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Cited by 322

The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.

NAD+ Repletion Rescues Female Fertility during Reproductive Aging

Open access
Bertoldo, Michael J., Listijono, Dave R., Ho, Wing-Hong Jonathan, Riepsamen, Angelique H., Goss, Dale M., Richani, Dulama, Jin, Xing L., Mahbub, Saabah, Campbell, Jared M., Habibalahi, Abbas, Loh, Wei-Guo Nicholas, Youngson, Neil A., Maniam, Jayanthi, Wong, Ashley S.A., Selesniemi, Kaisa, Bustamante, Sonia, Li, Catherine, Zhao, Yiqing, Marinova, Maria B., Kim, Lynn-Jee, Lau, Laurin, Wu, Rachael M., Mikolaizak, A. Stefanie, Araki, Toshiyuki, Le Couteur, David G., Turner, Nigel, Morris, Margaret J., Walters, Kirsty A., Goldys, Ewa, O’Neill, Christopher, Gilchrist, Robert B., Sinclair, David A., Homer, Hayden A., Wu, Lindsay E.·2020·Cell Reports
DOI 10.1016/j.celrep.2020.01.058
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Abstract

Reproductive aging in female mammals is an irreversible process associated with declining oocyte quality, which is the rate-limiting factor to fertility.Here, we show that this loss of oocyte quality with age accompanies declining levels of the prominent metabolic cofactor nicotinamide adenine dinucleotide (NAD + ).Treatment with the NAD + metabolic precursor nicotinamide mononucleotide (NMN) rejuvenates oocyte quality in aged animals, leading to restoration in fertility, and this can be recapitulated by transgenic overexpression of the NAD + -dependent deacylase SIRT2, though deletion of this enzyme does not impair oocyte quality.These benefits of NMN extend to the developing embryo, where supplementation reverses the adverse effect of maternal age on developmental milestones.These findings suggest that late-life restoration of NAD + levels represents an opportunity to rescue female reproductive function in mammals.

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Research works printed but not linked: 4

  1. Janny, 1996, Maternal age effect on early human embryonic development and blastocyst formation, Mol. Reprod. Dev., 45, 31, 10.1002/(SICI)1098-2795(199609)45:1<31::AID-MRD4>3.0.CO;2-T · doi:10.1002/(sici)1098-2795(199609)45:1<31::aid-mrd4>3.0.co;2-t
  2. Li, 2016, Extending prematuration with cAMP modulators enhances the cumulus contribution to oocyte antioxidant defence and oocyte quality via gap junctions, Hum. Reprod., 31, 810, 10.1093/humrep/dew020 · doi:10.1093/humrep/dew020
  3. O’Neill, 1997, Evidence for the requirement of autocrine growth factors for development of mouse preimplantation embryos in vitro, Biol. Reprod., 56, 229, 10.1095/biolreprod56.1.229 · doi:10.1095/biolreprod56.1.229
  4. Riepsamen, 2015, Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes, PLoS ONE, 10, e0126194, 10.1371/journal.pone.0126194 · doi:10.1371/journal.pone.0126194

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Metadata

Authors
Bertoldo, M. J., Listijono, D. R., Ho, W.-H. J., Riepsamen, A. H., Goss, D. M., Richani, D., Jin, X. L., Mahbub, S., Campbell, J. M., Habibalahi, A., Loh, W.-G. N., Youngson, N. A., Maniam, J., Wong, A. S. A., Selesniemi, K., Bustamante, S., Li, C., Zhao, Y., Marinova, M. B., Kim, L.-J., Lau, L., Wu, R. M., Mikolaizak, A. S., Araki, T., Le Couteur, D. G., Turner, N., Morris, M. J., Walters, K. A., Goldys, E., O’Neill, C., Gilchrist, R. B., Sinclair, D. A., Homer, H. A., & Wu, L. E.
Venue
Cell Reports
Publisher
Elsevier BV
Published
2020-02
Volume
30
Issue
6
Pages
1670-1681.e7
ISSN
2211-1247 (ISSN-L)
DOI
10.1016/j.celrep.2020.01.058
OpenAlex
W3005675840
Cited by
322
References
73
FWCI
28.22
Type
journal article
Language
en
Open access
gold
Licence
Funders
  • National Health and Medical Research Council (APP1044295, APP1066172, APP1103689, APP1122484, APP1127821, APP1139763)
  • Mayo Clinic
  • Harvard Medical School
  • Australian Research Council (CE140100003, DP170101863)

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CoChat. (2026). Citation check: NAD+ Repletion Rescues Female Fertility during Reproductive Aging. https://app.cochat.ai/papers/10.1016/j.celrep.2020.01.058
The paper
Bertoldo, M. J., Listijono, D. R., Ho, W.-H. J., Riepsamen, A. H., Goss, D. M., Richani, D., Jin, X. L., Mahbub, S., Campbell, J. M., Habibalahi, A., Loh, W.-G. N., Youngson, N. A., Maniam, J., Wong, A. S. A., Selesniemi, K., Bustamante, S., Li, C., Zhao, Y., Marinova, M. B., . . . Wu, L. E. (2020). NAD+ Repletion Rescues Female Fertility during Reproductive Aging. Cell Reports. https://doi.org/10.1016/j.celrep.2020.01.058

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.