Glutaminase 1 deficiency confined in forebrain neurons causes autism spectrum disorder-like behaviors

Ji, Chenhui; Tang, Yalin; Zhang, Yanyan; Huang, Xiaoyan; Li, Congcong; Yang, Yuhong; Wu, Qihui; Xia, Xiaohuan; Cai, Qingyuan; Qi, Xin-Rui; Zheng, Jialin C.

doi:10.1016/j.celrep.2023.112712

Glutaminase 1 deficiency confined in forebrain neurons causes autism spectrum disorder-like behaviors

An abnormal glutamate signaling pathway has been proposed in the mechanisms of autism spectrum disorder (ASD). However, less is known about the involvement of alterations of glutaminase 1 (GLS1) in the pathophysiology of ASD. We show that the transcript level of GLS1 is significantly decreased in…