paper as [28]
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References 62 · Cited by 40
- Authors
- Hulse, B. K., Lubenov, E. V., & Siapas, A. G.
- Affiliations
- California Institute of Technology (US)
- Corresponding author
- Siapas, Athanassios G.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 18
- Issue
- 1
- Pages
- 136-147
- ISSN
- 2211-1247 (ISSN-L)
- PMC
- PMC5217705
- OpenAlex
- W2569046604
- Cited by
- 40
- References
- 62
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2023: 13 · 2022: 5 · 2021: 3 · 2020: 2 · 2019: 3 · 2018: 6 · 2017: 2
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion, cc-by-nc-nd)
- Funders
- Mathers Foundation
- Moore Foundation
- NIH (1DP1OD008255/5DP1MH099907)
- NSF (IOS-1146871)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampus, brain states, membrane potential, dentate gyrus granule cells, CA1 pyramidal neurons, ripples, arousal, spike threshold, network oscillations, awake mice
- MeSH terms
- Animals, Hippocampus, Male, Membrane Potentials, Mice, Inbred C57BL, Neurons, Pupil, Wakefulness
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