Inter- and Intra-individual Variation, and Limited Prognostic Utility, of Serum Alkaline Phosphatase in a Trial of Patients With Primary Sclerosing Cholangitis

Trivedi, Palak J.; Muir, Andrew J.; Levy, Cynthia; Bowlus, Christopher L.; Manns, Michael P.; Lu, Xiaomin; Crans, Gerald; Chung, Chuhan; Subramanian, G. Mani; Myers, Robert P.; Goodman, Zachary; Chalasani, Naga; Vierling, John M.; Guha, Indra Neil; Hirschfield, Gideon M.

doi:10.1016/j.cgh.2020.07.032

Inter- and Intra-individual Variation, and Limited Prognostic Utility, of Serum Alkaline Phosphatase in a Trial of Patients With Primary Sclerosing Cholangitis

BACKGROUND & AIMS Serum alkaline phosphatase (ALP) and the enhanced liver fibrosis (ELF) score are used as endpoints in trials of patients with primary sclerosing cholangitis (PSC). We aimed to quantify inter- and intra-individual variation in levels of ALP and the ELF score over time, and evalua…