Alzheimer’s Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation
Srinivasan, Karpagam, Friedman, Brad A., Etxeberria, Ainhoa, Huntley, Melanie A., van der Brug, Marcel P., Foreman, Oded, Paw, Jonathan S., Modrusan, Zora +3 more·2020·Cell Reports
Cited by (439)
Items 201–300 of 439
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- Bioinformatics analyses of significant genes, related pathways and candidate prognostic biomarkers in Alzheimer’s diseaseBasavaraj Mallikarjunayya Vastrad, Chanabasayya Mallikarjunayya Vastrad · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
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- Tissue-specific features of microglial innate immune responsesRaissa Timmerman, Saskia Maria Burm, Jeffrey John Bajramovic · 2020 · Neurochemistry International
- Outcome-Guided Sparse K-Means for Disease Subtype Discovery via Integrating Phenotypic Data with High-Dimensional Transcriptomic DataLingsong Meng, Dorina Avram, George C. Tseng, Zhiguang Huo · 2021 · Journal of the Royal Statistical Society Series C (Applied Statistics)
- A landscape of the genetic and cellular heterogeneity in Alzheimer diseaseLogan Brase, Shih‐Feng You, Ricardo D’Oliveira Albanus, Jorge L. Del‐Aguila, Yaoyi Dai, Brenna C. Novotny, Carolina Soriano‐Tárraga, Taitea Dykstra, María Victoria Fernández, John Budde et al. · 2021 · medRxiv
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- Retinal manifestations and their diagnostic significance in Alzheimer's diseaseSurabhi D. Abhyankar, Karis Little, Alan W. Stitt, Ashay Dilip Bhatwadekar · 2025 · Journal of Alzheimer s Disease Reports
- Repopulation of microglia and its implications for CNS disorders: Insights from the single-cell eraCong Chen, Guanjia Qiao, Dantong Tang, Fengling Xu, Jiawen Dong, Jinpan Zhang, Boru Jin · 2025 · Neurobiology of Disease
- Neuroimmune Dysregulation and AI-Driven Therapeutic Strategies in Alzheimer’s DiseaseShampa Ghosh, Rakesh Bhaskar, Dr. Krishna Kumar Singh, Samarth Sharma, Bhuvaneshwar Yarlagadda, Jitendra Kumar Sinha, Sung Soo Han · 2025 · Cellular and Molecular Neurobiology
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