ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism

Qi, Guoyuan, Mi, Yashi, Shi, Xiaojian, Gu, Haiwei, Brinton, Roberta Diaz, Yin, Fei·2021·Cell Reports
DOI 10.1016/j.celrep.2020.108572

Cited by (384)

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  11. Identification and analysis of immunogenicity and immunotherapy efficacy by fatty acid genes: a novel prognostic features of lumbar disc herniation and Mendelian randomization analysis
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  12. Cell-type-specific mapping of enhancers and target genes from single-cell multimodal data
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  13. Propofol suppressed cell proliferation through inhibition of SREBP1c-mediated De novo lipogenesis in colorectal cancer cells
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  14. Association of APOE ε4 with cerebrospinal fluid protein and amyloid-β 42 levels in Alzheimer's disease
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  15. Altered Lipid Landscapes Provide a Molecular Perspective on Schizophrenia
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  17. Additional file 2 of APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis
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  18. Additional file 7 of Distinct forebrain regions define a dichotomous astrocytic profile in multiple system atrophy
    Yanni Schneider, Carina Gauer, Andert, M., Alana Hoffmann, Riemenschneider, M. J., Krebs, W., Chalmers, N., C Lötzsch, Naumann, U. J., Xiang, W. et al. · 2024 · Figshare
  19. Additional file 1 of APOE deficiency impacts neural differentiation and cholesterol biosynthesis in human iPSC-derived cerebral organoids
    Zhao, Jing, Tadafumi C. Ikezu, Wenyan Lü, Jesse R. Macyczko, Yonghe Li, Laura J. Lewis‐Tuffin, Yuka A. Martens, Yingxue Ren, Yiyang Zhu, Yan W. Asmann et al. · 2023 · Figshare
  20. Additional file 1 of A novel apoE-mimetic increases brain apoE levels, reduces Aβ pathology and improves memory when treated before onset of pathology in male mice that express APOE3
    Ana Carolina Valencia‐Olvera, Deebika Balu, Shreya Bellur, Thomas P. McNally, Yaseen Saleh, Pham, Don, Shivesh Ghura, Jason M. York, Jan O. Johansson, Mary Jo LaDu et al. · 2023 · Figshare
  21. Additional file 5 of Distinct forebrain regions define a dichotomous astrocytic profile in multiple system atrophy
    Yanni Schneider, Carina Gauer, Andert, M., Alana Hoffmann, Riemenschneider, M. J., Krebs, W., Chalmers, N., C Lötzsch, Naumann, U. J., Xiang, W. et al. · 2024 · Figshare
  22. Additional file 2 of A novel apoE-mimetic increases brain apoE levels, reduces Aβ pathology and improves memory when treated before onset of pathology in male mice that express APOE3
    Ana Carolina Valencia‐Olvera, Deebika Balu, Shreya Bellur, Thomas P. McNally, Yaseen Saleh, Pham, Don, Shivesh Ghura, Jason M. York, Jan O. Johansson, Mary Jo LaDu et al. · 2024 · Figshare
  23. Additional file 4 of A novel apoE-mimetic increases brain apoE levels, reduces Aβ pathology and improves memory when treated before onset of pathology in male mice that express APOE3
    Ana Carolina Valencia‐Olvera, Deebika Balu, Shreya Bellur, Thomas P. McNally, Yaseen Saleh, Pham, Don, Shivesh Ghura, Jason M. York, Jan O. Johansson, Mary Jo LaDu et al. · 2024 · Figshare
  24. Additional file 8 of Distinct forebrain regions define a dichotomous astrocytic profile in multiple system atrophy
    Yanni Schneider, Carina Gauer, Andert, M., Alana Hoffmann, Riemenschneider, M. J., Krebs, W., Chalmers, N., C Lötzsch, Naumann, U. J., Xiang, W. et al. · 2024 · Figshare
  25. Additional file 1 of Distinct forebrain regions define a dichotomous astrocytic profile in multiple system atrophy
    Yanni Schneider, Carina Gauer, Andert, M., Alana Hoffmann, Riemenschneider, M. J., Krebs, W., Chalmers, N., C Lötzsch, Naumann, U. J., Xiang, W. et al. · 2024 · Figshare
  26. Additional file 1 of Astrocyte metabolism of the medium-chain fatty acids octanoic acid and decanoic acid promotes GABA synthesis in neurons via elevated glutamine supply
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  27. Additional file 6 of Distinct forebrain regions define a dichotomous astrocytic profile in multiple system atrophy
    Yanni Schneider, Carina Gauer, Andert, M., Alana Hoffmann, Riemenschneider, M. J., Krebs, W., Chalmers, N., C Lötzsch, Naumann, U. J., Xiang, W. et al. · 2024 · Figshare
  28. Additional file 1 of Unlocking potential biomarkers bridging coronary atherosclerosis and pyrimidine metabolism-associated genes through an integrated bioinformatics and machine learning approach
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  29. Additional file 5 of A novel apoE-mimetic increases brain apoE levels, reduces Aβ pathology and improves memory when treated before onset of pathology in male mice that express APOE3
    Ana Carolina Valencia‐Olvera, Deebika Balu, Shreya Bellur, Thomas P. McNally, Yaseen Saleh, Pham, Don, Shivesh Ghura, Jason M. York, Jan O. Johansson, Mary Jo LaDu et al. · 2024 · Figshare
  30. Additional file 1 of Integration of bioinformatics and machine learning approaches for the validation of pyrimidine metabolism-related genes and their implications in immunotherapy for osteoporosis
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  31. Additional file 2 of Distinct forebrain regions define a dichotomous astrocytic profile in multiple system atrophy
    Yanni Schneider, Carina Gauer, Andert, M., Alana Hoffmann, Riemenschneider, M. J., Krebs, W., Chalmers, N., C Lötzsch, Naumann, U. J., Xiang, W. et al. · 2024 · Figshare
  32. Additional file 3 of A novel apoE-mimetic increases brain apoE levels, reduces Aβ pathology and improves memory when treated before onset of pathology in male mice that express APOE3
    Ana Carolina Valencia‐Olvera, Deebika Balu, Shreya Bellur, Thomas P. McNally, Yaseen Saleh, Pham, Don, Shivesh Ghura, Jason M. York, Jan O. Johansson, Mary Jo LaDu et al. · 2024 · Figshare
  33. Additional file 3 of Distinct forebrain regions define a dichotomous astrocytic profile in multiple system atrophy
    Yanni Schneider, Carina Gauer, Andert, M., Alana Hoffmann, Riemenschneider, M. J., Krebs, W., Chalmers, N., C Lötzsch, Naumann, U. J., Xiang, W. et al. · 2024 · Figshare
  34. Additional file 4 of Distinct forebrain regions define a dichotomous astrocytic profile in multiple system atrophy
    Yanni Schneider, Carina Gauer, Andert, M., Alana Hoffmann, Riemenschneider, M. J., Krebs, W., Chalmers, N., C Lötzsch, Naumann, U. J., Xiang, W. et al. · 2024 · Figshare
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  39. α-Linolenic acid-rich diet boosts docosahexaenoic acid levels and restores lipid balance in the brain parenchyma and vasculature of APOE4 mice
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  40. Étude des perturbations astrocytaires sous l’influence de l’apolipoprotéine E4 : implications et applications dans la maladie d’Alzheimer
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  42. Brain DHA increases in APOE3, but not in APOE4 mice, despite robust brain EPA increase during LPC n-3 supplementation in both genotypes
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