Single-cell RNA-seq uncovers a robust transcriptional response to morphine by glia

Avey, Denis, Sankararaman, Sumithra, Yim, Aldrin K.Y., Barve, Ruteja, Milbrandt, Jeffrey, Mitra, Robi D.·2018·Cell Reports

Cited by (147)

Items 101–147 of 147

  1. How omics is revealing new roles for glia in addiction
    David J. Bergkamp, John F. Neumaier · 2024 · Glia
  2. Single-nucleus RNA-sequencing of orbitofrontal cortex in rat model of methamphetamine-induced sensitization
    Qiong Li, Zhi-Peng Yu, Yan-Guo Li, Zi-Hang Tang, Yongfeng Hu, Majie Wang, Haowei Shen · 2024 · Neuroscience Letters
  3. RiboTag-Seq Reveals a Compensatory cAMP Responsive Gene Network in Striatal Microglia Induced by Morphine Withdrawal
    Kevin R. Coffey, Atom J. Lesiak, Russell G. Marx, Emily K. Vo, Gwenn A. Garden, John F. Neumaier · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  4. Inhibition of RtTg neurons reverses methamphetamine-induced attention deficits
    Xiaotian Qu, Pingyuan Yang, Rongwei Zhai, Zhi‐Qi Xiong · 2024 · Acta Neuropathologica Communications
  5. The actions of morphine on microglia and the underlying effects on associated adverse effects
    Weihua Wu, Qian Li, Fei Yang · 2025 · Psychopharmacology
  6. Transcriptional Response to Chronic Long‐Access Fentanyl Self‐Administration in Rat Habenula and Amygdala
    Robin Magnard, Daianna González‐Padilla, Ege A Yalcinbas, Emma Chaloux-Pinette, Nicholas J. Eagles, Michael S. Totty, Patricia H. Janak, Leonardo Collado‐Torres, Kristen R. Maynard · 2026 · Addiction Biology
  7. TLR4 TIR domain and nucleolin GAR domain synergistically mediate RSV infection and induce neuronal inflammatory damage in SH‐SY5Y cells
    Chengcheng Jiang, Yixuan Huang, Hongya Gui, Xiaojie Liu, Haiwen Li, Maozhen Han, Shenghai Huang · 2024 · Journal of Medical Virology
  8. Transcriptomic profiling of mouse amygdala during opioid dependence and withdrawal by single-cell RNA sequencing
    Yan Yan, Bridget Truitt, Sean Michael Boyles, Junyi Tao, William F. Hulme, Sabita Roy · 2022 · Research Square
  9. Cocaine addiction-like behaviors are associated with long-term changes in gene regulation, energy metabolism, and GABAergic inhibition within the amygdala
    Jessica Zhou, Giordano de Guglielmo, Aaron J. Ho, Marsida Kallupi, Narayan Prasad Pokhrel, Hairi Li, Apurva S. Chitre, Daniel B. Munro, Pejman Mohammadi, Lieselot L. G. Carrette et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  10. Reelin marks cocaine-activated striatal ensembles, promotes neuronal excitability, and regulates cocaine reward
    Kasey L. Brida, Emily T. Jorgensen, Robert A. Phillips, Catherine E. Newman, Jennifer J. Tuscher, Emily K. Morring, Morgan E. Zipperly, Lara Ianov, Kelsey D. Montgomery, Madhavi Tippani et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  11. Sex-divergent brain epigenetic reprogramming by chronic opioids
    Camille Falconnier, Alba Caparros-Roissard, Hanuš Slavík, Mithil Gaikwad, Victor Mathis, Margot Diringer, Charles Decraene, Salim Megat, Sebahat Ozkan, Mohamad Yassine et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  12. Single cell RNA transcriptome response to fentanyl use in persons with hepatitis C virus infection
    Krishna M. Roskin, Heidi L. Meeds, Janani Madhuravasal Krishnan, Matthew P. Juhascik, John M. Cafardi, Jennifer L. Brown, Caroline E. Freiermuth, Michael S. Lyons, Kenneth E. Sherman, Jason T. Blackard · 2025 · Frontiers in Virology
  13. Single cell RNA transcriptome response to fentanyl use in persons with HIV infection
    Krishna M. Roskin, Heidi L. Meeds, Janani Madhuravasal Krishnan, Matthew P. Juhascik, John M. Cafardi, Jennifer L. Brown, Caroline E. Freiermuth, Michael S. Lyons, Kenneth E. Sherman, Jason T. Blackard · 2026 · Scientific Reports
  14. Changes in Blood DNA CpG Methylation Levels in Response to Methadone Maintenance Treatment: Epigenome-Wide Longitudinal Study
    Orna Levran, Y. Kim, Justin Li, Anat Sason, Miriam Adelson, Einat Peles · 2026 · Epigenomes
  15. Integrating single-cell atlases and machine learning to construct ‘in silico patients’ for predicting individualized drug responses
    Zhuo Zuo, Yulong Sun · 2026 · Biochemical Pharmacology
  16. Finding Significant Hits in Networks: a network-based tool for analyzing gene-level P -values to identify significant genes missed by standard methods
    Sandeep Acharya, Vaha Akbary Moghaddam, Wooseok J. Jung, Yu Sung Kang, Shu Liao, Michael A. Province, Michael R. Brent · 2026 · Briefings in Bioinformatics
  17. Single-Cell Suspension Preparation from Nile Tilapia Intestine for Single-Cell Sequencing
    Peibo Wang, Yongcan Zhou, Bei Wang, Ahmed Elaswad, Shifeng Wang, Weiliang Guo, Dongdong Zhang · 2023 · Journal of Visualized Experiments
  18. FISHNET: A Network-based Tool for Analyzing Gene-level P-values to Identify Significant Genes Missed by Standard Methods
    Sandeep Acharya, Vaha Akbary Moghaddam, Wooseok J. Jung, Yu Sung Kang, Shu Liao, Michael A. Province, Michael R. Brent · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  19. A conserved population of genetically defined striatal neurons gates opioid reward
    Olivia R. Drake, Caroline M. Fiore, Emily T. Jorgensen, Catherine E. Newman, Luke Potter, Austyn Trull, Aditya Pradeep, Lara Ianov, Jamie Peters, Jasper A. Heinsbroek et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  20. Cortical Stroke Produces Secondary Injury and Long-lasting Gliosis in the Ipsilateral Thalamus
    Gab Seok Kim, Jessica M. Stephenson, Abdullah Al Mamun, Ting Wu, Monica G. Goss, Jia‐Wei Min, Jun Li, Fudong Liu, Sean P. Marrelli · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  21. The Role of Microglial-Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) in Neuronal Homeostasis and Tau Pathogenesis
    Vaishnavi Jadhav · 2021 · IUScholarWorks (Indiana University)
  22. 梨园戏《梁灏》渊源考述——兼与莆仙戏《梁灏》比较
    杨榕 · 2012 · 福建艺术
  23. Molecular Consequences of Peripheral Influenza A Infection on Cell Populations in the Murine Hypothalamus
    René Lemcke, Christine Egebjerg, Nicolai T. Berendtsen, Kristoffer Lihme Egerod, Allan Randrup Thomsen, Tune H. Pers, Jan Pravsgaard Christensen, Birgitte Rahbek Kornum · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  24. Reviewer #2 (Public Review): Molecular Consequences of Peripheral Influenza A Infection on Cell Populations in the Murine Hypothalamus
    Lemcke René, Egebjerg Christine, Berendtsen Nicolai T. · 2023 · eLife
  25. Reviewer #1 (Public Review): Molecular Consequences of Peripheral Influenza A Infection on Cell Populations in the Murine Hypothalamus
    René Lemcke, Christine Egebjerg, Nicolai T. Berendtsen · 2023 · eLife
  26. eLife Assessment: Molecular Consequences of Peripheral Influenza A Infection on Cell Populations in the Murine Hypothalamus
    Mauricio Comas‐García · 2023 · eLife
  27. Molecular Consequences of Peripheral Influenza A Infection on Cell Populations in the Murine Hypothalamus
    René Lemcke, Christine Egebjerg, Nicolai T. Berendtsen, Kristoffer Lihme Egerod, Allan Randrup Thomsen, Tune H. Pers, Jan Pravsgaard Christensen, Birgitte Rahbek Kornum · 2023 · eLife
  28. Molecular Consequences of Peripheral Influenza A Infection on Cell Populations in the Murine Hypothalamus
    René Lemcke, Christine Egebjerg, Nicolai T. Berendtsen, Kristoffer Lihme Egerod, Allan Randrup Thomsen, Tune H. Pers, Jan Pravsgaard Christensen, Birgitte Rahbek Kornum · 2023 · eLife
  29. Additional file 7 of Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice
    Vaishnavi Jadhav, Peter Bor‐Chian Lin, Taylor Pennington, Gonzalo Viana Di Prisco, Asha Jacob Jannu, Guixiang Xu, Miguel Moutinho, Jie Zhang, Brady K. Atwood, Shweta S. Puntambekar et al. · 2020 · Figshare
  30. Additional file 6 of Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice
    Vaishnavi Jadhav, Peter Bor‐Chian Lin, Taylor Pennington, Gonzalo Viana Di Prisco, Asha Jacob Jannu, Guixiang Xu, Miguel Moutinho, Jie Zhang, Brady K. Atwood, Shweta S. Puntambekar et al. · 2020 · Figshare
  31. Additional file 5 of Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice
    Vaishnavi Jadhav, Peter Bor‐Chian Lin, Taylor Pennington, Gonzalo Viana Di Prisco, Asha Jacob Jannu, Guixiang Xu, Miguel Moutinho, Jie Zhang, Brady K. Atwood, Shweta S. Puntambekar et al. · 2020 · Figshare
  32. Additional file 8 of Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice
    Vaishnavi Jadhav, Peter Bor‐Chian Lin, Taylor Pennington, Gonzalo Viana Di Prisco, Asha Jacob Jannu, Guixiang Xu, Miguel Moutinho, Jie Zhang, Brady K. Atwood, Shweta S. Puntambekar et al. · 2020 · Figshare
  33. Activity-Related Transcription: Role in Addiction
    Jacob S. Rounds, Dina P. Matheos, Marcelo A. Wood · 2024 · Springer eBooks
  34. VGF in the Nucleus Accumbens Regulates Synaptic and Opioid-Evoked Plasticity
    Anisha P. Adke, Lydia B Cunitz, Rachel M. Dick, Tuba H. Ali, Carmen Julia Salvatierra Rocha, Ying Zhang, Lucy Vulchanova, Patrick E. Rothwell · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  35. Age-dependent transcriptomic effects of morphine in the frontal cortex of female mice
    Jarvis Savage, Anupama Rai, Jonathan D. Lee, Jane Banahan, Kristina Dujic, Masiel Nunez, Barbara J. Caldarone, Sarbani Ghoshal, Frank John Slack, Maria Mavrikaki · 2025 · Neuropharmacology
  36. Additional file 1 of Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice
    Vaishnavi Jadhav, Peter Bor‐Chian Lin, Taylor Pennington, Gonzalo Viana Di Prisco, Asha Jacob Jannu, Guixiang Xu, Miguel Moutinho, Jie Zhang, Brady K. Atwood, Shweta S. Puntambekar et al. · 2020 · Figshare
  37. Additional file 4 of Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice
    Vaishnavi Jadhav, Peter Bor‐Chian Lin, Taylor Pennington, Gonzalo Viana Di Prisco, Asha Jacob Jannu, Guixiang Xu, Miguel Moutinho, Jie Zhang, Brady K. Atwood, Shweta S. Puntambekar et al. · 2020 · Figshare
  38. Additional file 10 of Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice
    Vaishnavi Jadhav, Peter Bor‐Chian Lin, Taylor Pennington, Gonzalo Viana Di Prisco, Asha Jacob Jannu, Guixiang Xu, Miguel Moutinho, Jie Zhang, Brady K. Atwood, Shweta S. Puntambekar et al. · 2020 · Figshare
  39. Additional file 11 of Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice
    Vaishnavi Jadhav, Peter Bor‐Chian Lin, Taylor Pennington, Gonzalo Viana Di Prisco, Asha Jacob Jannu, Guixiang Xu, Miguel Moutinho, Jie Zhang, Brady K. Atwood, Shweta S. Puntambekar et al. · 2020 · Figshare
  40. Additional file 3 of Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice
    Vaishnavi Jadhav, Peter Bor‐Chian Lin, Taylor Pennington, Gonzalo Viana Di Prisco, Asha Jacob Jannu, Guixiang Xu, Miguel Moutinho, Jie Zhang, Brady K. Atwood, Shweta S. Puntambekar et al. · 2020 · Figshare
  41. Additional file 2 of Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice
    Vaishnavi Jadhav, Peter Bor‐Chian Lin, Taylor Pennington, Gonzalo Viana Di Prisco, Asha Jacob Jannu, Guixiang Xu, Miguel Moutinho, Jie Zhang, Brady K. Atwood, Shweta S. Puntambekar et al. · 2020 · Figshare
  42. Additional file 9 of Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice
    Vaishnavi Jadhav, Peter Bor‐Chian Lin, Taylor Pennington, Gonzalo Viana Di Prisco, Asha Jacob Jannu, Guixiang Xu, Miguel Moutinho, Jie Zhang, Brady K. Atwood, Shweta S. Puntambekar et al. · 2020 · Figshare
  43. Not just neurons: glial mechanisms driving sex-specific vulnerability to withdrawal and relapse in substance use disorder
    Nicole L. Horan, Tori Keefauver, Marianne L. Seney · 2026 · Frontiers in Neuroendocrinology
  44. Fentanyl‐Induced Changes in the Cellular Transcriptome of a Person Living With HIV: A Case Report
    Krishna M. Roskin, Heidi L. Meeds, Janani Madhuravasal Krishnan, Matthew P. Juhascik, John M. Cafardi, Jennifer L. Brown, Caroline E. Freiermuth, Michael S. Lyons, Kenneth E. Sherman, Jason T. Blackard · 2026 · Case Reports in Infectious Diseases
  45. Genome-wide link between DNA replication and genome instability at the single cell level
    Joseph M. Josephides · 2023
  46. Sex differences in functional genomic mechanisms of opioid action
    Camille Falconnier · 2023 · theses.fr (ABES)
  47. Spatial transcriptomics reveals distinct cell type dynamics following opioid dependence in female mice with the common human μ-opioid receptor variant Oprm1 A118G
    Yihan Xie, Anna K. Leonard, Omar Guessoum, Kyle A. Windisch, Johnathan Schug, Hilana El‐Mekkoussi, Adrienne Y. Jo, D. Kacy Cullen, Klaus H. Kaestner, Julie A. Blendy · 2026 · Nature Communications