Differential effector engagement by oncogenic KRAS

Yuan, Tina L., Amzallag, Arnaud, Bagni, Rachel, Yi, Ming, Afghani, Shervin, Burgan, William, Fer, Nicole, Strathern, Leslie A. +22 more·2018·Cell Reports

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  11. STAT3 sustains tumorigenicity following mutant KRAS ablation
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  12. STAT3 is a genetic modifier of TGF-beta induced EMT in KRAS mutant pancreatic cancer
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  13. TIMP-1 Modulation Correlates with KRAS Dependency and EMT Induction in NSCLC
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  15. Understanding the performance of HIV-1 viral vector vaccines: adenovirus and poxvirus case studies
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  16. Identification of BIK as an unfavorable prognostic marker and novel therapeutic target in microsatellite stable colorectal cancer harboring KRAS mutations.
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  17. KRAS-mutated non-small cell lung cancer: new therapy strategies
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  18. Targeted phosphoproteomics of the Ras signaling network reveal regulatory mechanisms mediated by oncogenic KRAS
    Anatoly Urisman, Tina L. Yuan, Marena I. Trinidad, John H. Morris, Shervin Afghani, Juan A. Osés-Prieto, Cayde D. Ritchie, Muhammad Saddiq Zahari, Cyril H. Benes, Alma L. Burlingame et al. · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  19. Phosphoinositide 3-kinase regulates wild-type RAS signaling to confer resistance to KRAS inhibition
    Xiangyu Ge, Jaffarguriqbal Singh, Wenxue Li, Cassandra Santaella Bishop, Christian Felipe Ruiz, Moitrayee Bhattacharyya, Yansheng Liu, Mandar Deepak Muzumdar · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  20. Mapping Effector–Phenotype Landscapes in KRAS-Driven Cancers
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  21. Examining the markers of vitamin C cytotoxicity in pancreatic ductal adenocarcinoma
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  22. Faculty Opinions recommendation of RAC1P29S induces a mesenchymal phenotypic switch via serum response factor to promote melanoma development and therapy resistance.
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  26. Data from Scaffolding Protein Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) Regulates MAPK Inhibition Responsiveness in Pancreas Cancer via Crosstalk with AKT Signaling
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  29. Data from Scaffolding Protein Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) Regulates MAPK Inhibition Responsiveness in Pancreas Cancer via Crosstalk with AKT Signaling
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  30. Supplementary Figure S10 from Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLC
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  31. Supplementary Figure S10 from Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLC
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  32. Supplementary Figure S10 from Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLC
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  34. Regulation and therapeutic targeting of MTHFD2 and EZH2 in KRAS mutated human pulmonary adenocarcinoma
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  35. STAT3 is a genetic modifier of TGF-beta induced EMT in KRAS mutant pancreatic cancer
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  36. KRAS mutation-selective requirement for ACSS2 in colorectal adenoma formation.
    Jonathan Chernoff, Konstantin Budagyan, Alexa Christine Cannon, Adam G. Chatoff, Nathaniel W. Snyder, Alison Kurimchak, James S. Duncan · 2024 · Research Square
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  38. Author Response: STAT3 is a genetic modifier of TGF-beta induced EMT in KRAS mutant pancreatic cancer
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  42. KRAS G12 mutant alleles differentially control glutamine metabolism via FOXO1
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  45. Remodeling of KRAS interactome induced by clinically relevant RAS inhibitors reveals convergent responses and a KRAS-mediated regulation of directional cell migration
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  46. STRUCTURE-BASED OPTIMIZATION OF ADAGRASIB (MRTX849) ANALOGUES: ADVANCED COMPUTATIONAL FRAMEWORK FOR KRAS G12D INHIBITOR DESIGN
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  50. Dynamic remodeling of the KRAS interactome by direct RAS inhibitors with distinct mechanism of action reveals convergent responses
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