The DOI matches its Crossref record; 220 of the 220 references it cites were found in a registry or an index.
Systems Biology of Cancer Metastasis
Open accessAbstract
Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series of concurrent, partially overlapping processes, as successfully metastasizing cells assume new phenotypes while jettisoning older behaviors. The lack of a systemic understanding of this complex phenomenon has limited progress in developing treatments for metastatic disease. Because metastasis has traditionally been investigated in distinct physiological compartments, the integration of these complex and interlinked aspects remains a challenge for both systems-level experimental and computational modeling of metastasis. Here, we present some of the current perspectives on the complexity of cancer metastasis, the multiscale nature of its progression, and a systems-level view of the processes underlying the invasive spread of cancer cells. We also highlight the gaps in our current understanding of cancer metastasis as well as insights emerging from interdisciplinary systems biology approaches to understand this complex phenomenon.
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Cites
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Cited by
Tong, X., Tang, R., Xiao, M., Xu, J., Wang, W., Zhang, B., Liu, J., Yu, X., & Shi, S. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01392-3 · Cited by 883
Small Molecules against Metastatic Tumors: Concrete Perspectives and Shattered Dreams
Serra, M., Rubes, D., Schinelli, S., & Paolillo, M. (2023) · Cancers · doi:10.3390/cancers15164173 · Cited by 13
Metadata
- Authors
- Suhail, Y., Cain, M. P., Vanaja, K., Kurywchak, P. A., Levchenko, A., Kalluri, R., & Kshitiz
- Venue
- Cell Systems
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 9
- Issue
- 2
- Pages
- 109-127
- ISSN
- 2405-4712 (ISSN-L)
- OpenAlex
- W2970819265
- Cited by
- 452
- References
- 220
- FWCI
- 13.51
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Suhail, Y., Cain, M. P., Vanaja, K., Kurywchak, P. A., Levchenko, A., Kalluri, R., & Kshitiz. (2019). Systems Biology of Cancer Metastasis. Cell Systems. https://doi.org/10.1016/j.cels.2019.07.003
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
