Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis
Garcia-Reitboeck, Pablo, Phillips, Alexandra, Piers, Thomas M., Villegas-Llerena, Claudio, Butler, Matt, Mallach, Anna, Rodrigues, Celia, Arber, Charles E. +7 more·2018·Cell Reports
Cited by (162)
Items 101–162 of 162
- Differential LRRK2 Signalling and Gene Expression in WT-LRRK2 and G2019S-LRRK2 Mouse Microglia Treated with Zymosan and MLi2Iqra Nazish, Adamantios Mamais, Anna Mallach, Conceição Bettencourt, Alice Kaganovich, Thomas T. Warner, John Hardy, Patrick Alfryn Lewis, Jennifer M. Pocock, Mark Cookson et al. · 2023 · Cells
- Emerging Models to Study Human Microglia In vitroHenna Jäntti, Lois Kistemaker, Alice Buonfiglioli, Lot D. de Witte, Tarja Malm, Elly M. Hol · 2024 · Advances in neurobiology
- Exploring cellular heterogeneity: single-cell and spatial transcriptomics of Alzheimer's disease brains and iPSC-derived microgliaAnjali Garg, Sheeny Vo, Iara Dantas de Souza, Ayslan Castro Brant, Logan Brase, Ekaterina Aladyeva, Ricardo D’Oliveira Albanus, Aasritha Nallapu, Hongjun Fu, Oscar Harari · 2025 · Alzheimer s Research & Therapy
- Human-Induced Pluripotent Stem Cell–Based Models for Studying Sex-Specific Differences in Neurodegenerative DiseasesErkan Kiris · 2021 · Advances in experimental medicine and biology
- The role of triggering receptor expressed on myeloid cells 2 in Parkinson’s disease and other neurodegenerative disordersHannah Schwarz, Sarah Bässler, Denise Balta, Eileen Socher, Friederike Zunke, Philipp Arnold · 2022 · Behavioural Brain Research
- In vitro Quantitative Imaging Assay for Phagocytosis of Dead Neuroblastoma Cells by iPSC-MacrophagesHazel Hall‐Roberts, Elena Di Daniel, William James, John B. Davis, Sally A. Cowley · 2021 · Journal of Visualized Experiments
- In vitro Quantitative Imaging Assay for Phagocytosis of Dead Neuroblastoma Cells by iPSC-MacrophagesHazel Hall‐Roberts, Elena Di Daniel, William James, John B. Davis, Sally A. Cowley · 2021 · Journal of Visualized Experiments
- The downregulation of TREM2 exacerbates toxicity of development and neurobehavior induced by aluminum chloride and nano-alumina in adult zebrafishYing Zhang, Xinyue Guo, Jinjin Zhao, Xiaocheng Gao, Lan Zhang, Tao Huang, Yanhong Wang, Q. L. Niu, Qinli Zhang · 2024 · Toxicology and Applied Pharmacology
- Microglia contribute to the production of the amyloidogenic ABri peptide in familial British dementiaCharles Arber, Jackie M. Casey, Samuel Crawford, Naiomi Rambarack, Ümran Yaman, Sarah Wiethoff, Emma Augustin, Thomas M. Piers, Matthew Price, Agueda A. Rostagno et al. · 2024 · Acta Neuropathologica
- Lactobacillus for ribosome peptide editing cancerShousong Yue, Qiuxia He, Jean‐François Picimbon · 2023 · Clinical & Translational Oncology
- Leveraging iPSC technology to assess neuro-immune interactions in neurological and psychiatric disordersChristina Michalski, Zhexing Wen · 2023 · Frontiers in Psychiatry
- Expanding the neuroimmune research toolkit with in vivo brain organoid technologiesAi Tian, Afrin Bhattacharya, Julien Muffat, Yun Li · 2025 · Disease Models & Mechanisms
- Human myeloid progenitor glucocorticoid receptor activation causes genomic instability, type 1 IFN ‐ response pathway activation and senescence in differentiated microglia; an early life stress modelJingzhang Wei, Charles Arber, Selina Wray, John Hardy, Thomas M. Piers, Jennifer M. Pocock · 2022 · Glia
- Translational regulation and protein-coding capacity of the 5′ untranslated region of human TREM2Motoaki Yanaizu, Haruka Adachi, Makoto Araki, Kenji Kontani, Yoshihiro Kino · 2023 · Communications Biology
- microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer’s disease patientsPenning, Amber, Snoeck, Sarah, Ormaechea, Olmo Ruiz, Ayyildiz, Dilara, Polzer, Oliver, Buitrago-Arango, Martin, Capobianco, Raffaella, de Winter, Fred, Balusu, Sriram, Verhaagen, Joost et al. · 2026 · Acta Neuropathologica Communications
- Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysisOliver Jonathan Ziff, Sarah Jolly, Jackie M. Casey, Lucy Granat, Satinder Samra, Núria Setó‐Salvia, Argyro Alatza, Leela Phadke, Benjamin Galet, Philippe Ravassard et al. · 2025 · Molecular Neurodegeneration
- Microglial Drivers of Alzheimer's Disease Pathology: An Evolution of Diverse Participating StatesMadison K. Kuhn, Elizabeth A. Proctor · 2024 · Proteins Structure Function and Bioinformatics
- TSPO PET Imaging as a Biomarker of Neuroinflammation in Neurodegenerative DisordersEryn L. Werry, Fiona Bright, Michael Kassiou · 2021 · Neuromethods
- Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson’s diseaseJames R. Evans, Melissa Grant‐Peters, Joseph S. Beckwith, Christina E. Toomey, Rebeka Popovic, Jonathan C. Breiter, Jonathan Brenton, Aine Fairbrother-Browne, Stephanie Strohbuecker, Joanne Lachica et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- First-in-class SAM-competitive G9a inhibitor FLAV-27 as a disease-modifying therapy for Alzheimer diseaseAina Bellver‐Sanchís, David Valle‐García, Carla Barbaraci, Fernando Romero-Becerra, Rohit Kumar Singh, Júlia Jarné‐Ferrer, Foteini Vasilopoulou, Alba Irisarri, Carmen Martínez-Fernández, Juan A. Fafián-Labora et al. · 2025 · Molecular Therapy
- A critical guideline for controlling monocyte-derived macrophages phenotypesGiorgia Moschetti, Doriana Oliveri, Valeria De Matteis, Marta Zaccaria, Diego Rondelli, Anna Griego, Edoardo Scarpa, Loris Rizzello · 2026 · Frontiers in Immunology
- Microglia Detect Externalized Phosphatidylserine on Synapses for Elimination via TREM2 in Alzheimer’s Disease ModelsJavier Rueda‐Carrasco, Dimitra Sokolova, Sang‐Eun Lee, Thomas Childs, Natália Jurčáková, Sebastiaan De Schepper, Judy Z. Ge, Joanne Lachica, Christina E. Toomey, Oliver J. Freeman et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- A scoping review of stem cell models of leukodystrophies: advances in understanding pathophysiological mechanismsAlexandra Chapleau, Stefanie Perrier, Thomas M. Durcan, Geneviève Bernard · 2025 · npj Genomic Medicine
- Tissue signatures of human macrophages during homeostasis and activationDaniel P. Caron, William L. Specht, Siddhi Nargund, David Chen, Steven B. Wells, Jennifer Hwu, Peter Anthony Szabo, Peter A. Sims, Donna L. Färber · 2025 · The Journal of Immunology
- Alterations in the brain lipidome of Alzheimer's disease donors with rare TREM2 risk variantsPetroula Proitsi, Amera Ebshiana, Asger Wretlind, Jin Xu, Angela Hodges, Cristina Legido‐Quigley · 2026 · Brain Communications
- Anatomical location of injected microglia in different activation states and time course of injury determines survival of retinal ganglion cells after optic nerve crushAhad M. Siddiqui, Thomas F. Sabljic, Alexander K. Ball · 2022 · International Journal of Neuroscience
- Advancing novel therapies for neurodegeneration through an innovative model for industry–academia collaborations: A decade of the Eisai–UCL experiencePeter J. Atkinson, Meera Swami, Nicola Ridgway, Malcolm Roberts, Jane Kinghorn, Thomas T. Warner, James M. Staddon, Andrew K. Takle · 2023 · Drug Discovery Today
- Human induced pluripotent stem cell– based modeling of Alzheimer’s disease, a glial perspectiveXianwei Chen, Qingqiu Yang, Zhenqing Liu, Yanhong Shi · 2021 · Elsevier eBooks
- Modeling neurological disease using human stem cell-derived microglia-like cells transplanted into rodent brainsFadi Jacob, Mariko L. Bennett · 2020 · Lab Animal
- Distinct effects of disease-associated TREM2 R47H/+ and T66M mutations on iPSC-derived microgliaJay Penney, William T. Ralvenius, Anjanet R. Loon, Oyku Cerit, Vishnu Dileep, Blerta Milo, Hannah Woolf, Li‐Huei Tsai · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Comparative lipidomics of iPSC-derived microglia protocols reveal lipid droplet and immune differences mediated by media compositionAiko Robert, Amanda McQuade, Sascha Koppes-den Hertog, Lena Erlebach, Deborah Kronenberg‐Versteeg, Martin Kampmann, Martin A. Giera, Rik van der Kant · 2026 · Stem Cell Reports
- Alzheimer’s Disease from Modeling to Mechanism ResearchXiaoyan Sun, Weiqi Zhang · 2024 · Advances in neurobiology
- Microglial exosomes: taking messaging to new spheresDeborah Kronenberg‐Versteeg, Balazs Viktor Varga · 2021 · Brain Communications
- Guía de recursos para los refugiados en EspañaMaría Pilar Colchero, Juan Carmelo García Cabrera · 1995 · Dialnet (Universidad de la Rioja)
- Elevated α-synuclein attenuates phagocytosis in SNCA triplication human iPSC-derived neuron:microglia co-culturesRichard Lieberman, Khaled Elnaggar, Kimberly Jesseman, Sarah DeFrancisco, Kelsey L. DeGouveia, Emma G. Suneby, Hao Wu, Luis Alejandro Rojas, John D. Graef · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- The microglia receptor protein TREM2 is essential for protective innate immune responses against herpesvirus infection in the brainStefanie Fruhwürth, Line Sinnathamby Reinert, Carl Öberg, Marcelina Sakr, Marcus Henricsson, Henrik Zetterberg, Søren R. Paludan · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- C9orf72 repeat expansion-carrying iPSC-microglia from FTD patients show increased phagocytic activity concomitantly with decreased number of autophagosomal-lysosomal vesiclesHannah Rostalski, Tomi Hietanen, Dorit B. Hoffmann, Sami Heikkinen, Nadine Huber, Ashutosh Dhingra, Salvador Rodrı́guez-Nieto, Teemu Kuulasmaa, Sohvi Ohtonen, Henna Jäntti et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysisOliver Jonathan Ziff, Sarah Jolly, Jackie M. Casey, Lucy Granat, Satinder K. Samra, Núria Setó‐Salvia, Argyro Alatza, Leela Phadke, Benjamin Galet, Philippe Ravassard et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Exploring Cellular Heterogeneity: Single-Cell and Spatial Transcriptomics of Alzheimer Disease Brains and iPSC-Derived MicrogliaAnjali Garg, Sheeny Vo, Logan Brase, Ekaterina Aladyeva, Ricardo D’Oliveira Albanus, Aasritha Nallapu, Hongjun Fu, Oscar Harari · 2024 · Research Square
- Presenilin 1 E280A mutation induces dysfunctional astrocytic phenotype in menstrual stromal-derived astrocyte-like cellsNatalia Quiroz Correa, Miguel Mendivil‐Perez, Carlos Velez‐Pardo, Marlene Jiménez-Del-Río, Q. Quiroz-Correa · 2025 · Cellular and Molecular Life Sciences
- Dissecting microglial contributions to neurodegenerative disease pathophysiology using human pluripotent stem cellsDayoung Kim, Takayuki Kondo, Haruhisa Inoue · 2026 · Stem Cell Reports
- Induced pluripotent stem cell derived from postmortem tissue in neurodegenerative disease researchJoseph Rogers, Amanda Myers, Derek M. Dykxhoorn · 2021 · Elsevier eBooks
- TREM2 impacts brain microglia, oligodendrocytes and endothelial co-expression modules revealing genes and pathways important in Alzheimer’s diseaseGuillermo Carbajosa, Karim Malki, Nathan Lawless, Hong Wang, John W. Ryder, Eva Wozniak, Kristie Wood, Charles A. Mein, Alan Hodgkinson, Richard Dobson et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Acute IL-6 exposure triggers canonical IL-6R signalling in hiPSC microglia, but not neural progenitor cellsAmalie C. M. Couch, Shiden Solomon, Alessia Marrocu, Rodrigo R. R. Duarte, Yiqing Sun, Laura Sichlinger, Rugilė Matulevičiūtė, Lucia Dutan Polit, Bjørn Hanger, Shahram Y. Kordasti et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Amelioration of signalling deficits underlying metabolic shortfall in TREM2 R47H human iPSC-derived microgliaFoteini Vasilopoulou, Thomas M. Piers, Jingzhang Wei, John Hardy, Jennifer M. Pocock · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Impact of iPSC-derived microglial exosomes on neurons: Role of TREM2 and implication in Alzheimer's DiseaseFoteini Vasilopoulou, Ümran Yaman, Dervis A. M. Salih, John Hardy, Selina Wray, Jennifer M. Pocock · 2025 · Research Square
- The SNCA A53T mutation sensitizes human neurons and microglia to ferroptosisLaura Mahoney‐Sanchez, Hannah Clarke, Alexis Penverne, James R. Evans, Karishma D’Sa, Stephanie Strohbuecker, Patricia Lopez-Garcia, Katharina Cosker, Darija Šoltić, Benjamin O’Callaghan et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Faculty Opinions recommendation of A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia.Dan Rujescu, Matthias Jung · 2020 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Glucocorticoid receptor activation during human microglial differentiation leads to genomic instability and senescenceJingzhang Wei, Charles Arber, Selina Wray, John Hardy, Thomas M. Piers, Jennifer M. Pocock · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Fibrinogen signalling in human iPSC-derived microgliaKatharina Cosker, Emily Boorman, Foteini Vasilopoulou, Anna Mallach, Thomas M. Piers, Jennifer M. Pocock · 2024 · Research Square
- Neuroinflammation-microglia and neurodegenerationAya M. Fathy, Doaa M. Mostafa, Hanan T. Sedeq, Habiba A. Hassan, Habiba W. Abdullah, Mennatullah M. Fawzy, Majdeldin E. Abdelgilil, Youssef A. Ebrahim, Wael Mohamed El-Sayed · 2024 · Elsevier eBooks
- HIV Protein TAT Dysregulates Multiple Pathways in Human iPSCs-Derived MicrogliaLiam Guo, Robert Jiang, Yan Cheng, Brooke Russell, Yan Y. Sanders, Ming‐Lei Guo · 2025 · Life
- Impact Induces Phagocytic Defect in Reactive MicrogliaRuilin Yu, Edmond A. Rogers, Palak Manchanda, Connor H. Beveridge, Caitlin E. Randolph, Timothy Beauclair, Krupal P. Jethava, Riyi Shi, Gaurav Chopra · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Modeling Alzheimer’s Disease with APOE4 Neuron-Glial Brain Assembloids Reveals IGFBPs as Therapeutic TargetsEliana Sherman, Kevin Qiu, Rebecca Roberts, Lucille Shichman, Sihan Li, Huayu Sun, Lucie Ide, Allison Tucker, Seonjoo Lee, Weronika Gniadzik et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Additional file 2 of Human Huntington’s disease pluripotent stem cell-derived microglia develop normally but are abnormally hyper-reactive and release elevated levels of reactive oxygen speciesGrace C. O’Regan, Sahar H. Farag, Caroline S. Casey, Alison Wood‐Kaczmar, Jennifer M. Pocock, Sarah J. Tabrizi, Ralph André · 2021 · Figshare
- Additional file 1 of Human Huntington’s disease pluripotent stem cell-derived microglia develop normally but are abnormally hyper-reactive and release elevated levels of reactive oxygen speciesGrace C. O’Regan, Sahar H. Farag, Caroline S. Casey, Alison Wood‐Kaczmar, Jennifer M. Pocock, Sarah J. Tabrizi, Ralph André · 2021 · Figshare
- Mutant ATXN1 impacts human and mouse microglia and contributes to cognitive, mood, and motor deficits in SCA1 miceAdem Selimovic, Gourango Talukdar, Gavin J. Fuchs, Vamika Sharma, Khadija N Abbas, Sriyan C Reddy, Eshaan Parnerkar, Ian M. Brooks, Ying Zhang, Michael D. Koob et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- How Glial Cell Dysfunction Fuels Neurodegeneration in Alzheimer’s and Prion Diseases? Emerging Targets for TherapySaima Zafar, Urwah Rasheed, Inga Zerr · 2026 · IntechOpen eBooks
- Uncovering the biological mechanisms of TREM2 with molecular simulations: A comprehensive review and perspectiveEmma E Lietzke, David Saeb, Emma C Aldrich, Rafael Ferreira de Menezes, Kimberley D. Bruce, Kayla G. Sprenger · 2026 · Progress in Biophysics and Molecular Biology
- ARID5A RNA-binding coordinates microglial defense and ferroptosis in iPSC-derived modelsDanielle M. Schafer, Steven M. Blue, Shuhao Xu, Orel Mizrahi, Maya L. Gosztyla, Lena Street, Katherine L. Rothamel, Hema Kopalle, Samuel B. Landry, Elijah K.F. Rosales et al. · 2026 · Nature Communications
- From Amyloid Exposure to Genetic Causality: Converging hiPSC-Based Models of Alzheimer’s DiseaseFiorella Colasuonno, Alessio Valenza, Federica Rossin, Sandra Moreno · 2026 · Cells
- Dynamic remodeling of microglial responses in Alzheimer’s disease: heterogeneous states, spatiotemporal progression, and immunometabolic dysregulationSimin Han, Shanshan Wang, Jingjing Liu, Xulin Liu, Qinglu Wang, Chang Meng · 2026 · Frontiers in Cell and Developmental Biology