The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
A Comprehensive Subcellular Atlas of the Toxoplasma Proteome via hyperLOPIT Provides Spatial Context for Protein Functions
Open accessAbstract
Apicomplexan parasites cause major human disease and food insecurity. They owe their considerable success to highly specialized cell compartments and structures. These adaptations drive their recognition, nondestructive penetration, and elaborate reengineering of the host's cells to promote their growth, dissemination, and the countering of host defenses. The evolution of unique apicomplexan cellular compartments is concomitant with vast proteomic novelty. Consequently, half of apicomplexan proteins are unique and uncharacterized. Here, we determine the steady-state subcellular location of thousands of proteins simultaneously within the globally prevalent apicomplexan parasite Toxoplasma gondii. This provides unprecedented comprehensive molecular definition of these unicellular eukaryotes and their specialized compartments, and these data reveal the spatial organizations of protein expression and function, adaptation to hosts, and the underlying evolutionary trajectories of these pathogens.
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Cited by
Conoid extrusion regulates glideosome assembly to control motility and invasion in Apicomplexa
Dos Santos Pacheco, N., Brusini, L., Haase, R., Tosetti, N., Maco, B., Brochet, M., Vadas, O., & Soldati-Favre, D. (2022) · Nature Microbiology · doi:10.1038/s41564-022-01212-x · Cited by 46
Moen, K. E., & Moreno, S. N. J. (2026) · mBio · doi:10.1128/mbio.03124-25
Metadata
- Authors
- Barylyuk, K., Koreny, L., Ke, H., Butterworth, S., Crook, O. M., Lassadi, I., Gupta, V., Tromer, E., Mourier, T., Stevens, T. J., Breckels, L. M., Pain, A., Lilley, K. S., & Waller, R. F.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2020-11
- Volume
- 28
- Issue
- 5
- Pages
- 752-766.e9
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W3093371308
- Cited by
- 339
- References
- 78
- FWCI
- 29.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Barylyuk, K., Koreny, L., Ke, H., Butterworth, S., Crook, O. M., Lassadi, I., Gupta, V., Tromer, E., Mourier, T., Stevens, T. J., Breckels, L. M., Pain, A., Lilley, K. S., & Waller, R. F. (2020). A Comprehensive Subcellular Atlas of the Toxoplasma Proteome via hyperLOPIT Provides Spatial Context for Protein Functions. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2020.09.011
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
