Identification of interleukin-1 by functional screening as a key mediator of cellular expansion and disease progression in acute myeloid leukemia

Carey, Alyssa, Edwards, David K., Eide, Christopher A., Newell, Laura, Traer, Elie, Medeiros, Bruno C., Pollyea, Daniel A., Deininger, Michael W. +6 more·2017·Cell Reports

DOI 10.1016/j.celrep.2017.03.018

Cited by (271)

Items 201–271 of 271

Lymphocytes from B-acute lymphoblastic leukemia patients present differential regulation of the adenosinergic axis depending on risk stratification
Vitória Brum da Silva Nunes, Camila Kehl Dias, Juliete Nathali Scholl, Alexia Nedel Sant’Ana, Amanda de Fraga Dias, Mariela Granero Farias, Ana Paula Alegretti, Monalisa Sosnoski, Liane Esteves Daudt, Mariana Bohns Michalowski et al. · 2022 · Discover Oncology
Reading Between the Lines: Complete Blood Count-Derived Parameters as Prognostic Factors in Patients With Newly Diagnosed Acute Myeloid Leukemia
Paulina Stefaniuk, Justyna Muzyka-Kasietczuk, Dorota Koczkodaj, Marek Hus, Monika Podhorecka · 2025 · Clinical Medicine Insights Oncology
A proteogenomic gene signature defines prognostic subgroups highlighting PI3K/AKT/mTOR signaling pathway as a therapeutic vulnerability in myeloid malignancies
Fan He, Shuyang Lin, Bei Gao, Varun Ramesh, Alexander Byungsuk Kim, Tim Kong, Daniel A.C. Fisher, Christopher T. Letson, Molly Brakhane, Mary C. Fulbright et al. · 2025 · Cell Communication and Signaling
Targeting the NLRP3 inflammasome signalling in acute myeloid leukemia: Mechanisms, therapeutics, and future directions
Sally H. Fayad, Alaa Mohamed Salah, Ayad A. Jaffa, Nadine Darwiche · 2025 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Scaffolding-dependent CASP1 constrains excessive cell-intrinsic inflammatory signaling in leukemia
Emma E. Uible, Issac Choi, Courtnee A. Clough, Aishlin Hassan, Annabelle J. Anandappa, Julianna Fisher, Bibek Karki, Kathleen M. Hueneman, Kwangmin Choi, Eric J. Vick et al. · 2026 · Cell chemical biology
Antibiotic and glucocorticoid-induced recapitulated hematological remission in acute myeloid leukemia: A case report and review of literature
Xiao-Yun Sun, Xiao-Dong Yang, Xiao-Qiu Yang, Bo Ju, Nuan-Nuan Xiu, Jia Xu, Xi-Chen Zhao · 2022 · World Journal of Clinical Cases
High TCTA expression is an adverse prognostic biomarker in acute myeloid leukemia
Yunli Shao, Tong Qin · 2024 · Cancer Biomarkers
A common ground: an in silico assessment of the sources of intrinsic ex vivo resistance to venetoclax in acute myeloid leukemia
BGS Macedo, Manuela Albuquerque de Melo, Diego A. Pereira‐Martins, João Agostinho Machado‐Neto, Fabı́ola Traina · 2025 · Hematology Transfusion and Cell Therapy
A specific bone marrow cytokine pattern in de novo acute myeloid leukemia
Noémie Ravalet, Hélène Guermouche, Pierre Hirsch, Frédéric Picou, Vincent Flament, Caroline Deswarte, Amélie Foucault, Jenny Beaud, Emmanuelle Rault, Emeline Saindoy et al. · 2025 · Clinical Immunology
Acute Myeloid Leukemia Genomics: Impact on Care and Remaining Challenges
Ann‐Kathrin Eisfeld, Elaine R. Mardis · 2024 · Clinical Chemistry
Minimal role of interleukin 6 and toll-like receptor 2 and 4 in murine models of immune-mediated bone marrow failure
Sabrina Solorzano, Jisoo Kim, Jichun Chen, Xingmin Feng, Neal S. Young · 2021 · PLoS ONE
RNAi screening of the tyrosine kinome in primary patient samples of acute myeloid leukemia
David K. Edwards, Fatma Eryildiz, Jeffrey W Tyner · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
ASC specks: a biomarker for myelodysplastic syndromes?
Dominik Georg Friedrich Wolf, Eicke Latz · 2018 · The Lancet Haematology
Leukemia and Heart Disease
Philipp J. Rauch, Benjamin L. Ebert · 2022 · JACC CardioOncology
The transcriptional and epigenetic reprogramming associated with chronic IL1β-mediated expansion and myeloid priming in TET2 deficient stem and progenitor cells
John McClatchy, Ruslan Strogantsev, E. Wolfe, Hong Lin, M. Mohammadhosseini, Brett A. Davis, Christopher O. Eden, D. Goldman, WH Fleming, P Conley et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
Effect of vitamin D status on a disintegrin-like and metalloprotease with thrombospondin type 1 motif 13 (ADAMTS13) and interleukin 6 in patients with acute myeloid leukaemia
Dina Ashraf Abdelhady, Mervat Azab, Ahmed A. Alnagar, Nora M. Said · 2025 · European journal of medical research
Acute myeloid leukemia after CAR T-cell therapy: role of pre-existing clonal hematopoiesis and inflammation in leukemogenesis
Paul Chauvet, Cynthia Saade, Julie Demaret, David Beauvais, Micha Srour, Léonardo Magro, Valérie Coiteux, Nicolas Gazeau, Nicolas Branche, Catherine Roche‐Lestienne et al. · 2025 · Bone Marrow Transplantation
Elucidating the risk factors and oncogene drivers of acute myeloid leukemia
Daniel Ruben Akiola Sanya, Djamila Onésime · 2025 · Human Cell
The Immune Microenvironment in Acute Myeloid Leukemia: Mechanisms of Immune Evasion and Emerging Therapeutic Strategies
Vinod Kumar Singh, Prithpal Singh Matreja, Sudhir Singh, Seema Awasthi · 2025 · Journal of Blood and Cancer
Epigenetic reactivation of the tumor suppressor ZBTB7A by KDM4 inhibition in human acute myeloid leukemia
Alexander Arnuk, Cuijuan Han, Abimbola Eunice. Lawal, Bofei Wang, Sadik Karma, Zhiping Zhang, Mhd Yousuf Yassouf, Sakthi Harini Rajendran, Harshpreet Chandok, Madeline L. Eller et al. · 2026 · Science Translational Medicine
Immune interplay between sepsis and haematological malignancies
Stéphanie Pons, Morgane Grosset, Emmanuelle Touze, Lara Zafrani · 2026 · Intensive Care Medicine Experimental
Inflammatory signatures in the spectrum of myeloid diseases
Alice Ibbotson, Simon Crouch, Jacqueline Ferrari, Thomas Young, Ann Wendy Morgan, Anna Gallì, Sara Pozzi, Martina Sarchi, Virginia Camilotto, Martina Boldini et al. · 2026 · HemaSphere
Acute myeloid leukemia with adult atopic dermatitis as first manifestation
Weiwei Ma, Lorna Martin Kasyanju Carrero, Xufeng Yin, Hou-Fang Liu, Bing-Rong Zhou · 2019 · Medicine
Trained and ready - the case for an inflammatory memory for hematopoietic stem and progenitor cells in the AML niche
Ding-Wen Chen, Eric K. Wafula, Peter Kurre · 2024 · Oncotarget
Combinatorial drug-microenvironment interaction mapping reveals cell-extrinsic drug resistance mechanisms and clinically relevant patient subgroups in CLL
Peter‐Martin Bruch, Holly A. R. Giles, Carolin Kolb, Sophie A. Herbst, Tina Becirovic, Tobias Roider, Junyan Lu, Sebastian Scheinost, Lena Wagner, Jennifer Hüellein et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
Single-cell characterisation of the hematopoietic bone marrow interactome in health and disease
Sarah Ennis, Alessandra Jordano Conforte, Eimear O’Reilly, Tatiana Cichocka, Sukhraj Pal Singh Dhami, Pamela Nicholson, Philippe Krebs, Pilib Ó Broin, Éva Szegezdi · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
Upregulation of Genetic Markers of Poor Prognosis following Chemotherapy in Acute Myeloid Leukemia Cells
A. Taylor, Michael K. Strasser, Marlee K. Ng, Irit Rubin, A. Kaipainen, A. Pisco, Sui Huang · 2026 · bioRxiv
MDS Stem Cell Biology
Matthew T. Villaume, Paul Brent Ferrell, Michael Robert Savona · 2020 · Springer eBooks
Absence of the Shb gene in mixed-lineage leukemia MLL-AF9 cells increases latency in mice despite higher proliferation rates in vitro
Maria Jamalpour, Eric Bergquist, Michael Welsh · 2020 · Experimental Cell Research
Inhibition of Interleukin-1 Receptor-Associated Kinase-1 is a Therapeutic Strategy for Acute Myeloid Leukemia Subtypes
Mona Mohammadhosseini · 2018
Interleukin-6 level is a powerful predictor of risk for acute myeloid leukemia (AML) among Iraqi patients
Esraa S. Al-Fatlawey, Ikhlass Ali Hussein Al-Hilaly, Ali M. Omara · 2022 · International Journal of Health Sciences
SGOL1-AS1 Enhances Cell Survival in Acute Myeloid Leukemia by Maintaining Pro-Inflammatory Signaling
Georges Lacaud, Ewan Selkirk, Rahima Patel, Anna Hoyle, Michael Lie‐A‐Ling, Duncan L. Smith, Joe Swift · 2022 · SSRN Electronic Journal
The role of IL-1 in tumor growth and angiogenesis
Kinjal P. Bhadresha, Pradeep K. Shukla, Pratibha Singh · 2023 · Elsevier eBooks
Reading between the lines – complete blood count parameters as prognostic factors in patients with newly diagnosed acute myeloid leukemia
Paulina Stefaniuk, Justyna Muzyka-Kasietczuk, Dorota Koczkodaj, Marek Hus, Monika Podhorecka · 2023 · Research Square
The difference of double-positive T cells and double-negative-T cells in myeloid neoplasms before and after chemotherapy, and after COVID-19 infection
Xinyu Guo, Xiaotong Ren, Yuanjia Duan, Zonghong Shao, Rong Fu, Huaquan Wang, Zhaoyun Liu, Hui Liu, Lijuan Li · 2024 · Research Square
Additional file 2 of Identification and validation of signal recognition particle 14 as a prognostic biomarker predicting overall survival in patients with acute myeloid leukemia
Lingling Shi, Rui Huang, Yongrong Lai · 2021 · Figshare
Identification and Validation of Oxidative Stress-Related Biomarkers for Bronchopulmonary Dysplasia
Zhenzhuang Zou, Yunrong Li, Jiaying Liu, Bo Huang · 2024 · Molecular Biotechnology
THE EFFECT OF HIGH INTENSITY INTERVAL TRAINING (HIIT) AND L-CYSTEINE CONSUMPTION ON THE LEVEL OF COX2 AND IL-1B IN THE HEART TISSUE OF RATS WITH TYPE 2 DIABETES
orhan Khodayi Zavyah, Lotfali Bolboli, Marefat Siahkuhian, Behrouz Baghaiee · 2024 · Studies in Medical Sciences
Untangling Ariadne’s Thread Within the Bone Marrow Maze: A Close-Up View of Stem/Progenitor Cells’ Interactome and Secretome
Dimitrios Agas, Maria Giovanna Sabbieti · 2025 · Advances in experimental medicine and biology
The NLRP3 inflammasome and its role in acute myeloid leukemia onset and development
BGS Macedo, Manuela Albuquerque de Melo, Diego A. Pereira‐Martins, João Agostinho Machado‐Neto, Fabı́ola Traina · 2025 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Clonal memory of cell division in humans diverges between healthy haematopoiesis and acute myeloid leukaemia
Alessandro Donada, Gurvan Hermange, Tiziana Tocci, Adil Midoun, Giulio Prevedello, Louisa Hadj Abed, Délia Dupré, Wenjie Sun, Idan Milo, Sabrina Tenreira Bento et al. · 2026 · Nature Communications
Study of PI3/AKT signaling pathway role in Acute myeloid Leukemia through assessment of long non-coding RNAs, GAS6-AS1 and TINCR expression
Nourane Tawfik, Nermeen Ahmed Mohamed Eldabah · 2025 · The Egyptian Journal of Haematology
Significance of the tendency for relative bradycardia during induction therapy for acute myeloid leukemia
Ryutaro Tominaga, Shin‐ichiro Fujiwara, Seina Honda, Daizo Yokoyama, Atsuto Noguchi, Shuka Furuki, Shunsuke Koyama, Rui Murahashi, Hirotomo Nakashima, Kazuki Hyodo et al. · 2025 · International Journal of Hematology
Comparison the impact of IFN-β alone or in combination with vitamin D on critical pathways involved in AML progression
Farzad Nasri, Hassan Jalaeikhoo, Maryam Dadmanesh, Nafiseh Behranvand, Reza Falak, Negin Hosseini Rouzbahani, Yalda Babaei, Khodayar Ghorban · 2025 · PLoS ONE
Additional file 2 of CD45dimCD34+CD38−CD133+ cells have the potential as leukemic stem cells in acute myeloid leukemia
Heo, Sook-Kyoung, Noh, Eui-Kyu, Lan Jeong Ju, Jun Young Sung, Yoo Kyung Jeong, Cheon, Jaekyung, Su Jin Koh, Young Joo Min, Choi, Yunsuk, Jo, Jae-Cheol · 2020 · Figshare
Additional file 1 of Targeting NLRP3 inhibits AML progression by inducing PERK/eIF2-mediated apoptosis
Michela Luciano, Helene Sieberer, Peter William Krenn, Dang, Hieu-Hoa, Julia Vetter, Theresa Neuper, Diana Amend, Constantin Blöchl, Christian X. Weichenberger, Anna Eglseer et al. · 2024 · Figshare
Additional file 1 of CBX2 shapes chromatin accessibility promoting AML via p38 MAPK signaling pathway
Nunzio Del Gaudio, Antonella Di Costanzo, Liu, Ning Qing, Lidio Conte, Carmela Dell’Aversana, Guglielmo Bove, Benedetti, Rosaria, Liliana Montella, Ciardiello, Fortunato, Carafa, Vincenzo et al. · 2022 · Figshare
Additional file 1 of Identification and validation of signal recognition particle 14 as a prognostic biomarker predicting overall survival in patients with acute myeloid leukemia
Shi, Lingling, Huang, Rui, Lai, Yongrong · 2021 · Figshare
Additional file 1 of A statistical network pre-processing method to improve relevance and significance of gene lists in microarray gene expression studies
Giuseppe Agapito, Marianna Milano, Mario Cannataro · 2022 · Figshare
Additional file 1 of CD45dimCD34+CD38−CD133+ cells have the potential as leukemic stem cells in acute myeloid leukemia
Heo, Sook-Kyoung, Noh, Eui-Kyu, Lan Jeong Ju, Jun Young Sung, Yoo Kyung Jeong, Cheon, Jaekyung, Su Jin Koh, Young Joo Min, Choi, Yunsuk, Jo, Jae-Cheol · 2020 · Figshare
Additional file 3 of CD45dimCD34+CD38−CD133+ cells have the potential as leukemic stem cells in acute myeloid leukemia
Heo, Sook-Kyoung, Noh, Eui-Kyu, Lan Jeong Ju, Jun Young Sung, Yoo Kyung Jeong, Cheon, Jaekyung, Su Jin Koh, Young Joo Min, Choi, Yunsuk, Jo, Jae-Cheol · 2020 · Figshare
Additional file 4 of CD45dimCD34+CD38−CD133+ cells have the potential as leukemic stem cells in acute myeloid leukemia
Heo, Sook-Kyoung, Noh, Eui-Kyu, Lan Jeong Ju, Jun Young Sung, Yoo Kyung Jeong, Cheon, Jaekyung, Su Jin Koh, Young Joo Min, Choi, Yunsuk, Jo, Jae-Cheol · 2020 · Figshare
Isocitrate dehydrogenase 1 mutations drive downregulation of IL1R1 and dysregulated inflammatory response in acute myeloid leukemia
Sophie S. Steinhäuser, Thomas Beder, Emely Hübner, Dorothea Sophie Feuereisel, Jonathan Jebens, Nadine Wolgast, Muhammed Bilal Karaca, Kathrin Richter, Nina Hedemann, Britta Steer et al. · 2026 · Blood Cancer Journal
Gene Network Enrichment Analysis and Its Application to Explore Enriched Immune Disease Pathways for Gene Network of Acute Myeloid Leukemia Cell Lines
Heewon Park, Satoru Miyano · 2026 · Journal of Computational Biology
Site-specific methylation of SRSF2 P95H by SETD2 inhibits MDSC-mediated proinflammatory niche formation in mouse models of myelodysplastic syndrome
Zi-Juan Li, Mu-ying Zhao, Roujia Wang, Na Liu, Cheng-Long Hu, Binhe Chang, Fang Hu, Xi-Ya Li, Chunhui Xu, Ping Liu et al. · 2026 · Science Translational Medicine
Implication de l'inflammasome NLRP3 dans la sécrétion non conventionnelle de la protéine FADD
Sara Mouasni · 2018
Modifications du microenvironnement cytokinique dans les leucémies aigües myéloïdes
Hélène Guermouche · 2021 · theses.fr (ABES)
Rôle des cellules stromales périostéales dans la régénération de la niche hématopoïétique
Tony Marchand · 2021 · theses.fr (ABES)
Developmental origins of the ETO2 : GLIS2 - driven acute megakaryoblastic leukemia in humans and role of the cytokine microenvironment in leukemogenesis
Klaudia Galant · 2024 · theses.fr (ABES)
Interleukin-1-mediated inflammatory memory: Protective training or maladaptive tumor imprinting?
Despoina Xanthopoulou, Maria Crespo, Lydia Kalafati · 2026 · Seminars in Immunology
Bone marrow plasma cytokine composition indicates acute myeloid leukemia progression and treatment response
Qiuyu Mo, Guoran Xie, Huang Kangle, Weiye Nie, H Chen, Jie Yang, Chang Liu, Xiayun Su, Qunqian Ning, Jie Chang et al. · 2026 · Frontiers in Cell and Developmental Biology
Leveraging Immunotherapy in Acute Myeloid Leukemia Treatment: Opportunities and Challenges
Wanbin Fu, Juan Du, Hua Zhong · 2026 · Technology in Cancer Research & Treatment
Culture enhanced MSCs to boost haematopoietic engraftment in a model of the post-leukaemic bone marrow niche
Ioannis Angelos Tsigkos, Yusuf Ayten, Penelope M. Tsimbouri, Massimo Vassalli, Manuel Salmerón‐Sánchez, Matthew John Dalby · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
The eco-evolutionary dynamics of acute myeloid leukemia: From clonal games to clinical intervention
Chunmei Ye, Shuying Fu, Juan Li, Jiayin Xue, Jun Li · 2026 · Cancer Treatment and Research Communications
Inflammatory mechanisms in the AML bone marrow niche: From pathogenesis to therapy
Toon Suls, Eva Lion, Florian Van Oers, Eva De Backer, Elena Lasorsa, Sébastien Anguille · 2026 · Cytokine & Growth Factor Reviews
Inflammatory Network Remodeling in AML Is Driven by Neutrophil-Centric Self-Amplifying Circuits
Shuqing Wang, Kaini Shen · 2026 · International Journal of Molecular Sciences
Activated protein C promotes hematopoietic stem and progenitor cell quiescence and engraftment
Simon J Pöllmann, Marcel G. E. Rommel, Leal Oburoglu, Tanja Hirch, Fabiola Valdivia-Francia, Kah Mun Siow, Timon Menzi, Julia Ackva, Franziska Schenk, Matthias J. Neeracher et al. · 2026 · EMBO Molecular Medicine
Inflammation as a central driver in AML pathogenesis and therapy resistance
Hanxi Luo, Yiyang Ding, Shengjin Fan, Xiaojun Huang, Xiangyu Zhao · 2026 · Science China Life Sciences
C-Reactive Protein-to-Albumin Ratio (CAR) as a Prognostic Biomarker in Newly Diagnosed Acute Myeloid Leukemia Treated with Intensive Induction Therapy: A Single-Center Retrospective Cohort Study
Esen Savaş, Aytek Peker, Selin Küçükyurt, Lale Aydın Kaynar, Jale Yıldız, Hacer Berna Afacan Öztürk, Merih Kızıl Çakar, Murat Albayrak, Şahika Zeynep Akı, Ahmet Kürşad Güneş · 2026 · Hitit Medical Journal
Metabolic processes and microenvironmental regulation in leukemia
Binhe Chang, Yong Wang, Zijuan Li, Muying Zhao, Chuhan Deng, Yiyi Ren, Qijing Li, Xiaojian Sun, Lan Wang · 2026 · Chinese Medical Journal
Frequency and Potential Disease-Modifying Role of MEFV Variants in Acute Myeloid Leukemia and Myelodysplastic Syndrome: A Retrospective Case–Control Study
Ömer Işık, Fatih Eren, Ahmet Mert Yanık, Fatma Arıkan, Asu Fergün Yılmaz, Tayfur Toptaş, Mehmet Pamir Atagündüz, Demet Yılmaz Karadağ, Işık Atagündüz · 2026 · Medicina