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Cited by 171Genetic Mapping and Diversity in Plants and AnimalsGenetic Associations and EpidemiologyGenetic and phenotypic traits in livestock

A platform for experimental precision medicine: The extended BXD mouse family

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Ashbrook, David G., Arends, Danny, Prins, Pjotr, Mulligan, Megan K., Roy, Suheeta, Williams, Evan G., Lutz, Cathleen M., Valenzuela, Alicia +8 more·2021·Cell Systems
DOI 10.1016/j.cels.2020.12.002PMC PMC7979527
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Abstract

The challenge of precision medicine is to model complex interactions among DNA variants, phenotypes, development, environments, and treatments. We address this challenge by expanding the BXD family of mice to 140 fully isogenic strains, creating a uniquely powerful model for precision medicine. This family segregates for 6 million common DNA variants-a level that exceeds many human populations. Because each member can be replicated, heritable traits can be mapped with high power and precision. Current BXD phenomes are unsurpassed in coverage and include much omics data and thousands of quantitative traits. BXDs can be extended by a single-generation cross to as many as 19,460 isogenic F1 progeny, and this extended BXD family is an effective platform for testing causal modeling and for predictive validation. BXDs are a unique core resource for the field of experimental precision medicine.

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  • All five parental strains have been deeply sequenced and all F1 hybrids therefore have completely defined genomes.

    “All five of the parental strains have been deeply sequenced and all F1 hybrids therefore have completely defined genomes11,82.”

    From Magnetic resonance microscopy maps widespread effects of Alzheimer’s disease on brain structures and behavior in mice (2026) · cites this paper as [11]

    The Introduction reports full sequence data for both BXD parents, not five parental strains. The Discussion (Future Directions) says that isogenic BXD F1 lines have entirely defined genomes, supporting the genome claim for those hybrids but not the stated five-parent basis. (LLM, conf=0.90)

    Experimental — accuracy not yet measured

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Authors
Ashbrook, D. G., Arends, D., Prins, P., Mulligan, M. K., Roy, S., Williams, E. G., Lutz, C. M., Valenzuela, A., Bohl, C. J., Ingels, J. F., McCarty, M. S., Centeno, A. G., Hager, R., Auwerx, J., Lu, L., & Williams, R. W.
Affiliations
  • University of Tennessee Health Science Center (US)
  • Humboldt-Universität zu Berlin (DE)
  • University of Luxembourg (LU)
  • Jackson Laboratory (US)
  • Manchester Academic Health Science Centre (GB)
  • École Polytechnique Fédérale de Lausanne (CH)
Corresponding author
  • Ashbrook, David G.
  • Lu, Lu
  • Williams, Robert W.
ORCID
Venue
Cell Systems
Publisher
Elsevier BV
Published
2021-03
Volume
12
Issue
3
Pages
235-247.e9
ISSN
2405-4712 (ISSN-L)
DOI
10.1016/j.cels.2020.12.002
PMC
PMC7979527
OpenAlex
W3124980307
Cited by
171
References
156
Citations by year
2026: 15 · 2025: 25 · 2024: 31 · 2023: 46 · 2022: 27 · 2021: 27
FWCI
18.66
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Systems (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (publishedVersion, other-oa)
  • PubMed Central (acceptedVersion)
  • Open Repository and Bibliography (University of Luxembourg) (submittedVersion, other-oa)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
  • The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
Funders
  • European Research Council
  • National Institute on Drug Abuse (P30DA044223)
  • National Institute on Aging (R01AG043930)
  • SystemsX.ch (RTD 2013/153)
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (310030B-160318)
  • National Institute on Alcohol Abuse and Alcoholism (U01 AA016662, U01 AA013499, U01 AA014425)
  • NIH Office of the Director (P40 OD011102)
  • Engineering Research Centers
  • École Polytechnique Fédérale de Lausanne
  • Pennsylvania State University
  • National Institutes of Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
Keywords
BXD mouse strains, precision medicine, quantitative traits, phenome, F1 progeny, causal models, predictive validation, gene mapping, mouse genetic resources
MeSH terms
Animals, Disease Models, Animal, Mice, Precision Medicine

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