The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly Sites
Open accessAbstract
Positive-strand RNA viruses are known to rearrange cellular membranes to facilitate viral genome replication. The biogenesis and three-dimensional organization of these membranes and the link between replication and virus assembly sites is not fully clear. Using electron microscopy, we find Dengue virus (DENV)-induced vesicles, convoluted membranes, and virus particles to be endoplasmic reticulum (ER)-derived, and we detect double-stranded RNA, a presumed marker of RNA replication, inside virus-induced vesicles. Electron tomography (ET) shows DENV-induced membrane structures to be part of one ER-derived network. Furthermore, ET reveals vesicle pores that could enable release of newly synthesized viral RNA and reveals budding of DENV particles on ER membranes directly apposed to vesicle pores. Thus, DENV modifies ER membrane structure to promote replication and efficient encapsidation of the genome into progeny virus. This architecture of DENV replication and assembly sites could explain the coordination of distinct steps of the flavivirus replication cycle.
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Cites
The Hdj‐2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis
Meacham, G. C., Lu, Z., King, S., Sorscher, E., Tousson, A., & Cyr, D. M. (1999) · The EMBO Journal · doi:10.1093/emboj/18.6.1492 · Cited by 335
Cited by
Dengue Virus Capsid Protein Usurps Lipid Droplets for Viral Particle Formation
Samsa, M. M., Mondotte, J. A., Iglesias, N. G., Assunção-Miranda, I., Barbosa-Lima, G., Da Poian, A. T., Bozza, P. T., & Gamarnik, A. V. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000632 · Cited by 586
Heaton, N. S., Perera, R., Berger, K. L., Khadka, S., LaCount, D. J., Kuhn, R. J., & Randall, G. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010811107 · Cited by 566
Snijder, E. J., Limpens, R. W. A. L., de Wilde, A. H., de Jong, A. W. M., Zevenhoven-Dobbe, J. C., Maier, H. J., Faas, F. F. G. A., Koster, A. J., & Bárcena, M. (2020) · PLOS Biology · doi:10.1371/journal.pbio.3000715 · Cited by 477
Rewiring cellular networks by members of the Flaviviridae family
Neufeldt, C. J., Cortese, M., Acosta, E. G., & Bartenschlager, R. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.170 · Cited by 409
Self-citationUltrastructural Characterization of Zika Virus Replication Factories
Cortese, M., Goellner, S., Acosta, E. G., Neufeldt, C. J., Oleksiuk, O., Lampe, M., Haselmann, U., Funaya, C., Schieber, N., Ronchi, P., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.014 · Cited by 359
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Metadata
- Authors
- Welsch, S., Miller, S., Romero-Brey, I., Merz, A., Bleck, C. K. E., Walther, P., Fuller, S. D., Antony, C., Krijnse-Locker, J., & Bartenschlager, R.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 5
- Issue
- 4
- Pages
- 365-375
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2052214918
- Cited by
- 1,091
- References
- 1
- FWCI
- 48.79
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Welsch, S., Miller, S., Romero-Brey, I., Merz, A., Bleck, C. K. E., Walther, P., Fuller, S. D., Antony, C., Krijnse-Locker, J., & Bartenschlager, R. (2009). Composition and Three-Dimensional Architecture of the Dengue Virus Replication and Assembly Sites. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2009.03.007
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