Meta-Analysis of the Alzheimer’s Disease Human Brain Transcriptome and Functional Dissection in Mouse Models
Wan, Ying-Wooi, Al-Ouran, Rami, Mangleburg, Carl G., Perumal, Thanneer M., Lee, Tom V., Allison, Katherine, Swarup, Vivek, Funk, Cory C. +56 more·2020·Cell Reports
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- Transcriptional landscape of human microglia reveals robust gene expression signatures that implicates age, sex and APOE-related immunometabolic pathway perturbationsTulsi Patel, Troy Carnwath, Xue Wang, Mariet Allen, Sarah Lincoln, Laura J. Lewis‐Tuffin, Zachary Quicksall, Shu Lin, Frederick Q Tutor‐New, Charlotte C.G. Ho et al. · 2021 · Research Square
- APOEe4.Trem2*R47H Mice Show Changes in Alzheimer’s Disease-Relevant Processes in the Absence of Amyloid PlaquesKevin P. Kotredes, Adrian L. Oblak, Ravi S. Pandey, Peter Bor‐Chian Lin, Dylan T. Garceau, Harriet M. Williams, Asli Uyar, Rita O’Rourke, Sarah O’Rourke, Cynthia M. Ingraham et al. · 2021 · Research Square
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- Additional file 4 of SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer’s diseaseMaria Bichmann, Nuria Prat Oriol, Ebru Ercan-Herbst, David C. Schöndorf, Borja Gomez Ramos, Vera Schwärzler, Neu, Marie, Annabelle Schlüter, Xue Wang, Liang Jin et al. · 2021 · Figshare
- Systems genetic dissection of Alzheimer’s disease brain gene expression networksPinghan Zhao, Omar El Fadel, Anh Le, Carl Grant Mangleburg, Justin S. Dhindsa, Timothy Wu, Jinghan Zhao, Meichen Huang, Bismark Kojo Amoh, Aditi Sai Marella et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Mitochondrial energy production genes affecting reactive oxygen species and ATP synthesis, inflammatory pathways, and neuron viability are differentially expressed in brains of Alzheimer's disease patientsHaley K Pflanzer, Kimberly A Kerns, Joseph A. Knoble, Blake S Gershon, Jason Shugoll, Morgan G. Shelton, Randolph A. Coleman, Frank J. Castora · 2025 · Journal of Alzheimer s Disease
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- Metabolic Trans-Omic Analysis Reveals Key Regulatory Disruption of Energy Metabolism in Alzheimer’s DiseaseTomoharu Katayama, Hikaru Sugimoto, Keigo Morita, Hirohisa Watanabe, Shinya Kuroda · 2025 · eLife
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- Trem2 R47H and reduced TREM2 expression both mimic human Alzheimer’s disease signatures in miceT. Abel, Ravi S. Pandey, Annat Haber, Dylan T. Garceau, Michael Sasner, Kevin P. Kotredes, Gregory A. Cary, Adrian L. Oblak, Gareth R. Howell, Bruce T. Lamb et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Additional file 1 of miR-129-5p as a biomarker for pathology and cognitive decline in Alzheimer’s diseaseHan, Sang-Won, Pyun, Jung-Min, Paula J. Bice, Bennett, David A., Andrew J. Saykin, Kim, Sang Yun, Young Ho Park, Kwangsik T. Nho · 2024 · Figshare
- Additional file 2 of SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer’s diseaseMaria Bichmann, Prat Oriol, Nuria, Ebru Ercan-Herbst, David C. Schöndorf, Gomez Ramos, Borja, Vera Schwärzler, Marie Astrid Neu, Annabelle Schlüter, Wang, Xue, Liang Jin et al. · 2021 · Figshare
- Additional file 5 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaquesKristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
- Additional file 10 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaquesKristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
- Additional file 3 of SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer’s diseaseMaria Bichmann, Prat Oriol, Nuria, Ebru Ercan-Herbst, David C. Schöndorf, Gomez Ramos, Borja, Vera Schwärzler, Marie Astrid Neu, Annabelle Schlüter, Wang, Xue, Jin, Liang et al. · 2021 · Figshare
- Additional file 17 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaquesKristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
- Additional file 7 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaquesKristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
- Additional file 3 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaquesKristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
- Additional file 16 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaquesKristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
- Additional file 18 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaquesKristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
- Additional file 1 of Integrated analysis of the aging brain transcriptome and proteome in tauopathyCarl Grant Mangleburg, Timothy Wu, Hari Krishna Yalamanchili, Caiwei Guo, Hsieh, Yi-Chen, Duong, Duc M., Eric B. Dammer, Philip L. De Jager, Nicholas T. Seyfried, Zhandong Liu et al. · 2020 · Figshare
- Additional file 2 of miR-129-5p as a biomarker for pathology and cognitive decline in Alzheimer’s diseaseHan, Sang-Won, Pyun, Jung-Min, Paula J. Bice, Bennett, David A., Andrew J. Saykin, Kim, Sang Yun, Young Ho Park, Kwangsik Nho · 2024 · Figshare
- Additional file 12 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaquesKristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
- Additional file 1 of Genome-wide analysis identifies a novel LINC-PINT splice variant associated with vascular amyloid pathology in Alzheimer’s diseaseJoseph S. Reddy, Mariet Allen, Charlotte C.G. Ho, Stephanie R. Oatman, Özkan İş, Zachary Quicksall, Xue Wang, Jin, Jiangli, Patel, Tulsi A., Troy Carnwath et al. · 2021 · Figshare
- Additional file 6 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaquesKristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
- Additional file 2 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaquesKristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
- Additional file 9 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaquesKristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
- Additional file 14 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaquesKristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
- Additional file 1 of SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer’s diseaseMaria Bichmann, Prat Oriol, Nuria, Ebru Ercan-Herbst, David C. Schöndorf, Gomez Ramos, Borja, Vera Schwärzler, Marie Astrid Neu, Annabelle Schlüter, Wang, Xue, Jin, Liang et al. · 2021 · Figshare
- Additional file 13 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaquesKristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
- Additional file 15 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaquesKristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
- Additional file 4 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaquesKristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
- Additional file 8 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaquesKristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
- Additional file 11 of A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaquesKristine M. Tran, Shimako Kawauchi, Enikö A. Kramár, Narges Rezaie, Heidi Yahan Liang, Jasmine Sakr, Ángela Gómez-Arboledas, Miguel A. Arreola, Celia Da Cunha, Jimmy Phan et al. · 2023 · Figshare
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