Targeting microglial PPARα ameliorates the outcome of ischemic stroke by enhancing interaction with infiltrating peripheral monocytes/macrophages.

Ren, Tong; Zhu, Maoshu; Jiang, Xilin; Xu, Lanxi; Jin, Hao; Zhou, Yu; Zhao, Yun; Zhuo, Rengong; Li, Wenjun; Chen, Caixia; Peng, Lu; Jin, Xin; Li, Ying; Yang, Lichao

doi:10.1016/j.celrep.2025.115875

Targeting microglial PPARα ameliorates the outcome of ischemic stroke by enhancing interaction with infiltrating peripheral monocytes/macrophages.

The interaction between infiltrating immune cells and brain-resident cells is critical for inducing an inflammatory response to ischemic stroke. However, the direct effects of CD11b + CD45 int microglia in the brain on infiltrating CD11b + CD45 high Ly6G − monocytes/macrophages (Mos/MΦs) and the …