The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

Schugar, Rebecca C., Shih, Diana M., Warrier, Manya, Helsley, Robert N., Burrows, Amy, Ferguson, Daniel, Brown, Amanda L., Gromovsky, Anthony D. +30 more·2017·Cell Reports
DOI 10.1016/j.celrep.2017.05.077

Cited by (291)

Items 201–291 of 291

  1. The effect of trimethylamine N-oxide on the metabolism of visceral white adipose tissue in spontaneously hypertensive rat
    Guodong He, Xiaocong Liu, Xing-Hua Hou, Yingqing Feng · 2022 · Adipocyte
  2. Evaluation of the Feasibility of In Vitro Metabolic Interruption of Trimethylamine with Resveratrol Butyrate Esters and Its Purified Monomers
    Ping‐Hsiu Huang, Dequan Chen, Yu‐Wei Chen, Ming‐Kuei Shih, Bao‐Hong Lee, You‐Lin Tain, Chang‐Wei Hsieh, Chih‐Yao Hou · 2024 · Molecules
  3. Vanadium-dependent activation of glucose transport in adipocytes by catecholamines is not mediatedviaadrenoceptor stimulation or monoamine oxidase activity
    Jessica Fontaine, Geneviève Tavernier, Nathalie Morin, Christian Carpéné · 2020 · World Journal of Diabetes
  4. Impact of Hypoxia–Hyperoxia Exposures on Cardiometabolic Risk Factors and TMAO Levels in Patients with Metabolic Syndrome
    Afina Bestavashvili, Oleg Stanislavovich Glazachev, Shabnam I. Ibragimova, А. Yu. Suvorov, Alexandros Bestavasvili, Shevket Girey Ibraimov, Xinliang Zhang, Yong Zhang, Chavdar S Pavlov, Е. А. Сыркина et al. · 2023 · International Journal of Molecular Sciences
  5. Mechanistic Insights into Antioxidant Interventions Targeting Obesity-Induced Oxidative Stress in the Pathogenesis and Complications of Type 2 Diabetes Mellitus
    Fani‐Niki Varra, Panagiotis Theodosis‐Nobelos, Viktoria‐Konstantina Varra, Michail N. Varras · 2025 · Current Issues in Molecular Biology
  6. Minor diplotypes of FMO3 might protect children and adolescents from obesity and insulin resistance
    Anita Morandi, Chiara Zusi, Massimiliano Corradi, Francesca Olivieri, Claudia Anita Piona, Elena Fornari, Claudio Maffeis · 2018 · International Journal of Obesity
  7. Gut Microbial Trimethylamine is Elevated in Alcohol-Associated Hepatitis and Contributes to Ethanol-Induced Liver Injury in Mice
    Robert Nathaniel Helsley, Tatsunori Miyata, Anagha Kadam, Venkateshwari Varadharajan, Naseer Sangwan, Emily Huang, Rakhee Banerjee, Amanda L. Brown, Kevin K. Fung, William J. Massey et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  8. Potential and Future Therapeutic Applications of Eicosapentaenoic/Docosahexaenoic Acid and Probiotics in Chronic Low-Grade Inflammation
    Amedeo Amedei, Ingrid Lamminpää, Cinzia Parolini · 2025 · Biomedicines
  9. Divergent Effects of Glycemic Control and Bariatric Surgery on Circulating Concentrations of TMAO in Newly Diagnosed T2D Patients and Morbidly Obese
    Marina Canyelles, Antonio Pérez, Alexandra Junza, Inka Miñambres, Óscar Yanes, Helena Sardà, Noemí Rotllán, Josep Julve, Sònia Benı́tez, José Luis Sánchez‐Quesada et al. · 2022 · Diagnostics
  10. Gut Microbiota and Insulin Resistance: Understanding the Mechanism of Better Treatment of Type 2 Diabetes Mellitus
    Alsalt Al-Busaidi, Omer Alabri, Jaifar Alomairi, Ahmed Elsharaawy, Abdullah Al Lawati, Hanan Al Lawati, Srijit Das · 2024 · Current Diabetes Reviews
  11. Gut Microbiota Metabolite TMAO and Adolescent Cardiometabolic Health: A Cross-sectional Analysis
    Fernando de Quadros Iorra, Paula Godinho Rodrigues, Patrícia Martins Bock, Marina Petrasi Guahnon, Sarah Carobini Werner de Souza Eller, Tiago Franco de Oliveira, Letícia Birk, Patricia de Souza Schwarz, Michele Drehmer, Kátia Vergetti Bloch et al. · 2025 · Journal of the Endocrine Society
  12. Circulating molecules that control brown/beige adipocyte differentiation and thermogenic capacity
    Raissa G. Ludwig, Andrea Livia Silva Rocha, Marcelo A. Mori · 2018 · Cell Biology International
  13. Maternal One-Carbon Nutrient Intake and Risk of Being Overweight or Obese in Their Offspring—A Transgenerational Prospective Cohort Study
    Leonie Helen Bogl, Susanne Strohmaier, Frank B. Hu, Walter Churchill Willett, A. Heather Eliassen, Jaime E. Hart, Qi Sun, Jorge E. Chavarro, Alison E. Field, Eva S. Schernhammer · 2024 · Nutrients
  14. The microbiome-derived metabolite trimethylamine N-oxide is associated with chronic kidney disease risk
    Junyi Jiang, Peng Zhu, Xiaoying Ding, Ligang Zhou, Yuyan Lei, Yuyan Lei, Hao Wang, Lulu Chen, Xiang Li, Yunzhou Fei et al. · 2025 · Applied Microbiology and Biotechnology
  15. Trimethylamine N ‐oxide is elevated in postmenopausal women relative to age‐matched men and premenopausal women among individuals with obesity
    Daniel J. Battillo, Steven K. Malin · 2025 · Experimental Physiology
  16. Crosstalk between the m6A modification and the gut microbiota in lipid metabolism
    Haiyan Chen, Yaolin Ren, Jie Yu, Jing Ren, Yuan Zeng, Yifan Wu, Qian Zhang, Xinhua Xiao · 2025 · Microbiological Research
  17. Associations of trimethylamine N-oxide (TMAO) and its precursors with childhood obesity: a case-control study
    Yao Li, Xiancheng Wang, Manting Chen, Meiqun Xiao, Liya Ma, Tao Zhou, Mengying Wang, Qiying Song · 2025 · BMC Endocrine Disorders
  18. Dysregulation of the Gut-Adipose Tissue-Liver Axis: a Possible Mechanism Behind the Relationship Between Metabolic Dysfunction-Associated Steatotic Liver Disease and Type 2 Diabetes
    Susanna Longo, Tommaso Giovanni Rinaldi, José Manuel Fernández‐Real, Massimo Federici · 2026 · Current Diabetes Reports
  19. Deciphering the role of dietary modifications and gut dysbiosis in Non-Alcoholic Fatty Liver Disease
    Meenakshi Vachher, Kohinoor Kaur, Manisha Marothia, Archana Burman, Deepanjana, Savita Bansal · 2025 · Human Nutrition & Metabolism
  20. Food-derived polysaccharides and anti-obesity effects through enhancing adipose thermogenesis: structure-activity relationships, mechanisms, and regulation of gut microecology
    Zhenyu Wang, Qiyu Xu, Lijuan Hou, Zhiyong He, Mark Christian, Xianjun Dai · 2025 · Critical Reviews in Food Science and Nutrition
  21. Sex Differences in Cardiovascular Impact of Early Metabolic Impairment: Interplay between Dysbiosis and Adipose Inflammation
    Haneen S. Dwaib, Ibrahim AlZaim, Ghina Ajouz, Ali Hussein Eid, Ahmed Fawzy EL‐Yazbi · 2021 · Molecular Pharmacology
  22. Hepatic transcriptional profile reveals the role of diet and genetic backgrounds on metabolic traits in female progenitor strains of the Collaborative Cross
    Myungsuk Kim, M. Nazmul Huda, Annalouise O’Connor, Jody Albright, Blythe P Durbin-Johnson, Brian J. Bennett · 2021 · Physiological Genomics
  23. Trimethylamine-N-oxide: the microbial cue in immune-mediated disorders
    Gauri Mirji, Sajad Ahmad Bhat, Rahul Suresh Shinde · 2026 · Trends in Endocrinology and Metabolism
  24. Multi-trajectories of BMI, waist circumference, gut microbiota, and incident dyslipidemia: a 27-year prospective study
    Xiaofan Zhang, Fangxu Guan, Wanglong Gou, Qi Wang, Shufa Du, Chang Su, Jiguo Zhang, Ju‐Sheng Zheng, Huijun Wang, Bing Zhang · 2025 · mSystems
  25. Vasodilator Dysfunction in Human Obesity: Established and Emerging Mechanisms
    Francesca Schinzari, Manfredi Tesauro, Carmine Cardillo · 2021 · Journal of Cardiovascular Pharmacology
  26. Link between the gut and adipose tissues
    Alan W. J. Morris · 2017 · Nature Reviews Endocrinology
  27. Trimethylamine-N-oxide (TMAO) Selectively Disrupts Endothelium-Dependent Hyperpolarization-Type Relaxations in a Time-Dependent Manner in Rat Superior Mesenteric Artery
    Abdelrahman Hamad, Melike Hacer Özkan, Serdar Uma · 2021 · Biological and Pharmaceutical Bulletin
  28. The Human Microbiome—A Physiologic Perspective
    Xiao Jun Yang, Tijs Louwies, Ruben A. T. Mars, Purna Kashyap · 2024 · Comprehensive physiology
  29. PCSK9 and APOA4 : The Dynamic Duo in TMAO-induced Cholesterol Metabolism and Cholelithiasis
    Chao Shi, Jingjing Yu, Ziang Meng, Da-Yong Lu, Huiru Ding, Haijun Sun, Guangxin Shi, Dongbo Xue, Xianzhi Meng · 2025 · Journal of Clinical and Translational Hepatology
  30. Integrating TMAO into the pathogenesis of obesity and type 2 diabetes: a mini review
    Dana Liana Stoian, Denisa Pescari, Andreea Bena, Corina Paul, Simina Mihuta · 2026 · Frontiers in Clinical Diabetes and Healthcare
  31. Harnessing the gut–heart axis for cardiovascular drug innovation: microbiome, metabolites, and personalized treatment strategies
    Qhelen Mayline Chandra, Davini Clister, Princella Halim, Aminah Dalimunthe, Muhammad Ichwan, Dina Keumala Sari, Chindy Umaya, Nahida Aktary, Amama Rani, Moon Nyeon Park et al. · 2026 · Clinica Chimica Acta
  32. Role of TMAO on Folding Behavior of Various Proteins Associated with Neurodegeneration
    Kritika Kumari · 2024 · Springer eBooks
  33. Associations of the T329S Polymorphism in Flavin-Containing Monooxygenase 3 With Atherosclerosis and Fatty Liver Syndrome in 90-Week-Old Hens
    Jianlou Song, Xuefeng Shi, Xianyu Li, Qianni Liang, Lingsen Zeng, Guangqi Li, Yiyuan Yan, Guiyun Xu, Jiangxia Zheng · 2022 · Frontiers in Veterinary Science
  34. Plasma Cholesterol- and Body Fat-Lowering Effects of Chicken Protein Hydrolysate and Oil in High-Fat Fed Male Wistar Rats
    Thomas Aquinas Aloysius, Veronika Tillander, Matteo Pedrelli, Simon N. Dankel, Rolf Kristian Berge, Bodil Bjørndal · 2022 · Nutrients
  35. Gut Microbiota Perturbation in Early Life Could Influence Pediatric Blood Pressure Regulation in a Sex-Dependent Manner in Juvenile Rats
    Yang Yang, Jinxing Li, Zhimo Zhou, Simou Wu, Jincheng Zhao, Wen Jia, Meixun Liu, Xi Ping Shen, Fang He, Ruyue Cheng · 2023 · Nutrients
  36. The role of gut microbiota on obesity management: a review of the evidence
    Roya Abedi Soleimani, Payam Gonbari Milani, Aziz Homayouni Rad · 2024 · Gastrointestinal Nursing
  37. Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control
    Julien Chilloux, François Brial, Amandine Everard, David R. Smyth, Petros Andrikopoulos, Liyong Zhang, Hubert Plovier, Antonis Myridakis, Lesley Hoyles, José María Moreno‐Navarrete et al. · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  38. Metabotherapy for intestinal disease: using metabolites to prevent and treat disorders of the gut
    Shan Liu, Marina Domingo‐Vidal, Bhoomi Madhu, Dana Binyamin, Christoph A. Thaiss, Maayan Levy · 2026 · Nature Reviews Gastroenterology & Hepatology
  39. The Microbiome Epoch: Cracking the Cardiovascular-Neurodegenerative Disorder Code
    Cinzia Parolini, Amedeo Amedei · 2026 · Frontiers in Bioscience-Landmark
  40. Clinically relevant body composition phenotypes are associated with distinct circulating cytokine and metabolomic milieus in epithelial ovarian cancer patients
    Evan W. Davis, Hua-Hsin Hsiao, Nancy Barone, Spencer R. Rosario, Rikki A. Cannioto · 2024 · Frontiers in Immunology
  41. Role of the Microbiome in Cardiovascular Disease
    Thanat Chaikijurajai, Jennifer D. Wilcox, W.H. Wilson Tang · 2021 · Contemporary cardiology
  42. Food-gut microbiota interactions
    K. Berding, D. Kaulmann, J. Cryan · 2022 · Probiotics
  43. Proteomics-Based Identification of Interaction Partners of the Xenobiotic Detoxification Enzyme FMO3 Reveals Involvement in Urea Cycle
    Zhao Yang, Paul M. Stemmer, Michael C. Petriello · 2022 · Toxics
  44. The gut microbiome in chronic kidney disease
    Ana Merino-Ribas, Carolina F. F. A. Costa, Maria João Azevedo, Inês Soares Alencastre, Manuel Pestana, Ricardo Araújo, Benedita Sampaio‐Maia · 2022 · Elsevier eBooks
  45. Metabolomics Approach to Identify Biomarkers of Epidemic Diseases
    Pooja Rani Mina · 2023 · Springer eBooks
  46. The microbiome and cardiovascular disease: Implications in Precision Medicine
    Zeneng Wang, Lucas J. Osborn · 2023 · Elsevier eBooks
  47. Anti‐Diabetic Intestinal Mechanisms: Foods, Herbs, and Western Medicines
    Yuwei Feng, Hong Cao, Jiao Hua, Feng Zhang · 2022 · Molecular Nutrition & Food Research
  48. Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury
    Venkateshwari Varadharajan, Iyappan Ramachandiran, William J. Massey, Raghav Jain, Rakhee Banerjee, Anthony J. Horak, Megan R. McMullen, Emily Huang, Annette Bellar, Shuhui Wang Lorkowski et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  49. Multi-trajectories of body mass index, waist circumference, gut microbiota, and incident dyslipidemia: a 27-year prospective study
    Xiaofan Zhang, Fangxu Guan, Wanglong Gou, Qi Wang, Shufa Du, Chang Su, Jiguo Zhang, Ju‐Sheng Zheng, Huijun Wang, Bing Zhang · 2024 · Research Square
  50. Porcine gut microbiota and lipid metabolism: recent advances and future directions
    Yanfei Ma, Jianxin Liu, Haifeng Wang · 2022 · Scientia Sinica Vitae
  51. Human microbiome, cancer and cancer therapy
    Ravichandran Veerasamy, Rohini Karunakaran, Smitha Vasu · 2024 · Elsevier eBooks
  52. Porcine jejunal-derived extracellular vesicles participate in the regulation of lipid metabolism
    Yaotian Fan, Hai-Bin Deng, Jia-Hao Zhu, Jun-Yi Luo, Ting Chen, Jia-Jie Sun, Yong-Liang Zhang, Q. Xi · 2025 · Journal of Animal Science and Biotechnology
  53. Longevity-driven hepatic transcriptional programs mediate resilience to diet-induced liver injury in Ames dwarf mice
    Jaspreet Kaur Osan, Sharlene G. Rakoczy, Heidi L. Pecoraro, Holly M. Brown‐Borg · 2025 · GeroScience
  54. The current consensus on ulcerative colitis, and the evidence and perspectives on the influence of gut microbiota on it
    Yufeng Chen, Chang Liu · 2026 · Frontiers in Medicine
  55. Gut microbe-derived trimethylamine shapes circadian rhythms through the host receptor TAAR5
    Kala K. Mahen, William J. Massey, Danny Orabi, Amanda L. Brown, Thomas C. Jaramillo, Amy C Burrows, Anthony J. Horak, Sumita Dutta, Marko Mrdjen, Nour Mouannes et al. · 2025 · eLife
  56. Role of diet in shaping the gut microbiome
    Bilal Siddiqui, Sakshi Tiwari, Saman Fatima, Malik Zainul Abdin · 2026 · Elsevier eBooks
  57. Single- and Multi-Trait GWASs Combined with Genetic Parameter Estimation Reveal Candidate Genes for Body Conformation Traits in Sika Deer (Cervus nippon)
    Hexuan Gao, Tianjiao Wang, Ranran Zhang, X Chen, Huanhuan Fan, Sukun Yang, Shiwu Dong, Handa Zhang, Lixin Tang, Xiumei Xing · 2026 · Animals
  58. Atherosclerotic-dose TMAO accentuates redox imbalances and motor dysfunctions in a MPTP mouse model of Parkinson’s disease
    Paul-Ștefan Panaitescu, Ioana Bâldea, Vlad Alexandru Toma, Alexandra-Maria Nuţu, Claudia-Andreea Moldoveanu, Alexandra Sevastre-Berghian, Ana-Maria Vlase, Irina Camelia Haranguş, Carmen Anca Costache, Simona Valeria Clichici et al. · 2026 · Frontiers in Aging Neuroscience
  59. Gut microbiota interaction in host lipid metabolism
    Rachel M. Golonka, Ahmed A. Abokor, James Mukasa Ntambi, Matam Vijay–Kumar · 2020 · Elsevier eBooks
  60. Impact de la nutrition sur le microbiote intestinal dans la maladie rénale chronique
    Laetitia Koppe, Christophe Olivier Soulage · 2022 · Cahiers de Nutrition et de Diététique
  61. Role of intestinal flora imbalance in formation of abdominal aortic aneurysms
    Xiao Wang, Jiarui Yu, Cui-Hong Tian, Tao Liang · 2024 · World Chinese Journal of Digestology
  62. Decoding the Link: Exploring FMO3 Gene Variations as a Key to Understanding Type Two Diabetes Through Bioinformatics and Case–Control Analyses
    Shahrzad Shokati, Saman Sargazi, Mahdi Majidpour, Shekoufeh Mirinejad, Zari Naderi Ghale-Noie, Mansour Shahraki, Sara Sargazi, Maryam Piri · 2025 · Indian Journal of Clinical Biochemistry
  63. Altered Microbiota and Their Metabolism in Host Metabolic Diseases
    Beng San Yeoh, Matam Vijay–Kumar · 2018 · Springer eBooks
  64. The gut microbial-derived metabolite trimethylamine N-oxide: A missing link between lifestyle-components and atrial fibrillation?
    Monika M. Gawalko, Thomas Jespersen, Dobromir Dobrev, Dominik Linz · 2020 · IJC Heart & Vasculature
  65. Environment-host-microbe interactions shape human metabolism
    Lianmin Chen, Jingyuan Fu · 2021
  66. Membrane Bound O-Acyltransferase 7 (MBOAT7)-Driven Lysophosphatidylinositol (LPI) Acylation in Adipocytes Contributes to Systemic Glucose Homeostasis
    William J. Massey, Venkateshwari Varadharajan, Rakhee Banerjee, Amanda L. Brown, Anthony J. Horak, Rachel C. Hohe, E. Ricky Chan, Calvin Pan, Renliang Zhang, Daniela S. Allende et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  67. Dietary choline activates brown fat to reduce adiposity and cholesterol in APOE*3-Leiden.CETP mice
    Cong Liu, Zikuan Song, Li Zhuang, Mariëtte R. Boon, Milena Schönke, Patrick C.N. Rensen, Yanan Wang · 2022 · Research Square
  68. Gut Microbial Metabolite Trimethylamine-N-Oxide and Its Role in Cardiovascular Diseases
    Shubham Barik, Aritra Mukherjee, Angelina Job Kolady, Boda Karunakar, Tony Grace · 2022 · IntechOpen eBooks
  69. Trimethylamine N-oxide impairs β-cell function and glucose tolerance
    Lijuan Kong, Qijin Zhao, Xiaojing Jiang, Qian Jiang, Sheng Li, xiaohong peng, Shusen Wang, Yibing Chen, Shaocong Hou, Xingfeng Liu et al. · 2023 · Research Square
  70. Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury
    Venkateshwari Varadharajan, Iyappan Ramachandiran, William J. Massey, Raghav Jain, Rakhee Banerjee, Anthony J. Horak, Megan R. McMullen, Emily Huang, Annette Bellar, Shuhui Wang Lorkowski et al. · 2023 · eLife
  71. Monoamine Oxidases and Flavin-Containing Monooxygenases
    John Richard Cashman · 2024 · Elsevier eBooks
  72. Membrane Bound O-Acyltransferase 7 (MBOAT7) Shapes Lysosomal Lipid Homeostasis and Function to Control Alcohol-Associated Liver Injury
    Venkateshwari Varadharajan, Iyappan Ramachandiran, William J. Massey, Raghav Jain, Rakhee Banerjee, Anthony J. Horak, Megan R. McMullen, Emily Huang, Annette Bellar, Shuhui Wang Lorkowski et al. · 2024 · eLife
  73. Cardiovascular metabolomics
    Ana Nogal, Panayiotis Louca, Ana Maria Valdes, Sandosh Padmanabhan, Cristina Menni · 2024 · Elsevier eBooks
  74. Human microbiome, obesity and cardiovascular diseases
    Miriam Emily Piansay‐Soriano, Shannon Kimberly Soriano, Benjamin V. Pague, Marieldo S. Platero, Maria Angelica Candelario-Plata, Michael Karl M. Calunsag · 2024 · Elsevier eBooks
  75. The effect of elevated levels of the gut metabolite TMAO on glucose metabolism after sleeve gastrectomy
    Zhiping Huang, Chaoqian Liu, Xiang Zhao, Yan Hua Guo · 2025 · Archives of Physiology and Biochemistry
  76. The association between trimethylamine N-Oxide (TMAO) and kynurenine (KYN) and atherogenic indices and body composition in adults: a cross-sectional study
    Atieh Mirzababaei, Maryam Sadat Mahmoodi, Faezeh Abaj, Sara Ebrahimi, Mahsa Samadi, Pardis Khalili, Azam Mohamadi, Zeinab Zarrinvafa, Khadijeh Mirzaei · 2025 · Nutrire
  77. Additional file 1 of Serum trimethylamine-N-oxide is associated with incident type 2 diabetes in middle-aged and older adults: a prospective cohort study
    Li, Shu-yi, Si Chen, Lu, Xiao-ting, Fang, Ai-ping, Chen, Yu-ming, Huang, Rong-zhu, Lin, Xin-lei, Huang, Zi-hui, Ma, Jing-fei, Huang, Bi-xia et al. · 2022 · Figshare
  78. The Novel Triad of Atherosclerosis, ACE2, and Dysbiosis: A literature Review
    V. Prabhakaran, V. Poovizhi, Vipin Kumar Verma, Amalkrishnan Therayil, Jagriti Bhatia, DS Arya · 2025 · Life Sciences
  79. Steric and Electronic Effects in the Enzymatic Catalysis of Choline-TMA Lyase
    Valentin Gogonea, Stanley L. Hazen · 2025 · Biomolecules
  80. Neuronal lipidome in schizophrenia and metabolic syndrome: Potential interventions
    Adonis Sfera, Edelina Turturica, Dragos Turturica, Ioana Ciuperca, Daniel Ikhimiukor, Jacob Anton, Bernardo Bozza, Garth L. Nicolson · 2026 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
  81. Circulating microbiome and its clinical implications in diabetes mellitus: Mechanistic insights and therapeutic perspectives
    Dinakaran Vasudevan · 2026 · World Journal of Diabetes
  82. The role of gut microbiome-produced trimethylamine in targeting insulin resistance
    Tianru Jin · 2026 · Obesity Medicine
  83. Blood Focused-Metabolomics and Transcriptomics Uncover Non-Linear Risk Association of Inadequate Dietary Choline Intake-Linked Metabolic Stress with MASLD Through Amino Acid Biomarkers, BCAA and MTORC 1/AKT1/IRS1 Mechanistic Mediators: A Nested Case–Control Study
    Chien‐Hsien Wu, Ming‐Lu Lin, Chao-Yun Wang, Chi-Yang Chang, Fu‐Jen Lee, Mei‐Ling Cheng, Yu‐Shun Lin, T Chen, Yi-Ting Hsiao, Bei-Wen Wang et al. · 2026 · International Journal of Molecular Sciences
  84. Nutritional Factors Affecting Uremic Toxin Production
    Fanny Jouve, Christophe Olivier Soulage, Laetitia Koppe · 2026 · Toxins
  85. Microbiota-derived TMAO links PM 2.5 exposure to cognitive impairment: A gut–liver–brain axis
    Hussain Akhlaq, Yunxiao Zhong, Shicong Du, Zonghao Ma, Tong Cheng, Jiasui Yu, Lee Cheuk Hin, Douglas Affonso Formolo, Patrick K. H. Lee, Baomin Wang et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  86. Dietary choline intake during pregnancy and birth weight in a Chinese population: a cross-sectional study
    Jiaomei Yang, Ziqi Xiao, Wanting Hu, Baligen Rekemubieke, Yue-Hua Li · 2026 · Nutrition Journal
  87. Divergence between circulating trimethylamine and trimethylamine-N-oxide associated with common flavin-containing monooxygenase 3 variation
    Justin Tang, Joshua A. Zaretsky, Jaden D. Labajo, Abir Shaqo, Hamza Dakroub, Gia V. Shelp, Elizabeth M. Poole, Sarah E. Burns, Clara E. Cho · 2026 · iScience
  88. The impact of climatic extreme temperatures on gut microbiome-mediated cardio-metabolic health
    Avaneesh Shukla, Devansh Rughwani, Abhishek Kumar Aditya, Ashwini Kumar Ray · 2026 · Environmental Pollution
  89. Hepatic FMO3 Downregulation Contributes to the Metabolic Benefits of Vertical Sleeve Gastrectomy
    Hai Yan, Chong Cao, Xiaozhuo Tan, Xianjue Huang, Yanyang Liu, Yuxiao Chu, Min He, Qiyuan Yao, Rong Hua, Yikai Shao · 2026 · Obesity
  90. Choline and metabolic health, a missing link in a critical chain
    Evan M. Paules · 2026 · Current Opinion in Clinical Nutrition & Metabolic Care
  91. Targeting Gut Microbiota, Inflammation, and Metabolic Dysfunction-Associated Steatotic Liver Disease in Type 2 Diabetes Mellitus: Therapeutic Strategies and the Emerging Role of Time-Restricted Feeding
    Sthembiso Msane, Andile Khathi · 2026 · Cells