HepQuant SHUNT Detects Portal Hypertension in Early Stages of Clinically Compensated Chronic Liver Disease
Open accessAbstract
Physicians use portal pressure measurements in clinical practice and research but the methods are invasive, can cause complications, and are resource intensive.1-3 Herein we describe preliminary findings of the minimally invasive HepQuant-SHUNT test in the diagnosis of portal hypertension in precirrhotic and compensated cirrhotic patients.
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Emerging technologies assess clearance of a liver-metabolized substrate or release of proteases that reflect ECM degradation in liver.
“In liver, other emerging technologies assess either clearance of a liver-metabolized substrate (303), or release of proteases that reflect ECM degradation in liver (304).”
From Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH) (2023) · cites this paper as [303]
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References 9 · Cited by 23
- Authors
- Wieland, A., Etzion, O., Ali, R. O., Levy, E., Kleiner, D. E., Helmke, S. M., Heller, T., & Everson, G. T.
- Affiliations
- University of Colorado Anschutz (US)
- National Institutes of Health (US)
- National Cancer Institute (US)
- HepQuant (United States) (US)
- Corresponding author
- Everson, Gregory T.
- Venue
- Clinical Gastroenterology and Hepatology
- Publisher
- Elsevier BV
- Published
- 2022-04
- Volume
- 20
- Issue
- 4
- Pages
- e890-e894
- ISSN
- 1542-3565 (ISSN-L)
- PMC
- PMC8531144
- OpenAlex
- W3158114641
- Cited by
- 23
- References
- 9
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 8 · 2023: 4 · 2022: 3 · 2021: 1
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Clinical Gastroenterology and Hepatology (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Colorado
- National Institute of Diabetes and Digestive and Kidney Diseases
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- portal hypertension, compensated cirrhosis, chronic liver disease, non-invasive diagnosis
- MeSH terms
- Humans, Hypertension, Portal, Liver Cirrhosis
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