The IL-8 Protease SpyCEP/ScpC of Group A Streptococcus Promotes Resistance to Neutrophil Killing

Zinkernagel, Annelies S., Timmer, Anjuli M., Pence, Morgan A., Locke, Jeffrey B., Buchanan, John T., Turner, Claire E., Mishalian, Inbal, Sriskandan, Shiranee, Hanski, Emanuel, Nizet, Victor·2008·Cell Host & Microbe
DOI 10.1016/j.chom.2008.07.002

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  50. Cell Envelope Proteinase A (Streptococcus)
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  53. Epidemiologia zakażeń Streptococcus pyogenes, struktura klonalna populacji i antybiotykooporność
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  55. Host–Pathogen Relationship in Skin and Soft Tissue Infections Caused by Group AstreptococcusandStaphylococcus aureus
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  56. A Farewell to Arms: Streptococcal Strategies to Cope with Innate Immunity
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  57. A requirement for neutrophil glycosaminoglycans in chemokine:receptor interactions is revealed by the streptococcal protease SpyCEP
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  60. Clinical and pathophysiological aspects of sepsis
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  61. Role of complement proteases in Streptococcus pathogenesis in fish
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  62. Immune defence mechanisms of barramundi (Lates calcarifer) peripheral blood against Streptococci
    Kelly‐Anne Masterman · 2016 · The University of Queensland
  63. Establishing the Streptococcus pyogenes model of infection in the zebrafish embryo.
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  65. Initiation of invasive disease in M1T1 group A streptococcus
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  66. Biologia Cellulare, Molecolare e Industriale
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  67. Interaction of Group A Streptococcus and the plasminogen activation system in invasive disease
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  68. Streptococcal immunoglobulin degrading enzymes of the IdeS and IgdE family
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  69. Development of in vitro and in vivo models to characterize biofilm formation by a necrotizing strain of Group A Streptococcus
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  70. Identification and Characterization of Molecular Correlates of Disease in Invasive Streptococcus and Staphylococcus Infection Models
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  71. Systems Biology Approach to Identifying Host Interactive Pathways Modulating the Severity of Streptococcal Sepsis
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