Are Deep Eutectic Solvents Useful in Chromatography? A Short Review
Abstract
A literature update has been done concerning Deep Eutectic Solvents (DES) use in chromatography applications. The literature survey was based on the period from 2010 till 2020 and manuscripts reported in the data bases Web of Science and Scopus. The use of DES as mobile phase and mobile phase additives, stationary phases and solid phase modifiers and the use of DES as reaction solvents for chromatography use, were evaluated. Emphasis was placed on the differentiation of DES and Ionic Liquids (ILs) and the advanced green characteristics of the new solvents as compared with traditional organic solvents and ILs with a look into the drawbacks and future perspectives in the field of separation methods.
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Integration of DES extraction with chromatographic and spectrometric techniques through automated and online systems has significantly improved analytical performance.
“The integration of deep eutectic solvent (DES) extraction with chromatographic and spectrometric techniques through automated and online systems has significantly improved analytical performance [121].”
From Eco-Friendly Deep Eutectic Solvent-Based Extraction Technologies: A Comprehensive Review of Principles, Applications, and Comparative Insights (2026) · cites this paper as [121]
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References 73 · Cited by 51
- Authors
- Płotka-Wasylka, J., Rutkowska, M., & de la Guardia, M.
- Affiliations
- Gdańsk University of Technology (PL)
- Venue
- Journal of Chromatography A
- Publisher
- Elsevier BV
- Published
- 2021-02
- Volume
- 1639
- Pages
- 461918
- ISSN
- 0021-9673 (ISSN-L)
- OpenAlex
- W3123369094
- Cited by
- 51
- References
- 73
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 9 · 2023: 6 · 2022: 15 · 2021: 3
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Journal of Chromatography A (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemical Engineering › Catalysis › Ionic liquids properties and applications
- Physical Sciences › Chemistry › Spectroscopy › Analytical Chemistry and Chromatography
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical chemistry methods development
- Keywords
- deep eutectic solvents, chromatography, mobile phase additives, stationary phase, reaction solvents, ionic liquids, green solvents, separation processes
- MeSH terms
- Chromatography, Solvents, Ionic Liquids
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