Small molecule activation of PKM2 in cancer cells induces serine auxotrophy
Kung, Charles, Hixon, Jeff, Choe, Sung, Marks, Kevin, Gross, Stefan, Murphy, Erin, DeLaBarre, Byron, Cianchetta, Giovanni +23 more·2012·Chemistry & Biology
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Items 101–194 of 194
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- A Review on the Role of Pyruvate Kinase M2 in Cancer: From Metabolic Switch to Transcriptional RegulationZulfareen, Aaliya Taiyab, Gulam Mustafa Hasan, Md. Imtaiyaz Hassan · 2025 · International Journal of Biological Macromolecules
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- Tumor pyruvate kinase M2: A promising molecular target of gastrointestinal cancerGuo Chen, Li Guan, Jianing Hou, Xingming Deng, Sheng Ao, Zhuofei Li, Guoqing Lyu · 2018 · Chinese Journal of Cancer Research
- Serine and glycine metabolism-related gene expression signature stratifies immune profiles of brain gliomas, and predicts prognosis and responses to immunotherapySiliang Chen, Shuxin Zhang, Wentao Feng, Junhong Li, Yunbo Yuan, Wenhao Li, Zhihao Wang, Yuan Yang, Yanhui Liu · 2022 · Frontiers in Pharmacology
- Allosteric regulation of metabolism in cancer: endogenous mechanisms and considerations for drug designJamie A. Macpherson, Dimitrios Anastasiou · 2017 · Current Opinion in Biotechnology
- Anti‐Warburg effect via generation of ROS and inhibition of PKM2 /β‐catenin mediates apoptosis of lambertianic acid in prostate cancer cellsJi‐Na Pak, Hyo‐Jung Lee, Deok Yong Sim, Ji Eon Park, Chi‐Hoon Ahn, Su‐Yeon Park, Jae‐Ho Khil, Bum‐Sang Shim, Bonglee Kim, Sung‐Hoon Kim · 2023 · Phytotherapy Research
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- AllohubPy: Detecting Allosteric Signals Through An Information-theoretic ApproachOriol Gracia Carmona, Jens Kleinjung, Dimitrios Anastasiou, Chris Oostenbrink, Franca Fraternali · 2025 · Journal of Molecular Biology
- PYK-SubstitutionOME: an integrated database containing allosteric coupling, ligand affinity and mutational, structural, pathological, bioinformatic and computational information about pyruvate kinase isozymesLiskin Swint‐Kruse, Larissa L Dougherty, Braelyn M. Page, Tiffany C. Wu, Pierce T. O’Neil, Charulata B. Prasannan, Cody Timmons, Qingling Tang, Daniel J. Parente, Shwetha Sreenivasan et al. · 2023 · Database
- Roadmap to Pyruvate Kinase M2 Modulation - A Computational ChronicleAmit Shard, Saumya Kapoor, Deep Rohan Chatterjee, Moumita Ghosh Chowdhury, Rudradip Das · 2023 · Current Drug Targets
- Knowledge-driven design and optimization of potent symmetric anticancer molecules: A case study on PKM2 activatorsEshika Jaiswal, Christoph Globisch, Alok K. Jain · 2022 · Computers in Biology and Medicine
- Regulation of glycolysis and cancer cell proliferation by PKM2 citrullinationSébastien Coassolo, Irwin Davidson · 2021 · Molecular & Cellular Oncology
- An evaluation of mitapivat for the treatment of hemolytic anemia in adults with pyruvate kinase deficiencyAndrew B. Song, Hanny T. Al-Samkari · 2022 · Expert Review of Hematology
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- Domesticating Cancer: An Evolutionary Strategy in the War on CancerG. van Niekerk, T. Nell, A. Engelbrecht · 2017 · Frontiers in Oncology
- Glucose Metabolism and Carcinogenesis: The Impact of the Tumor Suppressor p53Monde McMillan Ntwasa, Ubanako Njende · 2018 · InTech eBooks
- Metabolic Reprogramming and Molecular Rewiring in Cancer: Therapeutic OpportunitiesAnna Meiliana, Nurrani Mustika Dewi, Andi Wijaya · 2021 · The Indonesian Biomedical Journal
- Integrated screening for small molecules interfering with PKM2: a drug repurposing strategy against glioblastomaSusan Costantini, Isabella Romeo, Giulia Fanelli, Maria Serena Roca, Gianmarco Gualtieri, Palmina Bagnara, Andrea Polo, Elena Di Gennaro, Francesco Ortuso, Stefano Alcaro et al. · 2025 · Journal of Translational Medicine
- Exploring data‐driven chemical SMILES tokenization approaches to identify key protein–ligand binding moietiesAsu Büşra Temizer, Gökçe Uludoğan, Rıza Özçelik, Taha Koulani, Elif Özkırımlı, Kutlu Ö. Ülgen, Nilgün Karalı, Arzucan Özgür · 2024 · Molecular Informatics
- Phosphine‐Catalyzed 1,6‐Addition and Tandem Addition/Self‐Aldol Condensation Reactions of Para‐Quinone Methides with ThiolsYuan Zhong, Guichen Li, Dan Zhang, Yuxuan Xie, Long Hao, Zhengjun Cai, Xin Wang · 2024 · European Journal of Organic Chemistry
- Selecting the Right Targets for Fragment‐Based Drug DiscoveryThomas G. Davies, Harren Jhoti, Puja Pathuri, Glyn Williams · 2016 · Methods and principles in medicinal chemistry
- ICBS2012 Catalyzes Robust Response from Global Chemical Biology CommunityMargaret A. Johns · 2012 · ACS Chemical Biology
- Mitapivat: New dawn in pyruvate kinase deficiency and beyondRitika Khurana, Sangeeta Sanjay Mudaliar · 2024 · Pediatric Hematology Oncology Journal
- Cancer Metabolism: A Nexus of Matter, Energy, and Reactive Oxygen SpeciesPaul M. Bingham, Shawn D. Stuart, Zuzana Zachar · 2014 · Cancer drug discovery and develogment/Cancer drug discovery and development
- Virtual high-throughput screens identifying hPK-M2 inhibitors: Exploration of model extrapolationJonathan Jun Feng Chen, Lyndsey N. Schmucker, Donald P. Visco · 2018 · Computational Biology and Chemistry
- Molecular docking analysis of pyruvate kinase M2 with a potential inhibitor from the ZINC databasePankaj V. Sharma · 2021 · Bioinformation
- Case studies in rare disease small molecule discovery and developmentDarby R. Schmidt, Christopher Vaun Thompson · 2020 · Bioorganic & Medicinal Chemistry Letters
- Metabolism‐Regulating Nanomedicines for Cancer TherapyXiao Wu, Shiyi Geng, Jian Yu Yang · 2025 · Advanced NanoBiomed Research
- Discovery of 8-quinolinesulfonamide phenylimidazole-based PKM2 agonists for the prevention and delay of aortic dissectionJunda Li, Yanyan Yang, Lei Cheng, Xu Xu, Ke Zhong, Tao Wang, Kailin Chen, Chi Zhang, Chen He, Jinyi Xu et al. · 2025 · European Journal of Medicinal Chemistry
- Evaluation of Anticancer Activity of Novel Sulfanyl-Substituted Hydrazone Compounds in Hepatocellular Carcinoma: In Vitro, In Silico, and In Ovo StudiesHatice Başpınar Küçük, Tülay Yıldız, Yaren ARASAN, Buse Meriç AÇAR, Duygu KURTOĞLU, Aslı Kutlu, Remzi Okan Akar, Sinem KILIÇ, Demet GÜL ERYILMAZ, Engin ULUKAYA · 2026 · ACS Omega
- In SilicoInvestigation of Potential Pyruvate Kinase M2 Regulators from Traditional Chinese Medicine against CancersKuan‐Chung Chen, Kuen‐Bao Chen, Hsin‐Yi Chen, Calvin Yu‐Chian Chen · 2014 · BioMed Research International
- [Advances in Research on Cell Metabolic Interactions in the Tumor Microenvironment].Pengfei Wu, Zhi Yang, Qingyan Li, Denian Wang · 2024 · PubMed Central
- The potential roles of PKM2 in cerebrovascular diseasesLing Ma, H.C. Li, Hu Xu, Dianwei Liu · 2024 · International Immunopharmacology
- Small-Molecule Reprogramming of Cancer MetabolismMatthew R. Pratt · 2012 · Chemistry & Biology
- Local effects of Linoorbitides and enterolactone On intestinal epithelial functionsAhmed A. Almousa · 2017 · University Library - University of Saskatchewan (University of Saskatchewan)
- Mitapivat: a step forward across different hemolytic diseasesMohammad Hassan Hodroj, Joseph Klim, Nicole Charbel, Ali T. Taher · 2025 · Expert Opinion on Emerging Drugs
- The Role of NPM-ALK Signaling in Tumor Cell Metabolism.Scott McDonnell · 2013 · Deep Blue (University of Michigan)
- Abstract 1858: Development of a multiplex panel of biomarkers to assess energy metabolism in cancer.Meenakshi P. Balakrishnan, Ralph E. Parchment, Melinda G. Hollingshead, Joseph E. Tomaszewski, Robert J. Kinders, James H. Doroshow, Apurva K. Srivastava · 2013 · Cancer Research
- Study of regulatory mechanisms of glycolytic and gluconeogenic enzymesMeng Yuan · 2016 · Edinburgh Research Archive (University of Edinburgh)
- Functional consequence of PSAT1 association on PKM2's inherent enzymatic activity.Alexis A. Vega · 2018
- Investigating a novel function for phosphoserine aminotransferase 1 (PSAT1) in epidermal growth factor receptor (EGFR)-mediated lung tumorigenesis.Rumeysa Biyik‐Sit · 2021
- Faculty Opinions recommendation of Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction.Fan Fan Hou, Jing Nie · 2017 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Data from ASO-Based PKM Splice-Switching Therapy Inhibits Hepatocellular Carcinoma GrowthWai Kit Ma, Dillon M. Voss, Juergen Scharner, Ana S.H. Costa, Kuan‐Ting Lin, Hyun Yong Jeon, John Erby Wilkinson, Michaela Jackson, Frank Rigo, C. Frank Bennett et al. · 2023
- Arginine-depleting Enzymes, A Potential Treatment Option for Tumors With Arginine Auxotrophy : A ReviewNurhanis Syafiqah Mohd Nor Hamin, Kok Chang Lee, Wen‐Nee Tan, Woei Yenn Tong, Chean Ring Leong · 2023 · Malaysian Journal of Medicine and Health Sciences
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- Mitapivat (AG-348): a groundbreaking treatment paradigm for pyruvate kinase deficiency and beyondLaiba Shakeel, Rabbia Munsab, Hassan ul Hussain, Aymar Akilimali · 2024 · International Journal of Surgery Global Health
- Allohubpy: Detecting Allosteric Signals Through an Information Theoric ApproachFranca Fraternali, Oriol Gracia Carmona, Jens Kleinjung, Dimitrios Anastasiou, Chris Oostenbrink · 2024 · SSRN Electronic Journal
- Mitapivat: A Novel Drug Discovery for the Treatment of Hereditary Hemolytic AnaemiasShikha Sharma, Utkarsh Sharma · 2025 · Current Indian Science
- Research Progress on the Role of PKM2 in the Cell Cycle of Tumor Cells and Immune CellsYue Lang · 2025 · Advances in Life Science for Adolescents
- Additional file 1 of Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cellsFadi Almouhanna, Biljana Blagojevic, Suzan Can, Ali Ghanem, Stefan Wölfl · 2021 · Figshare
- Additional file 3 of Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cellsFadi Almouhanna, Biljana Blagojevic, Suzan Can, Ali Ghanem, Stefan Wölfl · 2021 · Figshare
- Additional file 2 of Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cellsFadi Almouhanna, Biljana Blagojevic, Suzan Can, Ali Ghanem, Stefan Wölfl · 2021 · Figshare
- Additional file 4 of Pharmacological activation of pyruvate kinase M2 reprograms glycolysis leading to TXNIP depletion and AMPK activation in breast cancer cellsFadi Almouhanna, Biljana Blagojevic, Suzan Can, Ali Ghanem, Stefan Wölfl · 2021 · Figshare
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- BindingDB Entry 50016842: A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2.BindingDB · 2023 · UC San Diego
- BindingDB Entry 50022202: A comprehensive review of new small molecule drugs approved by the FDA in 2022: Advance and prospect.BindingDB · 2025 · UC San Diego
- BindingDB Entry 50046285: An update on therapeutic opportunities offered by cancer glycolytic metabolism.BindingDB · 2016 · UC San Diego
- BindingDB Entry 50003593: Tumor pyruvate kinase M2 modulators: a comprehensive account of activators and inhibitors as anticancer agents.BindingDB · 2024 · UC San Diego
- BindingDB Entry 50019576: Tuning liver pyruvate kinase activity up or down with a new class of allosteric modulators.BindingDB · 2024 · UC San Diego
- BindingDB Entry 50019829: PKM2/PDK1 dual-targeted shikonin derivatives restore the sensitivity of EGFR-mutated NSCLC cells to gefitinib by remodeling glucose metabolism.BindingDB · 2024 · UC San Diego
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