The resistance within: antibiotic disruption of the gut microbiome and resistome dynamics in infancy
Open accessAbstract
Intestinal host-microbiota interactions during the first year of life are critical for infant development. Early-life antibiotic exposures disrupt stereotypical gut microbiota maturation and adversely affect childhood health. Furthermore, antibiotics increase the abundance of resistant bacteria and enrich the resistome-the compendium of antibiotic resistance genes-within the gut microbiota. Here, we discuss acute and persistent impacts of antibiotic exposure during infancy on pediatric health, the gut microbiome, and, particularly, the resistome. Reviewing our current understanding of antibiotic resistance acquisition and dissemination within and between microbiomes, we highlight open questions, which are imperative to resolve in the face of rising bacterial resistance.
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Early-life antibiotic exposure appears to disrupt microbiota colonization and maturation, resulting in adverse child health outcomes.
“Early-life antibiotic exposure, therefore, appears to disrupt microbiota colonization and maturation, resulting in adverse child health outcomes (413).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [413]
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References 64 · Cited by 76
- Authors
- Thänert, R., Sawhney, S. S., Schwartz, D. J., & Dantas, G.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Dantas, Gautam
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2022-05
- Volume
- 30
- Issue
- 5
- Pages
- 675-683
- ISSN
- 1931-3128 (ISSN-L)
- PMC
- PMC9173668
- OpenAlex
- W4280532534
- Cited by
- 76
- References
- 64
- Citations by year
- 2026: 14 · 2025: 25 · 2024: 18 · 2023: 15 · 2022: 4
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 375 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell Host & Microbe (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Thrasher Research Fund
- Doris Duke Charitable Foundation
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (K08 AI1593834, R01AI155893)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD092414)
- National Institute of General Medical Sciences (T32GM007067, 2021081)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
- Keywords
- antibiotic exposure, infant gut microbiota, resistome, antibiotic resistance genes, early-life antibiotic exposure, microbiota maturation, host-microbiota interactions, child health, horizontal gene transfer
- MeSH terms
- Gastrointestinal Microbiome, Anti-Bacterial Agents, Bacteria, Child, Drug Resistance, Microbial, Humans, Infant, Microbiota
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