Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis

Garcia-Reitboeck, Pablo, Phillips, Alexandra, Piers, Thomas M., Villegas-Llerena, Claudio, Butler, Matt, Mallach, Anna, Rodrigues, Celia, Arber, Charles E. +7 more·2018·Cell Reports

Cited by (162)

Items 101–162 of 162

  1. Differential LRRK2 Signalling and Gene Expression in WT-LRRK2 and G2019S-LRRK2 Mouse Microglia Treated with Zymosan and MLi2
    Iqra Nazish, Adamantios Mamais, Anna Mallach, Conceição Bettencourt, Alice Kaganovich, Thomas T. Warner, John Hardy, Patrick Alfryn Lewis, Jennifer M. Pocock, Mark Cookson et al. · 2023 · Cells
  2. Emerging Models to Study Human Microglia In vitro
    Henna Jäntti, Lois Kistemaker, Alice Buonfiglioli, Lot D. de Witte, Tarja Malm, Elly M. Hol · 2024 · Advances in neurobiology
  3. Exploring cellular heterogeneity: single-cell and spatial transcriptomics of Alzheimer's disease brains and iPSC-derived microglia
    Anjali Garg, Sheeny Vo, Iara Dantas de Souza, Ayslan Castro Brant, Logan Brase, Ekaterina Aladyeva, Ricardo D’Oliveira Albanus, Aasritha Nallapu, Hongjun Fu, Oscar Harari · 2025 · Alzheimer s Research & Therapy
  4. Human-Induced Pluripotent Stem Cell–Based Models for Studying Sex-Specific Differences in Neurodegenerative Diseases
    Erkan Kiris · 2021 · Advances in experimental medicine and biology
  5. The role of triggering receptor expressed on myeloid cells 2 in Parkinson’s disease and other neurodegenerative disorders
    Hannah Schwarz, Sarah Bässler, Denise Balta, Eileen Socher, Friederike Zunke, Philipp Arnold · 2022 · Behavioural Brain Research
  6. In vitro Quantitative Imaging Assay for Phagocytosis of Dead Neuroblastoma Cells by iPSC-Macrophages
    Hazel Hall‐Roberts, Elena Di Daniel, William James, John B. Davis, Sally A. Cowley · 2021 · Journal of Visualized Experiments
  7. In vitro Quantitative Imaging Assay for Phagocytosis of Dead Neuroblastoma Cells by iPSC-Macrophages
    Hazel Hall‐Roberts, Elena Di Daniel, William James, John B. Davis, Sally A. Cowley · 2021 · Journal of Visualized Experiments
  8. The downregulation of TREM2 exacerbates toxicity of development and neurobehavior induced by aluminum chloride and nano-alumina in adult zebrafish
    Ying Zhang, Xinyue Guo, Jinjin Zhao, Xiaocheng Gao, Lan Zhang, Tao Huang, Yanhong Wang, Q. L. Niu, Qinli Zhang · 2024 · Toxicology and Applied Pharmacology
  9. Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementia
    Charles Arber, Jackie M. Casey, Samuel Crawford, Naiomi Rambarack, Ümran Yaman, Sarah Wiethoff, Emma Augustin, Thomas M. Piers, Matthew Price, Agueda A. Rostagno et al. · 2024 · Acta Neuropathologica
  10. Lactobacillus for ribosome peptide editing cancer
    Shousong Yue, Qiuxia He, Jean‐François Picimbon · 2023 · Clinical & Translational Oncology
  11. Leveraging iPSC technology to assess neuro-immune interactions in neurological and psychiatric disorders
    Christina Michalski, Zhexing Wen · 2023 · Frontiers in Psychiatry
  12. Expanding the neuroimmune research toolkit with in vivo brain organoid technologies
    Ai Tian, Afrin Bhattacharya, Julien Muffat, Yun Li · 2025 · Disease Models & Mechanisms
  13. Human myeloid progenitor glucocorticoid receptor activation causes genomic instability, type 1 IFN ‐ response pathway activation and senescence in differentiated microglia; an early life stress model
    Jingzhang Wei, Charles Arber, Selina Wray, John Hardy, Thomas M. Piers, Jennifer M. Pocock · 2022 · Glia
  14. Translational regulation and protein-coding capacity of the 5′ untranslated region of human TREM2
    Motoaki Yanaizu, Haruka Adachi, Makoto Araki, Kenji Kontani, Yoshihiro Kino · 2023 · Communications Biology
  15. microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patients
    Penning, Amber, Snoeck, Sarah, Ormaechea, Olmo Ruiz, Ayyildiz, Dilara, Polzer, Oliver, Buitrago-Arango, Martin, Capobianco, Raffaella, de Winter, Fred, Balusu, Sriram, Verhaagen, Joost et al. · 2026 · Acta Neuropathologica Communications
  16. Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis
    Oliver Jonathan Ziff, Sarah Jolly, Jackie M. Casey, Lucy Granat, Satinder Samra, Núria Setó‐Salvia, Argyro Alatza, Leela Phadke, Benjamin Galet, Philippe Ravassard et al. · 2025 · Molecular Neurodegeneration
  17. Microglial Drivers of Alzheimer's Disease Pathology: An Evolution of Diverse Participating States
    Madison K. Kuhn, Elizabeth A. Proctor · 2024 · Proteins Structure Function and Bioinformatics
  18. TSPO PET Imaging as a Biomarker of Neuroinflammation in Neurodegenerative Disorders
    Eryn L. Werry, Fiona Bright, Michael Kassiou · 2021 · Neuromethods
  19. Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson’s disease
    James R. Evans, Melissa Grant‐Peters, Joseph S. Beckwith, Christina E. Toomey, Rebeka Popovic, Jonathan C. Breiter, Jonathan Brenton, Aine Fairbrother-Browne, Stephanie Strohbuecker, Joanne Lachica et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  20. First-in-class SAM-competitive G9a inhibitor FLAV-27 as a disease-modifying therapy for Alzheimer disease
    Aina Bellver‐Sanchís, David Valle‐García, Carla Barbaraci, Fernando Romero-Becerra, Rohit Kumar Singh, Júlia Jarné‐Ferrer, Foteini Vasilopoulou, Alba Irisarri, Carmen Martínez-Fernández, Juan A. Fafián-Labora et al. · 2025 · Molecular Therapy
  21. A critical guideline for controlling monocyte-derived macrophages phenotypes
    Giorgia Moschetti, Doriana Oliveri, Valeria De Matteis, Marta Zaccaria, Diego Rondelli, Anna Griego, Edoardo Scarpa, Loris Rizzello · 2026 · Frontiers in Immunology
  22. Microglia Detect Externalized Phosphatidylserine on Synapses for Elimination via TREM2 in Alzheimer’s Disease Models
    Javier Rueda‐Carrasco, Dimitra Sokolova, Sang‐Eun Lee, Thomas Childs, Natália Jurčáková, Sebastiaan De Schepper, Judy Z. Ge, Joanne Lachica, Christina E. Toomey, Oliver J. Freeman et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  23. A scoping review of stem cell models of leukodystrophies: advances in understanding pathophysiological mechanisms
    Alexandra Chapleau, Stefanie Perrier, Thomas M. Durcan, Geneviève Bernard · 2025 · npj Genomic Medicine
  24. Tissue signatures of human macrophages during homeostasis and activation
    Daniel P. Caron, William L. Specht, Siddhi Nargund, David Chen, Steven B. Wells, Jennifer Hwu, Peter Anthony Szabo, Peter A. Sims, Donna L. Färber · 2025 · The Journal of Immunology
  25. Alterations in the brain lipidome of Alzheimer's disease donors with rare TREM2 risk variants
    Petroula Proitsi, Amera Ebshiana, Asger Wretlind, Jin Xu, Angela Hodges, Cristina Legido‐Quigley · 2026 · Brain Communications
  26. Anatomical location of injected microglia in different activation states and time course of injury determines survival of retinal ganglion cells after optic nerve crush
    Ahad M. Siddiqui, Thomas F. Sabljic, Alexander K. Ball · 2022 · International Journal of Neuroscience
  27. Advancing novel therapies for neurodegeneration through an innovative model for industry–academia collaborations: A decade of the Eisai–UCL experience
    Peter J. Atkinson, Meera Swami, Nicola Ridgway, Malcolm Roberts, Jane Kinghorn, Thomas T. Warner, James M. Staddon, Andrew K. Takle · 2023 · Drug Discovery Today
  28. Human induced pluripotent stem cell– based modeling of Alzheimer’s disease, a glial perspective
    Xianwei Chen, Qingqiu Yang, Zhenqing Liu, Yanhong Shi · 2021 · Elsevier eBooks
  29. Modeling neurological disease using human stem cell-derived microglia-like cells transplanted into rodent brains
    Fadi Jacob, Mariko L. Bennett · 2020 · Lab Animal
  30. Distinct effects of disease-associated TREM2 R47H/+ and T66M mutations on iPSC-derived microglia
    Jay Penney, William T. Ralvenius, Anjanet R. Loon, Oyku Cerit, Vishnu Dileep, Blerta Milo, Hannah Woolf, Li‐Huei Tsai · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  31. Comparative lipidomics of iPSC-derived microglia protocols reveal lipid droplet and immune differences mediated by media composition
    Aiko Robert, Amanda McQuade, Sascha Koppes-den Hertog, Lena Erlebach, Deborah Kronenberg‐Versteeg, Martin Kampmann, Martin A. Giera, Rik van der Kant · 2026 · Stem Cell Reports
  32. Alzheimer’s Disease from Modeling to Mechanism Research
    Xiaoyan Sun, Weiqi Zhang · 2024 · Advances in neurobiology
  33. Microglial exosomes: taking messaging to new spheres
    Deborah Kronenberg‐Versteeg, Balazs Viktor Varga · 2021 · Brain Communications
  34. Guía de recursos para los refugiados en España
    María Pilar Colchero, Juan Carmelo García Cabrera · 1995 · Dialnet (Universidad de la Rioja)
  35. Elevated α-synuclein attenuates phagocytosis in SNCA triplication human iPSC-derived neuron:microglia co-cultures
    Richard Lieberman, Khaled Elnaggar, Kimberly Jesseman, Sarah DeFrancisco, Kelsey L. DeGouveia, Emma G. Suneby, Hao Wu, Luis Alejandro Rojas, John D. Graef · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  36. The microglia receptor protein TREM2 is essential for protective innate immune responses against herpesvirus infection in the brain
    Stefanie Fruhwürth, Line Sinnathamby Reinert, Carl Öberg, Marcelina Sakr, Marcus Henricsson, Henrik Zetterberg, Søren R. Paludan · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  37. C9orf72 repeat expansion-carrying iPSC-microglia from FTD patients show increased phagocytic activity concomitantly with decreased number of autophagosomal-lysosomal vesicles
    Hannah Rostalski, Tomi Hietanen, Dorit B. Hoffmann, Sami Heikkinen, Nadine Huber, Ashutosh Dhingra, Salvador Rodrı́guez-Nieto, Teemu Kuulasmaa, Sohvi Ohtonen, Henna Jäntti et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  38. Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis
    Oliver Jonathan Ziff, Sarah Jolly, Jackie M. Casey, Lucy Granat, Satinder K. Samra, Núria Setó‐Salvia, Argyro Alatza, Leela Phadke, Benjamin Galet, Philippe Ravassard et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  39. Exploring Cellular Heterogeneity: Single-Cell and Spatial Transcriptomics of Alzheimer Disease Brains and iPSC-Derived Microglia
    Anjali Garg, Sheeny Vo, Logan Brase, Ekaterina Aladyeva, Ricardo D’Oliveira Albanus, Aasritha Nallapu, Hongjun Fu, Oscar Harari · 2024 · Research Square
  40. Presenilin 1 E280A mutation induces dysfunctional astrocytic phenotype in menstrual stromal-derived astrocyte-like cells
    Natalia Quiroz Correa, Miguel Mendivil‐Perez, Carlos Velez‐Pardo, Marlene Jiménez-Del-Río, Q. Quiroz-Correa · 2025 · Cellular and Molecular Life Sciences
  41. Dissecting microglial contributions to neurodegenerative disease pathophysiology using human pluripotent stem cells
    Dayoung Kim, Takayuki Kondo, Haruhisa Inoue · 2026 · Stem Cell Reports
  42. Induced pluripotent stem cell derived from postmortem tissue in neurodegenerative disease research
    Joseph Rogers, Amanda Myers, Derek M. Dykxhoorn · 2021 · Elsevier eBooks
  43. TREM2 impacts brain microglia, oligodendrocytes and endothelial co-expression modules revealing genes and pathways important in Alzheimer’s disease
    Guillermo Carbajosa, Karim Malki, Nathan Lawless, Hong Wang, John W. Ryder, Eva Wozniak, Kristie Wood, Charles A. Mein, Alan Hodgkinson, Richard Dobson et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  44. Acute IL-6 exposure triggers canonical IL-6R signalling in hiPSC microglia, but not neural progenitor cells
    Amalie C. M. Couch, Shiden Solomon, Alessia Marrocu, Rodrigo R. R. Duarte, Yiqing Sun, Laura Sichlinger, Rugilė Matulevičiūtė, Lucia Dutan Polit, Bjørn Hanger, Shahram Y. Kordasti et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  45. Amelioration of signalling deficits underlying metabolic shortfall in TREM2 R47H human iPSC-derived microglia
    Foteini Vasilopoulou, Thomas M. Piers, Jingzhang Wei, John Hardy, Jennifer M. Pocock · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  46. Impact of iPSC-derived microglial exosomes on neurons: Role of TREM2 and implication in Alzheimer's Disease
    Foteini Vasilopoulou, Ümran Yaman, Dervis A. M. Salih, John Hardy, Selina Wray, Jennifer M. Pocock · 2025 · Research Square
  47. The SNCA A53T mutation sensitizes human neurons and microglia to ferroptosis
    Laura Mahoney‐Sanchez, Hannah Clarke, Alexis Penverne, James R. Evans, Karishma D’Sa, Stephanie Strohbuecker, Patricia Lopez-Garcia, Katharina Cosker, Darija Šoltić, Benjamin O’Callaghan et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  48. Faculty Opinions recommendation of A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia.
    Dan Rujescu, Matthias Jung · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  49. Glucocorticoid receptor activation during human microglial differentiation leads to genomic instability and senescence
    Jingzhang Wei, Charles Arber, Selina Wray, John Hardy, Thomas M. Piers, Jennifer M. Pocock · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  50. Fibrinogen signalling in human iPSC-derived microglia
    Katharina Cosker, Emily Boorman, Foteini Vasilopoulou, Anna Mallach, Thomas M. Piers, Jennifer M. Pocock · 2024 · Research Square
  51. Neuroinflammation-microglia and neurodegeneration
    Aya M. Fathy, Doaa M. Mostafa, Hanan T. Sedeq, Habiba A. Hassan, Habiba W. Abdullah, Mennatullah M. Fawzy, Majdeldin E. Abdelgilil, Youssef A. Ebrahim, Wael Mohamed El-Sayed · 2024 · Elsevier eBooks
  52. HIV Protein TAT Dysregulates Multiple Pathways in Human iPSCs-Derived Microglia
    Liam Guo, Robert Jiang, Yan Cheng, Brooke Russell, Yan Y. Sanders, Ming‐Lei Guo · 2025 · Life
  53. Impact Induces Phagocytic Defect in Reactive Microglia
    Ruilin Yu, Edmond A. Rogers, Palak Manchanda, Connor H. Beveridge, Caitlin E. Randolph, Timothy Beauclair, Krupal P. Jethava, Riyi Shi, Gaurav Chopra · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  54. Modeling Alzheimer’s Disease with APOE4 Neuron-Glial Brain Assembloids Reveals IGFBPs as Therapeutic Targets
    Eliana Sherman, Kevin Qiu, Rebecca Roberts, Lucille Shichman, Sihan Li, Huayu Sun, Lucie Ide, Allison Tucker, Seonjoo Lee, Weronika Gniadzik et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  55. Additional file 2 of Human Huntington’s disease pluripotent stem cell-derived microglia develop normally but are abnormally hyper-reactive and release elevated levels of reactive oxygen species
    Grace C. O’Regan, Sahar H. Farag, Caroline S. Casey, Alison Wood‐Kaczmar, Jennifer M. Pocock, Sarah J. Tabrizi, Ralph André · 2021 · Figshare
  56. Additional file 1 of Human Huntington’s disease pluripotent stem cell-derived microglia develop normally but are abnormally hyper-reactive and release elevated levels of reactive oxygen species
    Grace C. O’Regan, Sahar H. Farag, Caroline S. Casey, Alison Wood‐Kaczmar, Jennifer M. Pocock, Sarah J. Tabrizi, Ralph André · 2021 · Figshare
  57. Mutant ATXN1 impacts human and mouse microglia and contributes to cognitive, mood, and motor deficits in SCA1 mice
    Adem Selimovic, Gourango Talukdar, Gavin J. Fuchs, Vamika Sharma, Khadija N Abbas, Sriyan C Reddy, Eshaan Parnerkar, Ian M. Brooks, Ying Zhang, Michael D. Koob et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  58. How Glial Cell Dysfunction Fuels Neurodegeneration in Alzheimer’s and Prion Diseases? Emerging Targets for Therapy
    Saima Zafar, Urwah Rasheed, Inga Zerr · 2026 · IntechOpen eBooks
  59. Uncovering the biological mechanisms of TREM2 with molecular simulations: A comprehensive review and perspective
    Emma E Lietzke, David Saeb, Emma C Aldrich, Rafael Ferreira de Menezes, Kimberley D. Bruce, Kayla G. Sprenger · 2026 · Progress in Biophysics and Molecular Biology
  60. ARID5A RNA-binding coordinates microglial defense and ferroptosis in iPSC-derived models
    Danielle M. Schafer, Steven M. Blue, Shuhao Xu, Orel Mizrahi, Maya L. Gosztyla, Lena Street, Katherine L. Rothamel, Hema Kopalle, Samuel B. Landry, Elijah K.F. Rosales et al. · 2026 · Nature Communications
  61. From Amyloid Exposure to Genetic Causality: Converging hiPSC-Based Models of Alzheimer’s Disease
    Fiorella Colasuonno, Alessio Valenza, Federica Rossin, Sandra Moreno · 2026 · Cells
  62. Dynamic remodeling of microglial responses in Alzheimer’s disease: heterogeneous states, spatiotemporal progression, and immunometabolic dysregulation
    Simin Han, Shanshan Wang, Jingjing Liu, Xulin Liu, Qinglu Wang, Chang Meng · 2026 · Frontiers in Cell and Developmental Biology