Infection- and vaccine-induced antibody binding and neutralization of the B.1.351 SARS-CoV-2 variant
Open accessAbstract
The emergence of SARS-CoV-2 variants with mutations in the spike protein is raising concerns about the efficacy of infection- or vaccine-induced antibodies. We compared antibody binding and live virus neutralization of sera from naturally infected and Moderna-vaccinated individuals against two SARS-CoV-2 variants: B.1 containing the spike mutation D614G and the emerging B.1.351 variant containing additional spike mutations and deletions. Sera from acutely infected and convalescent COVID-19 patients exhibited a 3-fold reduction in binding antibody titers to the B.1.351 variant receptor-binding domain of the spike protein and a 3.5-fold reduction in neutralizing antibody titers against SARS-CoV-2 B.1.351 variant compared to the B.1 variant. Similar results were seen with sera from Moderna-vaccinated individuals. Despite reduced antibody titers against the B.1.351 variant, sera from infected and vaccinated individuals containing polyclonal antibodies to the spike protein could still neutralize SARS-CoV-2 B.1.351, suggesting that protective humoral immunity may be retained against this variant.
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Most prior studies evaluated sera from vaccinated individuals soon after the first or second dose and had limited data on the durability of such responses.
“Most of these prior studies have evaluated sera from vaccinated individuals at time points soon after the first or second dose and have had limited data on the durability of such responses.”
From Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants (2021) · cites this paper as [2]
B.1.351 was the most resistant to neutralization by convalescent or vaccinee sera, with 6- to 15-fold less neutralization activity for sera from individuals immunized with vaccines based on the WA1 strain.
“In multiple studies, B.1.351 was the most resistant to neutralization by convalescent or vaccinee sera, with 6- to 15-fold less neutralization activity for sera from individuals immunized with vaccines based on the virus strain first described in January 2020 (Wuhan-Hu-1, spike also called WA1) (2–9).”
From Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants (2021) · cites this paper as [2]
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References 42 · Cited by 224
- Authors
- Edara, V. V., Norwood, C., Floyd, K., Lai, L., Davis-Gardner, M. E., Hudson, W. H., Mantus, G., Nyhoff, L. E., Adelman, M. W., Fineman, R., Patel, S., Byram, R., Gomes, D. N., Michael, G., Abdullahi, H., Beydoun, N., Panganiban, B., McNair, N., Hellmeister, K., Pitts, J., Winters, J., Kleinhenz, J., Usher, J., O’Keefe, J. B., Piantadosi, A., Waggoner, J. J., Babiker, A., Stephens, D. S., Anderson, E. J., Edupuganti, S., Rouphael, N., Ahmed, R., Wrammert, J., & Suthar, M. S.
- Affiliations
- Emory University (US)
- Corresponding author
- Wrammert, Jens
- Suthar, Mehul S.
- ORCID
- Edara, Venkata Viswanadh
- Norwood, Carson
- Floyd, Katharine
- Lai, Lilin
- Davis-Gardner, Meredith E.
- Mantus, Grace
- Nyhoff, Lindsay E.
- Adelman, Max W.
- Byram, Rebecca
- Beydoun, Nour
- O’Keefe, James B.
- Piantadosi, Anne
- Waggoner, Jesse J.
- Babiker, Ahmed
- Stephens, David S.
- Anderson, Evan J.
- Edupuganti, Srilatha
- Rouphael, Nadine
- Ahmed, Rafi
- Wrammert, Jens
- Suthar, Mehul S.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2021-04
- Volume
- 29
- Issue
- 4
- Pages
- 516-521.e3
- ISSN
- 1931-3128 (ISSN-L)
- PMC
- PMC7980225
- OpenAlex
- W3139161083
- Cited by
- 224
- References
- 42
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 18 · 2023: 19 · 2022: 85 · 2021: 87
- FWCI
- 16.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 378 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell Host & Microbe (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Keywords
- SARS-CoV-2, B.1.351 variant, Omicron variant, spike protein mutations, antibody binding, neutralizing antibodies, Moderna vaccine, humoral immunity, receptor binding domain, vaccine-induced antibodies, natural infection
- MeSH terms
- COVID-19, SARS-CoV-2, COVID-19 Vaccines, Antibodies, Viral, Binding Sites, Humans, Neutralization Tests, Receptors, Virus, Antibodies, Neutralizing
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