Microglia-astrocyte crosstalk in the amyloid plaque niche of an Alzheimer’s disease mouse model, as revealed by spatial transcriptomics
Mallach, Anna, Zielonka, Magdalena, van Lieshout, Veerle, An, Yanru, Khoo, Jia Hui, Vanheusden, Marisa, Chen, Wei-Ting, Moechars, Daan, Arancibia-Carcamo, I. Lorena, Fiers, Mark, De Strooper, Bart·2024·Cell Reports
Cited by (137)
Items 101–137 of 137
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- Spatial Multi-Omics Workflow and Analytical Guidelines for Alzheimer’s NeuropathologyXuehan Sun, Hannah R. Hudson, Timothy C. Orr, Srinivas Koutarapu, Alyssa B. Rosenbloom, Matthew H. Ingalls, Oliver Braubach, Christopher Dirk Keene, Joseph Beechem, Miranda E. Orr · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Fus depleted oligodendrocytes reduce neuronal damage and attenuate AD progression in the App NL-G-F mouseTe-Hsuan Tung, Sudhagar Babu, Xiangting Tang, Alec Sciutto, Micah A. Romer, Prathima Racha, Victoria M. Fiesler, Adrita Saha, Takashi Saito, Takaomi C. Saido et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Single Plaque Proteomics Reveals the Composition and Dynamics of the Amyloid Microenvironment in Alzheimer’s DiseaseMengqi Chu, Ju Wang, Jay M. Yarbro, Ping-Chung Chen, Him K. Shrestha, Huan Sun, Mingming Niu, Zhen Wang, Sarah Harvey, Zhiping Wu et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Spatially resolved transcriptomic identification of thousands of neurons recorded in vivoIsabelle Prankerd, Maxwell Shinn, Paul C. Shuker, Zhiyao Zhou, Reilly Tilbury, Joshua A. M. Duffield, Christina A. Maat, Dimitris Nicoloutsopoulos, Anne Ritoux, Paula Maglio Cauhy et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Lymphoid-like Suppressive Microglia in Alzheimer’s Disease: A New Neuroimmune Regulatory Axis?Chmiel, James, Gawełczyk, Wiktor, Soczyńska, Julia, Leszek, Jerzy · 2026 · Cells
- Boolean Network Modeling Identifies Cognitive Resilience in the First Murine Model of Asymptomatic Alzheimer’s DiseaseSuborno Jati, Sahar Taheri, Satadeepa Kal, Subhash C. Sinha, Brian Patrick Head, Sushil K. Mahata, Debashis Sahoo · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Glypican-5 delineates spatially distinct astrocyte and neuronal populations in the human hippocampus and is selectively remodelled in Alzheimer’s diseaseFélicia Jeannelle, Mónica Miranda de la Maza, Sophie Schreiner, Gaël Paul Hammer, Dominique Mirault, Naguib Mechawar, Brainbank Neuro-CEB Neuropathology Network, Netherlands Brain Bank, Michel Guy André Mittelbronn, David S. Bouvier · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Single-cell Spatial Transcriptional Profiling Uncovers Heterogeneous Cellular Responses to Pathogenic Tau in a Mouse Model of NeurodegenerationXuehan Sun, Lidan Wu, Timothy C. Orr, Ashley Heck, Kimberly Young, Nathan Dunaway, Jose Ceja Navarro, Joseph Beechem, Miranda E. Orr · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- sc4D: spatio-temporal single-cell transcriptomics analysis through embedded optimal transport identifies joint glial response to Alzheimer’s disease pathologyIshir Rao, M Kellis, Yosuke Tanigawa · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- A partition-based spatial entropy for co-occurrence analysis with broad applicationAdnane Nemri, Ovidiu Radulescu, Antoine Claessens, Thomas D. Otto · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Selective weakening of population-coupled synaptic activity in vivo in a mouse model of amyloid-beta pathologyLeire Melgosa-Ecenarro, Carola I. Radulescu, Nazanin Doostdar, Joe Airey, Francesca A. Chaloner, Nawal Zabouri, Giada Pedretti, Francesca Osso, Leire Garrido Perez, Kjara S Pilch et al. · 2026 · Nature Communications
- Glial metabolic states in human sporadic amyotrophic lateral sclerosis uncovered by spatial single-cell proteomics.Gen Ohtsuki, Momoka Hikosaka, Miyu Kinoshita, Kumiko Uemura, Md Shamim Hossain, Masako Abe, Md Sorwer Alam Parvez, Siwakorn Punyawatthananukool, Mari Yoshida, Tatsuaki Tsuruyama · 2026 · Research Square
- Microglial activation in diabetic neuropathic pain: Molecular trigger mechanisms, neuroimmune crosstalk, and emerging therapeutic targetsJilin Wang, Huamao Zhou · 2026 · Neuropeptides
- Glial pathology networks reveal early olfactory vulnerability in post mortem human Alzheimer's diseaseDa Hae Jung, Eunji Park, Hyeon Chang Ju, Cheil Moon, Ali Jahanshahi · 2026 · Alzheimer s & Dementia
- Biased multi-view contrastive learning with attentive masking for spatial transcriptomic analysisLaiyi Fu, Wenkai Cui, Yuehua Chen, Danyang Wu, Han Sun · 2026 · Briefings in Bioinformatics
- Spatially-resolved integration of microglia morphological diversity and gene expression using Visium with protein co-detectionJennifer S. Kim, Stephanie C. Hicks, Kristen R. Maynard, Paul Pavlidis, Annie Vogel Ciernia · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Astrocyte-driven multicellular mechanisms of CNS repair and cerebroprotectionKristopher E. Plambeck, Reina Hastings, Elena Blanco‐Suárez · 2026 · Journal of Cerebral Blood Flow & Metabolism
- ABCA7 rs3752231 variant effects on glial responses to amyloid-β and plaque maturation in Alzheimer’s diseaseMarianna Papageorgopoulou, Emily Adair, Nurun Nahar Fancy, Baptiste Avot, Samuel L Boulger, Mara S. Wülfing, Paul McMahan Matthews · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Microglia in Alzheimer’s disease: Insights into disease progression and therapyVaishali Saini, Srija Mukherjee, Chaitali Vora, Himanshi Jindal, Hem Chandra Jha · 2026 · Advances in immunology
- Standardized Extract of Ginkgo biloba L. Reverses Memory Impairment in Older Female Mice with Basal Forebrain Cholinergic DysfunctionBeatriz Gangale Muratori, Carlos R. Caetano, Irina Emanuela Tavares da Veiga, Andressa Gabriela Soliani, Sofia M. S. e Silva, Juliana P. Gava, Lucinéia Ferreira Ceridório, Luciano Caselli, Rodrigo Portes Ureshino, Carla M. Prado et al. · 2026 · Neurochemical Research
- DeepPlaque: a scalable multimodal platform for Aβ pathology and cell analysis in Alzheimer’s diseaseHiu Yi Wong, Cheng Jin, Sze Long Yuen, Xin Yang, Sunveer Singh Gill, Jiahui Xu, Kuo Pin Eric Lai, Wing‐Yu Fu, Weina Gao, Xi Wang et al. · 2026 · EMBO Molecular Medicine
- The Clearance-Centered Bottleneck in Alzheimer’s Disease: From Coupled Glymphatic–Lymphatic Circuits to Therapeutic OpportunitiesPeijuan Wu, Yuhui Liao, Changyan Liu, Xiaoying Liu, Qin Feng, Xunshu Cheng · 2026 · Molecular Neurobiology
- Hearing loss drives region-specific amyloid accumulation along the auditory pathway in female 5xFAD miceJiwon Park, Se Yeon Jeong, Jun Hee Kim · 2026 · Scientific Reports
- White and gray matter microstructural alterations in subjective cognitive decline: An exploratory study using TBSS and GBSSShuai Lin, Ming Xue, Chang Xu, Chenjun Sheng, Tianqi Wang, Jiali Sun, Yue Chen, Jianxiu Lian, Tong Zhang, Wei Wang · 2026 · Brain Research Bulletin
- Cellular state transitions in neuroimmune disordersMoawiah M. Naffaa · 2026 · Exploration of Immunology
- Decoding Synaptic Diversity: Molecular Architectures, Phase Transitions, and Shared Postsynaptic Failure in Alzheimer’s and Parkinson’s DiseaseGiovanni Luca Cipriano, Ivan Anchesi, Alessia Floramo, Veronica Argento, Sara Spinelli, Maria Francesca Astorino, Marco Calabrò, Osvaldo Artimagnella · 2026 · Cells
- P2X7 receptor-dependent microglia-astrocyte coupling in Alzheimer's disease: from eATP sensing to synaptic and proteostatic failureYiwen Li, Shiming Liu, 蓝娇 · 2026 · Frontiers in Aging Neuroscience
- Human Stem Cell-Derived Models of the Alzheimer’s Disease Neuroimmune SystemRose Summers, Daphne Quang, Noah R. Johnson · 2026 · International Journal of Molecular Sciences
- Neurodegeneration as a dysregulation of neuroimmune crosstalkF. Chris Bennett, Soyon Youngae Hong, Ning Jenny Jiang, Ivan Marazzi · 2026 · Cell
- Natural microbial enrichment modulates microglial states and transcriptional programs relevant to Alzheimer’s diseaseMohamed Lala Bouali, Amir Mohamed Kezai, Marc Bazin, Papa Yaya Badiane, Nasim eskandari, Véronique Lévesque, Justin Robillard, Steeve D. Côté, Denis Soulet, Cyntia Tremblay et al. · 2026 · Frontiers in Immunology
- Spatial omics of neuroinflammation: insights across brain diseasesMingming Li, Qianying Wang, Jian Li, Yanjun Liu, Lixia Chen, Pei Liu, Jia Guo · 2026 · Frontiers in Immunology
- Integrative analysis of single‐cell multi‐omics reveals heterogeneity in piriform cortex principal neurons and their selective vulnerability in Alzheimer's diseaseJiayue Meng, Miaomiao Zhang, Yujie Chen, Mengyao Han, Nianhao Cheng, Ruifang Cao, Qinwen He, Yaya Zhao, Liyun Yuan, Guoqing Zhang · 2026 · Clinical and Translational Medicine
- Astrocytes in Neurodegeneration: Spatial States, Crosstalk, and Emerging TherapiesLisa Steger, Veit Rothhammer, Friederike Zunke · 2026 · Molecular Neurobiology
- Microglia and neuroinflammation: An in‐depth analysis from functional diversity to disease mechanismsJie Chen, Wangzheqi Zhang, Lizhou Song, Yan Liao, Haoling Zhang, Yiyang Xia, Derong Cui · 2026 · Clinical and Translational Medicine
- Astrocytic synapse engulfment is differentially controlled by APOE genotypeSowmya Sekizar, Kristján Holt, Sharon Meyers, Makis Tzioras, Declan King, Jane Tulloch, Rosemary J. Jackson, Tara L. Spires‐Jones · 2026 · Neuroscience
- TSC1-mTORC1 signaling in Alzheimer’s disease: an integrated bioinformatic analysis linking gene expression to neuropathologyZheng Liu, Yuchen Yu, Yu Wang, Shuohan Ning, Tongshuai Huang, Jingqi Li, Sihan Fan, 卢超龙 · 2026 · Frontiers in Aging Neuroscience