Puberty and depression
Abstract
Unipolar depression only becomes more common in girls than boys after the age of 13, as a result of an increased incidence of depressive episodes in girls at that time. This article reviews evidence that links multiple dimensions of maturation in the hypothalamo-pituitary-gonadal axis with this phenomenon. Effects of developmental status and timing have been implicated, but few studies have deployed either the measurement strategies or the statistical power needed to provide a satisfactory answer to the question regarding which components of puberty are most responsible.
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This is one of the first studies to test associations between pubertal development and depressive symptoms in this early developmental period, which has been a significant gap in the puberty-depression literature.
“Notwithstanding these limitations, this is one of the first studies to test associations between pubertal development and depressive symptoms in this early developmental period, which has been a significant gap in the puberty–depression literature.43”
From Subthreshold Symptoms of Depression in Preadolescent Girls Are Stable and Predictive of Depressive Disorders (2008) · cites this paper as [43]
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References 181 · Cited by 252
- Authors
- Angold, A., & Costello, E. J.
- Affiliations
- Duke University (US)
- Corresponding author
- Angold, Adrian
- ORCID
- Costello, E. Jane
- Venue
- Child and Adolescent Psychiatric Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2006-10
- Volume
- 15
- Issue
- 4
- Pages
- 919-937
- ISSN
- 1056-4993 (ISSN-L)
- OpenAlex
- W2022528291
- Cited by
- 252
- References
- 181
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 9 · 2023: 8 · 2022: 5 · 2021: 10 · 2020: 9 · 2019: 11 · 2018: 10 · 2017: 15 · 2016: 16 · 2015: 16 · 2014: 16 · 2013: 20 · 2012: 13
- FWCI
- 1.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Child and Adolescent Psychiatric Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- puberty, depression, major depressive disorder, sex differences, hypothalamic-pituitary-gonadal axis, adolescent development, timing of puberty, developmental status
- MeSH terms
- Adolescent, Androgens, Dehydroepiandrosterone, Major Depressive Disorder, Female, Gonadotropins, Humans, Male, Puberty, Surveys and Questionnaires
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