GLP-1 Receptor Agonist NLY01 Reduces Retinal Inflammation and Neuron Death Secondary to Ocular Hypertension

Sterling, Jacob K., Adetunji, Modupe O., Guttha, Samyuktha, Bargoud, Albert R., Uyhazi, Katherine E., Ross, Ahmara G., Dunaief, Joshua L., Cui, Qi N.·2020·Cell Reports

Cited by (148)

Items 101–148 of 148

  1. Pathologic α-Synuclein-NOD2 Interaction and RIPK2 Activation Drives Microglia-Induced Neuroinflammation in Parkinson’s Disease
    Bo Am Seo, Seung‐Hwan Kwon, Donghoon Kim, Han-Byeol Kim, Shixun Ma, Kundlik Gadhave, Noelle Burgess, Xiaobo Mao, Liana S. Rosenthal, Javier Redding‐Ochoa et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  2. Mechanistic Role of Astrocytic Rac1 Protein in Alzheimer's Disease
    Fengwen Jiang, Niya Wang, Qiang Meng · 2025 · Aging and Disease
  3. Unraveling the immune response in optic nerve injury: implications for retinal ganglion cell protection
    Kexin Xu, Lu Yu, Ningzhi Zhang, Min Dong, Yiqiao Xing, Ning Yang · 2025 · Frontiers in Immunology
  4. GLP-1 medicine and non-arteritic anterior ischemic optic neuropathy: Literature review and perspectives
    Jia Nuo Feng, Yanming Chen, Tianru Jin · 2025 · Metabolism and Diseases
  5. Glaucoma Risk Reduction as a Secondary Benefit of Glucagon-like Peptide-1 Receptor Agonists: A Review of Emerging Evidence
    Mary V Lang, Pranav Vasu, Emily A. Dorairaj, Shibal Bhartiya, Syril Kumar Dorairaj · 2025 · JOURNAL OF CURRENT GLAUCOMA PRACTICE
  6. Pharmacological Blockade of LPAR1 Does Not Provide Neuroprotection in a Rat Model of Ocular Hypertensive Glaucoma
    Sai Kocherlakota, Alan Nicol, Filippo Locri, Karin J. Stebbins, Daniel S. Lorrain, James R. Tribble, Pete A. Williams · 2026 · Translational Vision Science & Technology
  7. The internal limiting basement membrane inhibits functional engraftment of transplanted human retinal ganglion cells in vivo
    Erika A. Aguzzi, Stella Mary, Marzieh Mowlavi Vardanjani, Dayn R. Godinez, Elizabeth C. Kimball, Behnoosh Bonakdar, Kevin Yang Zhang, Jian Du, Arumugam Nagalingam, William H. Yutzy et al. · 2026 · Science Translational Medicine
  8. Timing and duration of glucagon‐like peptide‐1 receptor agonist use and risk of nonarteritic anterior ischaemic optic neuropathy
    Siar Niazi, Filip Gnesin, Baker Nawfal Jawad, Zia Niazi, Puriya Daniel Würtz Yazdanfard, Anne Pernille Toft‐Petersen, Kathrine Kold Sørensen, Amani Meaidi, Yousif Subhi, Christian Tobias Torp-Pedersen · 2026 · Acta Ophthalmologica
  9. Glucagon-Like Peptide 1 Receptor Agonists and Age-Related Macular Degeneration Incidence
    Shahin Hallaj, Takashi Nishida, Alireza Kamalipour, Chris Longhurst, William R. Freeman, Sally L. Baxter, Aaron E. Boussina · 2026 · Ophthalmology Retina
  10. Neuroprotective Properties of Peptides
    Oytun Erbaş, İlknur Altuntaş, Pemra Nesil, Hadi Sasanı, Mehtap Odabaşı · 2023 · IntechOpen eBooks
  11. A pedigree with retinitis pigmentosa and its concomitant ophthalmic diseases
    Hong-Dou Luo, Ai-Jia Wang, Xue-Qing Yu, Haijian Hu, Ling Zeng, Feifei Wang, Ming J. Jin, Xu Zhang · 2023 · International Journal of Ophthalmology
  12. Silencing neuroinflammatory reactive astrocyte activating factors ameliorates disease outcomes in perinatal white matter injury
    Patricia Renz, Daniel Surbek, Valérie Haesler, Vera Tscherrig, Eric Jinsheng Huang, Manideep Chavali, Shane Antony Liddelow, David H. Rowitch, Andreina Schoeberlein, Amanda Brosius Lutz · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  13. Blocking Formation of Neurotoxic Reactive Astrocytes is Beneficial Following Stroke
    Kimberly Prescott, Alexandra E. Münch, Evan Brahms, Maya K. Weigel, Kenya Inoue, Marion S. Buckwalter, Shane Antony Liddelow, Todd C. Peterson · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  14. The Benefits and Risks of Glucagon-Like Peptide-1 Receptor Agonists on Ocular Diseases: A Narrative Review
    Jacky Xiao Feng Huang, Joshua Wu, Hunain Ahmad, Jason Li, Samaantar Joshi, Adil Yousaf, Rishita Pemminati, Sudhakar Pemminati · 2026 · Cureus
  15. Exendin-4 averts all-trans-retinal-driven damage to photoreceptors and the retina via the GLP-1R/PKA/CREB1 signaling axis
    Beiting He, Yuling Chen, Peixin Cai, Ruitong Xi, Xiaoqing Shen, Shuting Guo, Jun Chen, Shiying Li, Yalin Wu · 2026 · Cellular & Molecular Biology Letters
  16. Neuroinflammation in glaucoma: a myriad of cellular pathways and players
    Michael MacLean, Sean D. Lydon, Cátia Gomes, Elizabeth M. Pizzi, Cory A. Diemler, Sarah E. R. Yablonski, Gareth R. Howell, Jason S. Meyer, Richard T. Libby · 2026 · Mammalian Genome
  17. Microglia suppress Müller cell FGF1 and contribute to retinal ganglion cell degeneration in glaucoma
    Yang Sui, Siti Tong, Zhe Qin, Pingxiu Dang, Tianyi Sui, Yabo Ma, Jiabin Wang, Yajing Zhao, Shipeng Wang, Shaojun Wang et al. · 2026 · Experimental Eye Research
  18. Rapid Morphologic and Molecular Activation of Microglial Cells by Stimulation of the P2X7 Receptor Correlates with Neuron Loss
    Keith E. Campagno, Wennan Lu, Assraa Hassan Jassim, Farraj Albalawi, Aurora Cenaj, Huen‐Yee Tso, Sophia P. Clark, Puttipong Sripinun, Néstor Más Gómez, Claire H. Mitchell · 2021 · Research Square
  19. Impact of GLP-1 Receptor Agonists on Intraocular Pressure in Glaucoma: A Case Series
    Catherine Johnson, Jesse A. Terrell, Lauren S. Blieden, Barbara M. Wirostko · 2024 · SSRN Electronic Journal
  20. Engineering a 3D hydrogel system to study optic nerve head astrocyte morphology and behavior in response to glaucomatous insult
    Ana Nicolle Strat, Alexander Kirschner, Hannah Yoo, Ayushi Singh, Tyler Bagué, Haiyan Li, Samuel Herberg, Preethi S. Ganapathy · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  21. Association of TNF-α gene promoter polymorphism with primary open-angle glaucoma
    A.V. Shevchenko, В. Ф. Прокофьев, Vladimir Iosifovich Konenkov, Еремина Алена Викторовна, Novosibirsk Branch of the S. Fyodorov Eye Microsurgery Federal State Institution, Novosibirsk, Russian Federation, А. Н. Трунов, Novosibirsk Branch of the S. Fyodorov Eye Microsurgery Federal State Institution, Novosibirsk, Russian Federation, V. V. Chernykh, Novosibirsk Branch of the S. Fyodorov Eye Microsurgery Federal State Institution, Novosibirsk, Russian Federation · 2022 · Russian Journal of Clinical Ophthalmology
  22. Drug Repurposing Patent Applications January–March 2023
    Hermann AM Mucke · 2023 · Assay and Drug Development Technologies
  23. Impact of Type 2 Diabetes Mellitus-Related Factors on Glaucoma: a Comprehensive Review
    Aliya Abbas Rizvi, Mohammad Abbas, Asma Imran Ansari, Shrikant Verma, Sushma Verma, Luxmi Singh, Farzana Mahdi · 2023 · Current Ophthalmology Reports
  24. Double-edge sword: Positive and negative effects of inflammation on axonal regeneration
    Alexander W. Venanzi, Abigail S. Hackam · 2025 · Elsevier eBooks
  25. Genetically Predicted Immunocyte Phenotypes as Risk and Protective Factors in Glaucoma: An Exploratory Bidirectional Mendelian Randomization Study
    Yanggang Hong, Wanyi Shu, Yi Wang, Yarong Wang, Jiani Jiang, Gaoying Jin, Han Chen, Лин Фу · 2025 · Translational Vision Science & Technology
  26. Additional file 2 of Rapid morphologic changes to microglial cells and upregulation of mixed microglial activation state markers induced by P2X7 receptor stimulation and increased intraocular pressure
    Keith E. Campagno, Wennan Lu, Assraa Hassan Jassim, Farraj Albalawi, Aurora Cenaj, Tso, Huen-Yee, Sophia P. Clark, Puttipong Sripinun, Néstor Gómez, Claire H. Mitchell · 2021 · Figshare
  27. Additional file 1 of Rapid morphologic changes to microglial cells and upregulation of mixed microglial activation state markers induced by P2X7 receptor stimulation and increased intraocular pressure
    Keith E. Campagno, Wennan Lu, Assraa Hassan Jassim, Farraj Albalawi, Aurora Cenaj, Tso, Huen-Yee, Sophia P. Clark, Puttipong Sripinun, Néstor Gómez, Claire H. Mitchell · 2021 · Figshare
  28. Additional file 1 of Human adipose tissue-derived stem cell extracellular vesicles attenuate ocular hypertension-induced retinal ganglion cell damage by inhibiting microglia- TLR4/MAPK/NF-κB proinflammatory cascade signaling
    Ji, Shangli, Peng, Yanfang, Liu, Jian, Xu, Pang, Tang, Shibo · 2024 · Figshare
  29. Additional file 1 of Glucagon-like peptide-1 receptor agonists and diabetic retinopathy: nationwide cohort and Mendelian randomization studies
    Deqiang Zheng, Ning Li, Hou, Rui, Zhang, Xiaoyu, Wu, Lijuan, Jan Sundquist, Kristina Sundquist, Jianguang Ji · 2023 · Figshare
  30. Evaluating the Ocular Safety Profile of Glucagon-Like Peptide-1 Receptor Agonists
    Zaid Khan, Fatima W. Chaudhry, Neal Dhar, Rohit S. Adyanthaya · 2025 · Research Square
  31. Semaglutide and the Effects of Glucagon-like Peptide-1 on Vision
    Rajesh Rajput, Hridish Narayan Chakravarti, Jothydev Kesavadev, RAJIV R. KOVIL, Siddhant Rajput · 2026 · International Journal of Diabetes and Technology
  32. Pro-Con: Antiobesity Drugs Such as Glucagon-Like Peptide-1 Receptor Agonists Should Be a First-Line Treatment in Idiopathic Intracranial Hypertension
    Maria G. Lange, Aroucha Vickers, Lisa J. Hill, Susan P. Mollan, James Mitchell, Alexandra J. Sinclair, Andrew G. Lee · 2026 · Journal of Neuro-Ophthalmology
  33. Association between GLP-1 receptor agonist use and glaucoma risk: a systematic review and meta-analysis
    Luke M. Yaldo, Rahul Kumar, Alex Ngo, Albert Ting, Abdelaziz Abdelaal, Joshua Ong, Ethan Waisberg · 2026 · Expert Review of Ophthalmology
  34. Transient Effects of Exenatide on Intraocular Pressure in a Rat Bone Defect Model
    Candemir Özcan, Ayşe Başak Dellalbaşı, Elif Doğan, Fatih Uğur, Recep Taşkın · 2026 · Dicle Üniversitesi Veteriner Fakültesi Dergisi
  35. GLP-1 receptor agonists and age-related macular degeneration risk in diabetes or non-diabetic obesity: A retrospective cohort study
    Ssu‐Yu Pan, Chien‐Hsiang Weng, Yi‐Jing Sheen, Shang-Feng Tsai, Jun‐Fu Lin, Junpeng Chen, Ching‐Heng Lin, Shun-Ping Huang, Chia-Jen Chang, Hui-Ju Lin et al. · 2026 · The American Journal of Medicine
  36. Beyond intraocular pressure: vascular and metabolic modifiers of optic nerve vulnerability in glaucoma
    Balaji Lakavath, B. Senthil Kumar, Prabhudas Nelaturi · 2026 · International Ophthalmology
  37. The human retina in Alzheimer’s disease: Pathology, mechanisms, and biomarkers
    Luis Pérez de Sevilla Müller, Sriparna Majumdar, Brandy S. Recio · 2026 · Ageing Research Reviews
  38. Neuroimmune interactions in retinal ganglion cell degeneration
    Baohua Li, Yipeng Shi, Ke Song, Mingming Zhang, Yixian Yan, Bobiao Ning, 亢泽峰 · 2026 · Cell Communication and Signaling
  39. C1q dependency of retinal ganglion cell death in blast-mediated traumatic brain injury
    Adam Hedberg‐Buenz, Laura M. Dutca, Nickolas Boehme, Ashelyn Mann, Matthew M. Harper, Mona K. Garvin, Michael G. Anderson · 2026 · Experimental Eye Research
  40. Adenylyl Cyclase (ADCY) Protein Family: Molecular Mechanisms and Therapeutic Potential in Glucose and Lipid Metabolism and Feeding Regulation
    Shaohong Wu, Yongxue Chen, Jiali Xueting Zhang, Jinshan Zhang · 2026 · Journal of Cellular Physiology
  41. Dual-Pathway Astrocyte Failure in Parkinson’s Disease: Therapeutic Targeting of Nrf2/TFEB Suppression and cGAS-STING/Ferroptosis Activation
    Ahmed M Abdelaziz · 2026 · Molecular Neurobiology
  42. Extrinsic Regulation of Optic Nerve Axon Regeneration in the Adult Central Nervous System
    Arissa Adhikary, Emily A. Dorairaj, Alex Arshavsky, Shanti Ramcharan, Krishna S. Kishor, Sanjoy K. Bhattacharya · 2026 · Cells
  43. Putative mechanisms of ocular inflammation in syphilis
    Liam M. Ashander, João M. Furtado, Keryn A. Williams, Giles Best, Melissa H. Brown, Justine R. Smith · 2026 · Journal of Ophthalmic Inflammation and Infection
  44. Divergent ocular safety profiles of glucagon-like peptide-1 receptor agonists: a pharmacological heterogeneity framework
    Huili Li, Shengke Peng, Daoxi Lei · 2026 · Frontiers in Medicine
  45. Impact of Glucagon-Like Peptide 1 (GLP-1) and Gastric Inhibitory Polypeptide (GIP) Receptor Agonists on Intraocular Pressure in Glaucoma: A Case Series
    Coy Steel, Catherine Johnson, Chase Paulson, Jesse A. Terrell, Qi N Cui, Lauren Blieden, Barbara Wirostko · 2026 · Journal of Ophthalmology and Advance Research
  46. The eye in the era of GLP-1 receptor agonists ‒ a narrative review of current evidence
    Hanna Rusinek, Joanna Korniluk, Natalia Milusz, Weronika Dmoch, Piotr Maciejewicz · 2026 · European Journal of Clinical and Experimental Medicine
  47. FFAs secreted by A1 astrocytes contribute to RGCs apoptosis via PERK/eIF2α/ATF4/CHOP pathway in retinal ischemia/reperfusion injury
    Wenjia Shi, Can Liu, Jiangcheng Yang, Liangshi Qin, Junle Liao, Jufang Huang, Zhaolin Gao, Dan Chen · 2026 · Tissue and Cell
  48. Glaucoma neurodegeneration: targeted modulation of intraocular immune pathways – a review of novel therapeutic advances
    Yunyun Sun, Keyun Xue, Congqin Wen, Xinyan Ma, Xiaojie Hu · 2026 · Frontiers in Immunology