Upregulation of the Autophagy Adaptor p62/SQSTM1 Prolongs Health and Lifespan in Middle-Aged Drosophila
Aparicio, Ricardo, Rana, Anil, Walker, David W.·2019·Cell Reports
Cited by (129)
Items 101–129 of 129
- Transcriptional Dysregulation of Autophagy in Aging and Potential Interventions: Insights Into TFEB and FOXOsCheng‐Ju Kuo, Denisa Mihaela Manastireanu, José L. Nieto-Torres, Caroline Kumsta · 2025 · Frontiers in Bioscience-Landmark
- Mitochondrion-targeted magnolol derivatives exert synergistic anticancer activity by modulating energy metabolism and tumor microenvironmentYing Wang, Jie Zhang, Yehong Tan, Siran Jiang, Meiyi Tong, Xiaoyong Wang · 2025 · European Journal of Medicinal Chemistry
- Analysis of the transcriptional pathways associated with the induction of quiescent embryonic arrest in the calanoid copepod Acartia tonsaM. Cifuentes, Benni Winding Hansen, Tue Sparholt Jørgensen, Louise T. Dalgaard · 2023 · Developmental Biology
- Autophagy is dispensable in germline stem cells but is required in the cap cells for their maintenance in the Drosophila ovarian nicheKiran Suhas Nilangekar, Bhupendra V. Shravage · 2025 · Stem Cell Reports
- Analysis of Mitochondrial Dynamics in AdultDrosophilaAxonsDaniel C. Maddison, Francesca Mattedi, Alessio Vagnoni, Gaynor Ann Smith · 2022 · Cold Spring Harbor Protocols
- Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin modelsAitor Martinez, Álvaro Sánchez-Martínez, Jake T. Pickering, Madeleine J. Twyning, Ana Terriente-Félix, Po‐Lin Chen, Chun‐Hong Chen, Alexander J. Whitworth · 2023 · Research Square
- FAM162A is Crucial for Mitochondrial Structure, Dynamics, and Bioenergetics, Driving Cellular Protection and LongevityAndrea Matamoros, Juan Pablo Soffia, M.H. Munoz, Michael Maturana Quiñones, Alvaro M. Gonzalez-Ibañez, Gabriela Gómez-Lillo, César Astorga, Lina María Ruíz, Ramón A. Jorquera, Álvaro A. Elorza · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Elevated mitochondrial superoxide promotes longevity through a mitochondria-to-nucleus kinase signaling pathwayUlrich Anglas, Aura A Tamez González, Maisha Maliha Promi, Shusen Zhu, Abdelrahman AlOkda, Alain Pacis, Vincent R. Richard, Christoph H. Borchers, Jeremy M. Van Raamsdonk · 2026 · Redox Biology
- Electric-field induced sleep promotion and lifespan extension in Gaucher's disease model fliesTakaki Nedachi, Haruhisa Kawasaki, Eiji Inoue, Takahiro Suzuki, Yuzo Nakagawa-Yagi, Norio Ishida · 2025 · Biochemistry and Biophysics Reports
- Autophagy slows the aging of Germline stem cells in Drosophila through modulation of E-cadherinNidhi Murmu, Bhupendra V. Shravage · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
- Proximity labeling reveals dynamic changes in the SQSTM1 protein networkAlejandro Nico Rondón-Ortiz, Lushuang Zhang, Peter E.A. Ash, Avik Basu, Sambhavi Puri, Sophie J. F. van der Spek, Zihan Wang, Luke Dorrian, Andrew Emili, Benjamin L. Wolozin · 2024 · Journal of Biological Chemistry
- Identification, Expression of AaSQSTM1 in Aedes albopictus and Its Autophagic Function AnalysisHaodong Xu, Yijia Huang, Zihan Liang, Xiao Feng, Nan Wang, Haojie Wang, Sheng Gao, Hongbo Li, Wen-Quan Liu, Shaohui Liang · 2025 · Insects
- FAM162A Is a Key Regulator of Mitochondrial Structure, Dynamics, and Bioenergetics, Driving Cellular Protection and LongevityAndrea Matamoros, Juan Pablo Soffia, M.H. Munoz, Michael Maturana, Ma. Andreina Rangel-Ramírez, Alvaro M. Gonzalez-Ibañez, Gabriela Gómez-Lillo, César Astorga, Lina María Ruíz, Ramón A. Jorquera et al. · 2026 · Aging Cell
- Antioxidant mechanism of modified Qiongyu paste against aging based on network pharmacology and experimental validationTianshu Xie, Qi Ding, Siwen Feng, Zimin Liu, Yuanyuan Shi · 2022 · Journal of Traditional Chinese Medical Sciences
- Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin modelsAitor Martinez, Álvaro Sánchez-Martínez, Jake T. Pickering, Madeleine J. Twyning, Ana Terriente-Félix, Po‐Lin Chen, Chun‐Hong Chen, Alexander J. Whitworth · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Ruimte voor tieners. : Eindadvies commissie TieneropvangJan A.R. Heemskerk, Zeki Arslan, Gerda E.M. Bosdriesz, Edit Hallensleben, Jan Laurens Hazekamp, Monique C. van Leeuwen, Janneke Plantenga, te tePoel, Roel Schrotenboer, Mariëtte H.A. Crasborn · 2002
- Potencial terapêutico das células-tronco mesenquimais na doença renal diabética é mediado pelo efeito antioxidante e modulador no programa de controle de qualidade mitocondrialChristian Silva · 2020
- Gene identification and RNAi-silencing of p62/SQSTM1 in the vector Rhodnius prolixus reveals a high degree of sequence conservation but no apparent deficiency-related phenotypes in vitellogenic femalesJéssica Pereira, Samara Santos‐Araújo, Larissa Bomfim, Kátia C. Gondim, David Majerowicz, Attilio Pane, Isabela Ramos · 2023 · PLoS ONE
- Electric-Field Induced Sleep Promotion and Lifespan Extension in Gaucher's Disease Model Flies: Association with Improving Er Stress and AutophagyTakaki Nedachi, Haruhisa Kawasaki, Eiji Inoue, Takahiro Suzuki, Yuzo Nakagawa-Yagi, Norio Ishida · 2024 · SSRN Electronic Journal
- Electric-Field Induced Sleep Promotion and Lifespan Extension in Gaucher's Disease Model Flies: Association with Improving Endoplasmic Reticulum Stress and AutophagyTakaki Nedachi, Haruhisa Kawasaki, Eiji Inoue, Takahiro Suzuki, Yuzo Nakagawa-Yagi, Norio Ishida · 2024 · SSRN Electronic Journal
- Synthesis and Biological Evaluation of Novel Triazine Analogs as Rad6 InhibitorsQian Lin, Ambikai Gajan, Ignatius Nguyen, Shiv Kumar Sharma, Pratima Nangia‐Makker, Steven M. Firestine, Malathy P.V. Shekhar · 2025 · Pharmaceutical Research
- Drosophila Metaxin-2 controls beta-barrel protein biogenesis and muscle growth in a stage-dependent fashionXinyi Shou, Xiaoyu Fan, Ling Li, Yina Ruan, Wei Li, Weina Shang, Jianhua Mao, Xiaojun Xie · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- The cell autonomous and non-autonomous functions of Rab27 in longevity and neuroprotection in DrosophilaChia-Heng Hsu, Yi‐Jhan Li, Ting-Ni Guo, Fei‐Yang Tzou, Cheng-Li Hong, Chin‐Hsien Lin, Shu‐Yi Huang, Chih‐Chiang Chan · 2025 · Autophagy
- Cytosolic mtDNA and associated EYA-mediated pro-inflammatory signaling modulate healthspan in DrosophilaDavid W. Walker, Ricardo Aparicio, Roberta Alessi, Agathe Solans, Matin Mojdeh, Vartika Sharma, Paul Oh, Matea J. Zelich, Toby Frank, Jae Hur · 2025 · Research Square
- Decanoic acid extends lifespan and modulates metabolism in models of PLA2G6 -associated neurodegenerationBiqin Zhang, E. Dunn, Robin S. B. Williams, Stuart G. Snowden, Hrvoje Augustin · 2025 · Disease Models & Mechanisms
- Additional file 1 of Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin modelsMartinez, Aitor, Álvaro Sánchez-Martínez, Jake T. Pickering, Madeleine J. Twyning, Ana Terriente-Félix, Chen, Po-Lin, Chen, Chun-Hong, Alexander J. Whitworth · 2024 · Figshare
- Lysosomal abundance in young and aged mouse hearts assessed by In Vivo Imaging Systems (IVIS) Lysotracker imaging and autophagy-related gene expressionJawaher Albulushi, Hannah Coghlan, Mohesh Moothanchery, Aiswarya Dev, Emily Akerman, Jasmine Heenan, Nordine Helassa, Oluwatobi Samuel Adegbite, Parveen Sharma, Fenil Patel et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Age-related changes in lysosomal abundance in mouse hearts assessed by Lysotracker fluorescence imaging and autophagy gene expression analysisJawaher Albulushi, Hannah Coghlan, Mohesh Moothanchery, Aiswarya Dev, Emily Akerman, Jasmine Heenan, Nordine Helassa, Oluwatobi Samuel Adegbite, Parveen Sharma, Fenil Patel et al. · 2026 · The International Journal of Cardiovascular Imaging
- Drosophila Myc ameliorates defects in mitochondrial homeostasis and muscle maturation caused by Metaxin-2 deficiencyXinyi Shou, Xiaoyu Fan, Ling Li, Yina Ruan, Wenhua Li, Weina Shang, Jianhua Mao, Xiaojun Xie · 2026 · Proceedings of the National Academy of Sciences