Subregion-specific proteomic signature in the hippocampus for recognition processes in adult mice
Open accessAbstract
The hippocampal formation is a brain structure essential for higher-order cognitive functions. It has a complex anatomical organization and cellular composition, and hippocampal subregions have different properties and functional roles. In this study, we used SWATH-MS to determine whether the proteomes of hippocampus areas CA1 and CA3 can explain the commonalities or specificities of these subregions in basal conditions and after recognition memory. We show that the proteomes of areas CA1 and CA3 are largely different in basal conditions and that differential changes and dynamics in protein expression are induced in these areas after recognition of an object or object location. While changes are consistent across both recognition paradigms in area CA1, they are not in area CA3, suggesting distinct proteomic responses in areas CA1 and CA3 for memory formation.
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Memories for NOP and OPP explicitly altered CA1 and CA3 proteomes, in which the changes of protein expression were largely consistent in CA1 across the two forms of memory, but distinct in CA3.
“In addition, memories for NOP and OPP explicitly altered CA1 and CA3 proteomes, in which the changes of protein expression were largely consistent in CA1 across the two forms of memory, but distinct in CA3.”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as von Ziegler et al., 2018
Studies on proteomes of hippocampal areas CA1 and CA3 showed a different level of expression for ~31% (532 proteins out of 1697 ones) after an open field exploration.
“Studies on proteomes of hippocampal areas CA1 and CA3 were found to show a different level of expression for ~ 31% (532 proteins out of 1697 ones) after an open field exploration.”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as von Ziegler et al., 2018
Specialized proteomic roles of CA1 and CA3 areas contribute to recognition memory.
“These results suggest that specialized proteomic roles of CA1 and CA3 areas contribute to recognition memory (von Ziegler et al., 2018).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as von Ziegler et al., 2018
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References 70 · Cited by 23
- Authors
- von Ziegler, L. M., Selevsek, N., Tweedie-Cullen, R. Y., Kremer, E., & Mansuy, I. M.
- Affiliations
- University of Zurich (CH)
- Corresponding author
- Mansuy, Isabelle M.
- ORCID
- Mansuy, Isabelle M.
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2018-03
- Volume
- 22
- Issue
- 12
- Pages
- 3362-3374
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2791787688
- Cited by
- 23
- References
- 70
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 4
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- ResearchSpace (University of Auckland) (submittedVersion, cc-by-nc-nd)
- Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by-nc-nd)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by-nc-nd)
- ETH Zürich Research Collection
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Nr 31003A_153147/1)
- Universität Zürich
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampus, hippocampal subfields, CA1, CA3, proteomic signatures, recognition memory, object recognition, memory formation, protein expression dynamics, SWATH-MS
- MeSH terms
- Animals, Hippocampus, Proteomics, Mice
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