The DOI matches its Crossref record; 106 of the 111 references it cites were found in a registry or an index.
Haven't got a glue: Protein surface variation for the design of molecular glue degraders
Open accessAbstract
Molecular glue degraders are small, drug-like compounds that induce interactions between an E3 ubiquitin ligase and a target, which result in ubiquitination and subsequent degradation of the recruited protein. In recent years, serendipitous discoveries revealed that some preclinical and clinical compounds already work as molecular glue degraders, with many more postulated to destabilize their targets through indirect or yet unresolved mechanisms. Here we review strategies by which E3 ubiquitin ligases can be reprogrammed by monovalent degraders, with a focus on molecular glues hijacking cullin-RING ubiquitin ligases. We argue that such drugs exploit the intrinsic property of proteins to form higher-order assemblies, a phenomenon previously seen with disease-causing sequence variations. Modifications of the protein surface by a bound small molecule can change the interactome of the target protein. By inducing interactions between a ligase and a substrate, molecular glue degraders offer an exciting path for the development of novel therapeutics.
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“Currently, there is no well-established computational framework to predict and evaluate compound-induced PPIs.251”
From Advancing Targeted Protein Degradation via Multiomics Profiling and Artificial Intelligence (2023) · cites this paper as [251]
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Metadata
- Authors
- Kozicka, Z., & Thomä, N. H.
- Affiliations
- University of Basel (CH)
- Friedrich Miescher Institute (CH)
- Corresponding author
- Thomä, Nicolas Holger
- Venue
- Cell Chemical Biology
- Publisher
- Elsevier BV
- Published
- 2021-07
- Volume
- 28
- Issue
- 7
- Pages
- 1032-1047
- ISSN
- 2451-9448 (ISSN-L)
- 2451-9456
- OpenAlex
- W3158527646
- Semantic Scholar
- ae8a5b956b209af205f68e27236708f9dc194e10
- Cited by
- 170
- References
- 111
- Citations by year
- 2026: 37 · 2025: 40 · 2024: 28 · 2023: 34 · 2022: 29 · 2021: 2
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 379 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell chemical biology (publishedVersion)
- PubMed (publishedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion)
- Funders
- European Research Council (666068)
- European Commission (765445)
- Horizon 2020
- Novartis Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (186230, KFS-4980-02-2020)
- Oncosuisse
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Physical Sciences › Chemistry › Organic Chemistry › Chemical Synthesis and Analysis
- Keywords
- molecular glues, E3 ubiquitin ligase, cullin-RING ubiquitin ligases, protein degradation, protein surface modification, protein-protein interaction, protein assembly, drug design, protein-protein interaction network
- MeSH terms
- Enzyme Inhibitors, Humans, Ubiquitin-Protein Ligases, Small Molecule Libraries, Ubiquitination
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