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Determination of the Alternaria mycotoxin tenuazonic acid in cereals by high-performance liquid chromatography–electrospray ionization ion-trap multistage mass spectrometry after derivatization with 2,4-dinitrophenylhydrazine
Abstract
Tenuazonic acid (TA) is a major Alternaria mycotoxin. In the present work a novel approach for the detection of TA in cereals by liquid chromatography-ion-trap multistage mass spectrometry after derivatization with 2,4-dinitrophenylhydrazine is described. The product of the derivatization reaction and its major MS(2) fragments were characterised by Fourier transform-ion cyclotron resonance tandem mass spectrometry. Without preconcentration, the established method features a limit of detection of 10 microg/kg using 2g of sample in a rapid workup procedure. Accuracy, precision and linearity were evaluated in the working range of 50-5000 microg/kg. TA was detected in 13 and quantified in 3 out of 27 cereal samples obtained from a local supermarket, the average content being 49 microg/kg (highest incidence: 851+/-41 microg/kg).
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“Chemical labelling has become a widely employed approach not only in the NPs research, but also in other research fields including proteomics,98,99 food-safety,100,101 forensics,102,103 environmental analysis.104,105”
From Connecting metabolome and phenotype: recent advances in functional metabolomics tools for the identification of bioactive natural products (2024) · cites this paper as [101]
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References 48 · Cited by 86
Research works printed but not linked: 1
- U. Kocher, W. Schick, I. Wohlhüter, presented at the 30th Mycotoxin Workshop 2008, Society of Mycotoxin Research, Utrecht, Netherlands, 28–30.04.2008.
Metadata
- Authors
- Siegel, D., Rasenko, T., Koch, M., & Nehls, I.
- Affiliations
- Federal Institute For Materials Research and Testing (DE)
- Corresponding author
- Siegel, David
- ORCID
- Koch, Matthias
- Venue
- Journal of Chromatography A
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 1216
- Issue
- 21
- Pages
- 4582-4588
- ISSN
- 0021-9673 (ISSN-L)
- OpenAlex
- W2031157104
- Cited by
- 86
- References
- 48
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 9 · 2020: 5 · 2019: 4 · 2018: 3 · 2017: 12 · 2016: 6 · 2015: 6 · 2014: 3 · 2013: 7 · 2012: 6
- FWCI
- 8.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Chromatography A (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bundesanstalt für Materialforschung und -Prüfung
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Mycotoxins in Agriculture and Food
- Life Sciences › Agricultural and Biological Sciences › Food Science › Pesticide Residue Analysis and Safety
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
- Keywords
- tenuazonic acid, Alternaria mycotoxins, cereals, 2,4-dinitrophenylhydrazine derivatization, LC-MS/MS detection, mycotoxin quantification, food contamination
- MeSH terms
- Alternaria, Edible Grain, Chromatography, High Pressure Liquid, Hydrazones, Phenylhydrazines, Reference Standards, Tenuazonic Acid, Reproducibility of Results, Spectrometry, Mass, Electrospray Ionization
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- CoChat. (2026). Citation check: Determination of the Alternaria mycotoxin tenuazonic acid in cereals by high-performance liquid chromatography–electrospray ionization ion-trap multistage mass spectrometry after derivatization with 2,4-dinitrophenylhydrazine. https://app.cochat.ai/papers/10.1016/j.chroma.2009.03.063
- The paper
- Siegel, D., Rasenko, T., Koch, M., & Nehls, I. (2009). Determination of the Alternaria mycotoxin tenuazonic acid in cereals by high-performance liquid chromatography–electrospray ionization ion-trap multistage mass spectrometry after derivatization with 2,4-dinitrophenylhydrazine. Journal of Chromatography A. https://doi.org/10.1016/j.chroma.2009.03.063
