The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Microbial Colonization Drives Expansion of IL-1 Receptor 1-Expressing and IL-17-Producing γ/δ T Cells
Open accessAbstract
SUMMARY IL-17 cytokine production by the Th17 T-cell subset is regulated by intestinal commmensals. We show microbial colonization also regulates innate IL-17 production. A population of CD62L− γ/δ T cells, in particular a lineage expressing the IL-1 receptor 1 (IL-1R1), can be quickly activated by microbes to produce IL-17. Antibiotic-treatment and monocolonization of mice suggest specific commensals—but not metronidazole-sensitive anaerobes like Bacteroides species—are required for maintaining IL-1R1+ γ/δ T cells. Signaling through the guanine nucleotide exchange factor VAV1 but not through Toll-like receptors or antigen presentation pathways is essential for inducing IL-1R1+ γ/δ T cells. Furthermore, IL-1R1+ γ/δ T cells are a potential source of IL-17 that can be activated by IL-23 and IL-1 in both infectious and noninfectious settings in vitro and in vivo. Thus, commensals orchestrate the expansion of phenotypically distinct γδ T cells and innate immunity is a three-way interaction between host, pathogens and microbiota.
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Cites
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910
Self-citationA microbial symbiosis factor prevents intestinal inflammatory disease
Mazmanian, S. K., Round, J. L., & Kasper, D. L. (2008) · Nature · doi:10.1038/nature07008 · Cited by 2,340
Self-citationIvanov, I. I., Frutos, R. D. L., Manel, N., Yoshinaga, K., Rifkin, D. B., Sartor, R. B., Finlay, B. B., & Littman, D. R. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.09.009 · Cited by 1,770
ATP drives lamina propria TH17 cell differentiation
Atarashi, K., Nishimura, J., Shima, T., Umesaki, Y., Yamamoto, M., Onoue, M., Yagita, H., Ishii, N., Evans, R., Honda, K., et al. (2008) · Nature · doi:10.1038/nature07240 · Cited by 1,089 · cited 2×
“…expands the population of CD4+ T cells (Macpherson and Harris, 2004), enhances the differentiation of Th17 cells (interleukin 17 [IL-17]producing CD4+ T cells) (Atarashi et al., 2008), and corrects an imbalance among different CD4+ T cell subsets (Mazmanian et al., 2005; Ivanov et al., 2008).”
BackgroundRibot, J. C., deBarros, A., Pang, D. J., Neves, J. F., Peperzak, V., Roberts, S. J., Girardi, M., Borst, J., Hayday, A. C., Pennington, D. J., et al. (2009) · Nature Immunology · doi:10.1038/ni.1717 · Cited by 628
Polysaccharide processing and presentation by the MHCII pathway
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Endometriotic disease: the role of peritoneal fluid
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Cited by
The interleukin-1 family: back to the future
Garlanda, C., Dinarello, C. A., & Mantovani, A. (2013) · Immunity · doi:10.1016/j.immuni.2013.11.010 · Cited by 1,945
“However, Tgd17 express the IL-1R and IL-1 in concert with IL-23 drives their activation and IL-1 production, thus setting in motion an amplification circuit (Duan et al., 2010; Zeng et al., 2012).”
Microbiota-mediated colonization resistance against intestinal pathogens
Buffie, C. G., & Pamer, E. G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3535 · Cited by 1,564
Gut immune maturation depends on colonization with a host-specific microbiota
Chung, H., Pamp, S. J., Hill, J. A., Surana, N. K., Edelman, S. M., Troy, E. B., Reading, N. C., Villablanca, E. J., Wang, S., Mora, J. R., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.037 · Cited by 1,241
Self-citationHomeostatic Immunity and the Microbiota
Belkaid, Y., & Harrison, O. J. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.008 · Cited by 1,261
A Symbiotic View of Life: We Have Never Been Individuals
Gilbert, S. F., Sapp, J., & Tauber, A. I. (2012) · The Quarterly Review of Biology · doi:10.1086/668166 · Cited by 1,201
Metadata
- Authors
- Duan, J., Chung, H., Troy, E., & Kasper, D. L.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 7
- Issue
- 2
- Pages
- 140-150
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W1993187510
- Cited by
- 224
- References
- 7
- FWCI
- 6.91
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Duan, J., Chung, H., Troy, E., & Kasper, D. L. (2010). Microbial Colonization Drives Expansion of IL-1 Receptor 1-Expressing and IL-17-Producing γ/δ T Cells. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2010.01.005
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