The DOI matches its Crossref record; 41 of the 42 references it cites were found in a registry or an index.
Poly (β-amino ester) s promote cellular uptake of heparin and cancer cell death
Open accessAbstract
Heparin/heparan sulfate-like glycosaminoglycans (HSGAGs) are involved in diverse cellular processes in the extracellular matrix (ECM). The biological effect of HSGAGs depends on disaccharide content and physiological location within the ECM. HSGAGs are also brought into cells during membrane transcytosis and growth factor signaling while protein bound. We sought to probe the impact of free HSGAGs within the cell by using heparin as a model HSGAG. A library of poly(beta-amino ester)s, which internalize DNA, was examined for the capacity of its members to internalize heparin. Fourteen polymers enabled heparin internalization. The most efficacious polymer reduced murine melanoma cell growth by 73%. No glycosaminoglycan was as efficacious as highly sulfated, full-length heparin. Internalized heparin likely interferes with transcription factor function and subsequently induces apoptotic cell death. Therefore, internalized heparin is a novel mechanism for inducing apoptosis of cancer cells.
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“Glycosaminoglycans are sulfated internally and thus induced murine melanoma cell apoptosis by altering transcription [174].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [174]
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Metadata
- Authors
- Berry, D., Lynn, D. M., Sasisekharan, R., & Langer, R.
- Affiliations
- Harvard University (US)
- Massachusetts Institute of Technology (US)
- Harvard–MIT Division of Health Sciences and Technology (US)
- Venue
- Chemistry & Biology
- Publisher
- Elsevier BV
- Published
- 2004-04
- Volume
- 11
- Issue
- 4
- Pages
- 487-498
- ISSN
- 1074-5521 (ISSN-L)
- OpenAlex
- W2052116394
- Cited by
- 56
- References
- 42
- Citations by year
- 2023: 3 · 2020: 2 · 2019: 3 · 2018: 1 · 2016: 3 · 2015: 3 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Chemistry & Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL59966, R01HL059966)
- National Cancer Institute (CA52857)
- National Institute of General Medical Sciences (R01GM026698, GM 26698)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- poly(β-amino ester), heparin, cellular uptake, polymer-drug conjugates, melanoma, apoptosis, transcription factor function, extracellular matrix, cancer cell death
- MeSH terms
- Animals, Biological Transport, Cell Division, Cell Line, DNA, Extracellular Matrix, Glycosaminoglycans, Heparin, Humans, Melanoma, Experimental, Polyesters, Time Factors, Molecular Structure, Cell Death, Heparan Sulfate Proteoglycans, Mice
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