Differential effector engagement by oncogenic KRAS
Yuan, Tina L., Amzallag, Arnaud, Bagni, Rachel, Yi, Ming, Afghani, Shervin, Burgan, William, Fer, Nicole, Strathern, Leslie A. +22 more·2018·Cell Reports
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- Limited role of KRAS mutation in guiding immunotherapy in advanced non-small-cell lung cancerHong‐Shuai Li, Chengming Liu, Yan Wang · 2022 · Future Oncology
- Oncogenic KRAS engages an RSK1/NF1 complex in pancreatic cancerDerek K. Cheng, Tobiloba E. Oni, Youngkyu Park, Jennifer S. Thalappillil, Hsiu-Chi Ting, Brinda Alagesan, Nadia V. Prasad, Keith D. Rivera, Darryl Pappin, Linda Van Aelst et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
- Exploring the role of monocarboxylate transporter 4 in diverse KRAS mutation subtypes of colorectal CancerQian Gong, Jing Huang, Qingshu Li, Shuxian Zhang, Ming Xiao, Ming Li, Yaying Yang, Yi Ping Tang, Yalan Wang · 2025 · Scientific Reports
- FOXO1 links KRAS G12D and G12V alleles to glutamine and nitrogen metabolism in colorectal cancerSuzan Ber, Ming Hui Yang, Marco Sciacovelli, Shamith Samarajiwa, Khushali Patel, Efterpi Nikitopoulou, Annie Howitt, Simon J. Cook, Ashok R. Venkitaraman, Christian Frezza et al. · 2025 · EMBO Reports
- Tumor suppressor genes and KRAS G12C inhibitor resistance in non-small cell lung cancerLinsha Zhu, Xiangbo Jia, Lei Xu, Li Chen, Xiangning Fu, Hua Yan, Bo Ai, Shu Peng · 2025 · iScience
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- STAT3 sustains tumorigenicity following mutant KRAS ablationStephen D’Amico, Varvara Kirillov, Jingxuan Liu, Zhijuan Qiu, Xinyuan Lei, Hong Qin, Brian S. Sheridan, Nancy C. Reich · 2025 · EMBO Reports
- STAT3 is a genetic modifier of TGF-beta induced EMT in KRAS mutant pancreatic cancerStephen D’Amico, Varvara Kirillov, Oleksi Petrenko, Nancy C. Reich · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- TIMP-1 Modulation Correlates with KRAS Dependency and EMT Induction in NSCLCIlamathi M-Thirusenthilarasan, Pankaj Kumar Ahluwalia, Nithyananda Thorenoor, Sampa Ghoshal-Gupta, Byung Rho Lee, Bilal Karim Siddiqui, Ravindra B Kolhe, Amyn M. Rojiani, Mumtaz V. Rojiani · 2025 · Cells
- RAS mutations and colorectal cancer metabolism: a metabolomic analysis of tissue samplesJianjiong Li, Buyuan Dong · 2025 · BMC Cancer
- Understanding the performance of HIV-1 viral vector vaccines: adenovirus and poxvirus case studiesMahdiyeh M. Manafi, Touraj Aligholipour Farzani, Nallely Espinoza, Al Ozonoff, Pardis Christine Sabeti · 2026 · Frontiers in Immunology
- Identification of BIK as an unfavorable prognostic marker and novel therapeutic target in microsatellite stable colorectal cancer harboring KRAS mutations.Peng Liu, Feng Jiao, Zhenghua Zhang, Feilong Zhao, Jinping Cai, Shiqing Chen, Tao Fu, Min Li · 2022 · PubMed Central
- KRAS-mutated non-small cell lung cancer: new therapy strategiesКонстантин Константинович Лактионов, К. А. Саранцева, Нелюбина Лидия Александровна, S. V. Gamayunov, Е. А. Kolesnikova, M. Gordiev · 2024 · Siberian Journal of Oncology
- Targeted phosphoproteomics of the Ras signaling network reveal regulatory mechanisms mediated by oncogenic KRASAnatoly Urisman, Tina L. Yuan, Marena I. Trinidad, John H. Morris, Shervin Afghani, Juan A. Osés-Prieto, Cayde D. Ritchie, Muhammad Saddiq Zahari, Cyril H. Benes, Alma L. Burlingame et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
- Phosphoinositide 3-kinase regulates wild-type RAS signaling to confer resistance to KRAS inhibitionXiangyu Ge, Jaffarguriqbal Singh, Wenxue Li, Cassandra Santaella Bishop, Christian Felipe Ruiz, Moitrayee Bhattacharyya, Yansheng Liu, Mandar Deepak Muzumdar · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Mapping Effector–Phenotype Landscapes in KRAS-Driven CancersPeter S. Winter, Kris C. Wood · 2018 · Trends in cancer
- Examining the markers of vitamin C cytotoxicity in pancreatic ductal adenocarcinomaCassia Warren · 2019 · cIRcle (University of British Columbia)
- Faculty Opinions recommendation of RAC1P29S induces a mesenchymal phenotypic switch via serum response factor to promote melanoma development and therapy resistance.Jonathan Chernoff · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Faculty Opinions recommendation of RAC1P29S induces a mesenchymal phenotypic switch via serum response factor to promote melanoma development and therapy resistance.Paul Timpson, David Herrmann · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Lung Cancer and KRAS -Its Molecular Biology/Genetics and Therapeutic Strategy-Takamasa Koga, Tetsuya Mitsudomi · 2022 · Haigan
- Evaluation of K-Ras4B dimer interfaces and the role of Raf effectorsAlexios Chatzigoulas, Ioannis Andreadelis, Stefan Doerr, Christos Lamprakis, Anastasia Theodoropoulou, John I. Manchester, Camilo Velez‐Vega, José S. Duca, Zoe Cournia · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Data from Scaffolding Protein Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) Regulates MAPK Inhibition Responsiveness in Pancreas Cancer via Crosstalk with AKT SignalingDandan Li, Anne M. Miermont, Rushikesh V. Sable, Humair S. Quadri, Lesley A. Mathews Griner, Scott E. Martin, Taivan Odzorig, Soumita De, Marc Ferrer, Astin S. Powers et al. · 2023
- Data from Vertical Inhibition of the RAF–MEK–ERK Cascade Induces Myogenic Differentiation, Apoptosis, and Tumor Regression in H/NRASQ61X Mutant RhabdomyosarcomaNatalia García, Vanessa Del Pozo, Marielle E. Yohe, Craig M. Goodwin, Terry J. Shackleford, Long Wang, Kunal Baxi, Yidong Chen, Anna T. Rogojina, Sara M. Zimmerman et al. · 2023
- Data from Vertical Inhibition of the RAF–MEK–ERK Cascade Induces Myogenic Differentiation, Apoptosis, and Tumor Regression in H/NRASQ61X Mutant RhabdomyosarcomaNatalia García, Vanessa Del Pozo, Marielle E. Yohe, Craig M. Goodwin, Terry J. Shackleford, Long Wang, Kunal Baxi, Yidong Chen, Anna T. Rogojina, Sara M. Zimmerman et al. · 2023
- Data from Scaffolding Protein Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) Regulates MAPK Inhibition Responsiveness in Pancreas Cancer via Crosstalk with AKT SignalingDandan Li, Anne M. Miermont, Rushikesh V. Sable, Humair S. Quadri, Lesley A. Mathews Griner, Scott E. Martin, Taivan Odzorig, Soumita De, Marc Ferrer, Astin S. Powers et al. · 2023
- Supplementary Figure S10 from Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLCMarcelo Vailati Negrao, Haniel Alves Araújo, Giuseppe Lamberti, Alissa Jamie Cooper, Neal S. Akhave, Teng Zhou, Lukas Delasos, James Kevin Hicks, Mihaela D. Aldea, Gabriele Minuti et al. · 2023
- Supplementary Figure S10 from Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLCMarcelo Vailati Negrao, Haniel Alves Araújo, Giuseppe Lamberti, Alissa Jamie Cooper, Neal S. Akhave, Teng Zhou, Lukas Delasos, James Kevin Hicks, Mihaela D. Aldea, Gabriele Minuti et al. · 2023
- Supplementary Figure S10 from Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLCMarcelo Vailati Negrao, Haniel Alves Araújo, Giuseppe Lamberti, Alissa Jamie Cooper, Neal S. Akhave, Teng Zhou, Lukas Delasos, James Kevin Hicks, Mihaela D. Aldea, Gabriele Minuti et al. · 2023
- Supplementary Figure S10 from Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLCMarcelo Vailati Negrao, Haniel Alves Araújo, Giuseppe Lamberti, Alissa Jamie Cooper, Neal S. Akhave, Teng Zhou, Lukas Delasos, James Kevin Hicks, Mihaela D. Aldea, Gabriele Minuti et al. · 2023
- Regulation and therapeutic targeting of MTHFD2 and EZH2 in KRAS mutated human pulmonary adenocarcinomaYuchan Li · 2023
- STAT3 is a genetic modifier of TGF-beta induced EMT in KRAS mutant pancreatic cancerStephen D’Amico, Varvara Kirillov, Oleksi Petrenko, Nancy C. Reich · 2024 · eLife
- KRAS mutation-selective requirement for ACSS2 in colorectal adenoma formation.Jonathan Chernoff, Konstantin Budagyan, Alexa Christine Cannon, Adam G. Chatoff, Nathaniel W. Snyder, Alison Kurimchak, James S. Duncan · 2024 · Research Square
- Recombinant strains of oncolytic vaccinia virus for cancer immunotherapyYasmin Shakiba, Pavel O. Vorobyev, M. Mahmoud, A. Hamad, Д. В. Кочетков, Gaukhar M. Yusubalieva, Vladimir P. Baklaushev, Peter M. Chumakov, Anastasiya V. Lipatova · 2023 · Biochemistry (Moscow)
- Author Response: STAT3 is a genetic modifier of TGF-beta induced EMT in KRAS mutant pancreatic cancerStephen D’Amico, Varvara Kirillov, Oleksi Petrenko, Nancy C. Reich · 2024 · eLife
- An Evolving Landscape: New Therapies for Metastatic Colorectal CancerChristiana Mo, Bhawneet Chadha, Chaoyuan Kuang · 2024 · Clinical Colorectal Cancer
- Mediating kinase activity in Ras-mutant cancer: potential for an individualised approach?Fiona M. Healy, Amy L. Turner, Vanessa Marensi, David J. MacEwan · 2024 · Frontiers in Pharmacology
- Introduction to RAS biologyChanning J. Der, Frank McCormick · 2024 · Elsevier eBooks
- KRAS G12 mutant alleles differentially control glutamine metabolism via FOXO1Suzan Ber, Ming Hui Yang, Marco Sciacovelli, Shamith Samarajiwa, Khushali Patel, Efterpi Nikitopoulou, Annie Howitt, Simon J. Cook, Ashok R. Venkitaraman, Christian Frezza et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- The Ral small GTPase is an essential regulator of exocyst complex function in secretionYou Wu, David J. Reiner · 2026 · The Journal of Cell Biology
- Cooperativity between Ras pathway mutations in colonic tumorigenesisChristian William Johnson, Anna Idelevich, Bing Shui, Alison W. Tisdale, Eve O’Donoghue, Joshua Cook, Shannon Hull, Moon Hee Yang, Shikha Sheth, Elizabeth M. Terrell et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Remodeling of KRAS interactome induced by clinically relevant RAS inhibitors reveals convergent responses and a KRAS-mediated regulation of directional cell migrationYang Yang, Charles Y. Cho, Ansgar Brock, Doug Quackenbush, Kaisheng Chen, Frederick Lo, Cyril H. Benes, Jacob R. Haling · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- STRUCTURE-BASED OPTIMIZATION OF ADAGRASIB (MRTX849) ANALOGUES: ADVANCED COMPUTATIONAL FRAMEWORK FOR KRAS G12D INHIBITOR DESIGNAyşegül Varol · 2025 · Mugla Journal of Science and Technology
- Deciphering the metabolic bases of Drosophila intestinal tumorsPierre Delamotte · 2024 · theses.fr (ABES)
- Functional Interpretation of Differential Gene Expression in Cancer: From Lists to MechanismsAmancio Carnero · 2026 · Gene Expression
- Chronic cigarette smoke exposure induces distinct stem cell states driving genetic driver–specific non–small cell lung cancer subtypesNa Wang, Raksha Padaki, Sara-Jayne Thursby, Ray-Whay Chiu Yen, Leslie Cope, Malcolm V. Brock, Edward W. Gabrielson, Hariharan Easwaran, Stephen B. Baylin, Michelle J. Vaz · 2026 · Proceedings of the National Academy of Sciences
- Dynamic remodeling of the KRAS interactome by direct RAS inhibitors with distinct mechanism of action reveals convergent responsesYang Yang, TingYu Liu, Charles Y. Cho, Xianzhong Liu, Ansgar Brock, Doug Quackenbush, Kaisheng Chen, Frederick Lo, Cyril H. Benes, Jacob R. Haling · 2026 · Oncogene
- BindingDB Entry 50016438: Recent advances of human dihydroorotate dehydrogenase inhibitors for cancer therapy: Current development and future perspectives.BindingDB · 2023 · UC San Diego