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Cited by 375Gut microbiota and healthInflammatory Bowel DiseaseIL-33, ST2, and ILC Pathways

Lipocalin 2 protects from inflammation and Tumorigenesis associated with gut microbiota alterations

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Moschen, Alexander R., Gerner, Romana R., Wang, Jun, Klepsch, Victoria, Adolph, Timon E., Reider, Simon J., Hackl, Hubert, Pfister, Alexandra +9 more·2016·Cell Host & Microbe
DOI 10.1016/j.chom.2016.03.007
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Abstract

High mucosal and fecal concentrations of the antimicrobial siderophore-binding peptide Lipocalin-2 (Lcn2) are observed in inflammatory bowel disease. However, Lcn2 function in chronic intestinal inflammation remains unclear. Here, we demonstrate that Lcn2 protects from early-onset colitis and spontaneous emergence of right-sided colonic tumors resulting from IL-10 deficiency. Exacerbated inflammation in Lcn2(-/-)/Il10(-/-) mice is driven by IL-6, which also controls tumorigenesis. Lcn2(-/-)/Il10(-/-) mice exhibit profound alterations in gut microbial composition, which contributes to inflammation and tumorigenesis, as demonstrated by the transmissibility of the phenotype and protection conferred by antibiotics. Specifically, facultative pathogenic Alistipes spp. utilize enterobactin as iron source, bloom in Lcn2(-/-)/Il10(-/-) mice, and are sufficient to induce colitis and right-sided tumors when transferred into Il10(-/-) mice. Our results demonstrate that Lcn2 protects against intestinal inflammation and tumorigenesis associated with alterations in the microbiota.

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Crossref · 10.1016/j.chom.2016.03.007

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  • By binding enterobactin, NGAL maintains the balance between commensal bacteria and immune cells in the gut where colitogenic bacteria can reside and secrete high amounts of enterobactin into the intestinal lumen.

    “In doing so, NGAL maintains the balance between commensal bacteria and immune cells in the gut where colitogenic bacteria can reside and secrete high amounts of enterobactin into the intestinal lumen (Deriu et al., 2013;Moschen et al., 2016;Toyonaga et al., 2016).”

    From Iron in infection and immunity (2020) · cites this paper as Moschen et al., 2016

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References 37 · Cited by 375

Authors
Moschen, A. R., Gerner, R. R., Wang, J., Klepsch, V., Adolph, T. E., Reider, S. J., Hackl, H., Pfister, A., Schilling, J., Moser, P. L., Kempster, S. L., Swidsinski, A., Orth−Höller, D., Weiss, G., Baines, J. F., Kaser, A., & Tilg, H.
Affiliations
  • Innsbruck Medical University (AT)
  • Christian-Albrechts-Universität zu Kiel (DE)
  • Stiftung Charité (DE)
  • University of Cambridge (GB)
Corresponding author
  • Moschen, Alexander R.
  • Tilg, Herbert
ORCID
Venue
Cell Host & Microbe
Publisher
Elsevier BV
Published
2016-04
Volume
19
Issue
4
Pages
455-469
ISSN
1931-3128 (ISSN-L)
DOI
10.1016/j.chom.2016.03.007
OpenAlex
W2339478720
Cited by
375
References
37
Citations by year
2026: 24 · 2025: 40 · 2024: 61 · 2023: 47 · 2022: 52 · 2021: 35 · 2020: 53 · 2019: 23 · 2018: 15 · 2017: 22 · 2016: 2
FWCI
10.74
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Host & Microbe (publishedVersion)
  • PubMed (publishedVersion)
  • Apollo (University of Cambridge) (acceptedVersion, cc-by-nc-nd)
  • Max Planck Digital Library (submittedVersion, other-oa)
  • MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
  • Apollo
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords
neutrophil gelatinase-associated lipocalin, intestinal inflammation, colorectal cancer, gut microbiota, IL-10 deficiency, interleukin-6, enterobactin, Alistipes, siderophores, colitis, mucosal immunity
MeSH terms
Gastrointestinal Microbiome, Lipocalin-2, Animals, Bacteroides, Colitis, Humans, Inflammation, Intestinal Neoplasms, Mice, Inbred C57BL, Interleukin-6, Interleukin-10, Mice, Knockout, Mice, Carcinogenesis

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