Relationship Between Changes in Serum Levels of Keratin 18 and Changes in Liver Histology in Children and Adults With Nonalcoholic Fatty Liver Disease

Vuppalanchi, Raj; Jain, Ajay K.; Deppe, Ross; Yates, Katherine; Comerford, Megan; Masuoka, Howard C.; Neuschwander-Tetri, Brent A.; Loomba, Rohit; Brunt, Elizabeth M.; Kleiner, David E.; Molleston, Jean P.; Schwimmer, Jeffrey B.; Lavine, Joel E.; Tonascia, James; Chalasani, Naga

doi:10.1016/j.cgh.2014.05.010

Relationship Between Changes in Serum Levels of Keratin 18 and Changes in Liver Histology in Children and Adults With Nonalcoholic Fatty Liver Disease

Background & Aims Previous cross-sectional studies have shown that serum keratin 18 (K18) fragment levels predict liver histology in individuals with nonalcoholic fatty liver disease (NAFLD). We conducted a study to examine the relationship between changes in serum K18 levels and changes in liver…