The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
HIV-1 Accessory Proteins—Ensuring Viral Survival in a Hostile Environment
Open accessAbstract
One of the features of primate immunodeficiency viruses (HIVs and SIVs) that distinguishes them from other retroviruses is the array of "accessory" proteins they encode. Here, we discuss recent advances in understanding the interactions of the HIV-1 Nef, Vif, Vpu, and Vpr proteins with factors and pathways expressed in cells of the immune system. In at least three instances, the principal activity of the accessory proteins appears to be evasion from various forms of cell-mediated (or intrinsic), antiviral resistance. Broadly speaking, the HIV-1 accessory proteins modify the local environment within infected cells to ensure viral persistence, replication, dissemination, and transmission.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Function and regulation of cullin–RING ubiquitin ligases
Petroski, M. D., & Deshaies, R. J. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1547 · Cited by 2,148
Identification of host proteins required for HIV infection through a functional genomic screen
Brass, A. L., Dykxhoorn, D. M., Benita, Y., Yan, N., Engelman, A., Xavier, R. J., Lieberman, J., & Elledge, S. J. (2008) · Science · doi:10.1126/science.1152725 · Cited by 1,449 · cited 4×
“Interestingly, DCAF1 was also identified as an HIV-1-dependency factor (i.e., a protein whose expression promotes replication) in a large-scale siRNA screen using a viral strain that was deficient for Vpr (Brass et al., 2008).”
BackgroundInfluentialAncient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G
Sawyer, S. L., Emerman, M., & Malik, H. S. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020275 · Cited by 485
Self-citationSrivastava, S., Swanson, S. K., Manel, N., Florens, L., Washburn, M. P., & Skowronski, J. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000059 · Cited by 209
HIV-1 Vpr-Mediated G2 Arrest Involves the DDB1-CUL4AVPRBP E3 Ubiquitin Ligase
Belzile, J.-P., Duisit, G., Rougeau, N., Mercier, J., Finzi, A., & Cohen, É. A. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030085 · Cited by 189
HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1
Schröfelbauer, B., Hakata, Y., & Landau, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610167104 · Cited by 187
HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system
DeHart, J. L., Zimmerman, E. S., Ardon, O., Monteiro-Filho, C. M., Argañaraz, E. R., & Planelles, V. (2007) · Virology Journal · doi:10.1186/1743-422x-4-57 · Cited by 152
Cited by
Origins of HIV and the AIDS Pandemic
Sharp, P. M., & Hahn, B. H. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006841 · Cited by 1,496
Global landscape of HIV–human protein complexes
Jäger, S., Cimermancic, P., Gulbahce, N., Johnson, J. R., McGovern, K. E., Clarke, S. C., Shales, M., Mercenne, G., Pache, L., Li, K., et al. (2012) · Nature · doi:10.1038/nature10719 · Cited by 731
Rules of engagement: molecular insights from host–virus arms races
Daugherty, M. D., & Malik, H. S. (2012) · Annual Review of Genetics · doi:10.1146/annurev-genet-110711-155522 · Cited by 515
The IFITM Proteins Inhibit HIV-1 Infection
Lu, J., Pan, Q., Rong, L., Liu, S.-L., & Liang, C. (2011) · Journal of Virology · doi:10.1128/jvi.01531-10 · Cited by 417
Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS
Drexler, J. F., Corman, V. M., & Drosten, C. (2014) · Antiviral Research · doi:10.1016/j.antiviral.2013.10.013 · Cited by 406
Metadata
- Authors
- Malim, M. H., & Emerman, M.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 3
- Issue
- 6
- Pages
- 388-398
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2029930485
- Cited by
- 551
- References
- 7
- FWCI
- 21.30
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: HIV-1 Accessory Proteins—Ensuring Viral Survival in a Hostile Environment. https://app.cochat.ai/papers/10.1016/j.chom.2008.04.008
- The paper
- Malim, M. H., & Emerman, M. (2008). HIV-1 Accessory Proteins—Ensuring Viral Survival in a Hostile Environment. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2008.04.008
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
