IL-17 Receptor Signaling in Oral Epithelial Cells Is Critical for Protection against Oropharyngeal Candidiasis

Conti, Heather R.; Bruno, Vincent M.; Childs, Erin E.; Daugherty, Sean; Hunter, Joseph P.; Mengesha, Bemnet G.; Saevig, Danielle L.; Hendricks, Matthew R.; Coleman, Bianca M.; Brane, Lucas; Solis, Norma; Cruz, J. Agustin; Verma, Akash H.; Garg, Abhishek V.; Hise, Amy G.; Richardson, Jonathan P.; Naglik, Julian R.; Filler, Scott G.; Kolls, Jay K.; Sinha, Satrajit; Gaffen, Sarah L.

doi:10.1016/j.chom.2016.10.001

IL-17 Receptor Signaling in Oral Epithelial Cells Is Critical for Protection against Oropharyngeal Candidiasis

SUMMARY Signaling through the IL-17 receptor (IL-17R) is required to prevent oropharyngeal candidiasis (OPC) in mice and humans. However, the IL-17-responsive cell type(s) that mediate protection are unknown. Using radiation chimeras we were able to rule out a requirement for IL-17RA in the hemat…