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Cited by 33Cardiac Imaging and DiagnosticsCardiomyopathy and Myosin StudiesAdvanced MRI Techniques and Applications

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The Prognostic Role of Late Gadolinium Enhancement Magnetic Resonance Imaging in Patients With Cardiomyopathy

Stirrat, John, White, James A.·2013·Canadian Journal of Cardiology
DOI 10.1016/j.cjca.2012.11.033
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Abstract

Cardiovascular magnetic resonance imaging (CMRI) is currently considered part of standard care at many academic centres for the evaluation of patients with ischemic or nonischemic cardiomyopathy. While CMRI provides unparalleled diagnostic versatility for the assessment of myocardial function, perfusion, and tissue health, evidence supporting its prognostic value for the prediction of important cardiovascular events is now emerging. Given the low specificity of currently available clinical markers in patients with cardiomyopathy, more-robust biomarkers aimed at identifying those at high risk of sudden cardiac death and other relevant outcomes are desirable. Late gadolinium enhancement (LGE) CMRI offers the novel capacity to quantify the burden of myocardial fibrosis, a common pathophysiological end point of most cardiomyopathy states. As such, it has the potential to be a robust and ubiquitous marker of cardiovascular events related to the presence of advanced tissue disease. This review paper focuses on the evidence to date supporting LGE imaging as a tool for the prediction of future cardiovascular events in patients with ischemic and nonischemic cardiomyopathy.

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Metadata

Authors
Stirrat, J., & White, J. A.
Affiliations
Western University (CA)
Corresponding author
White, James A.
ORCID
White, James A.
Venue
Canadian Journal of Cardiology
Publisher
Elsevier BV
Published
2013-03
Volume
29
Issue
3
Pages
329-336
ISSN
0828-282X (ISSN-L)
DOI
10.1016/j.cjca.2012.11.033
OpenAlex
W1989443948
Cited by
33
References
66
Citations by year
2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 6 · 2016: 1 · 2015: 5 · 2014: 1 · 2013: 4
FWCI
0.52
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Canadian Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Bayer Canada
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
late gadolinium enhancement, cardiovascular magnetic resonance imaging, cardiomyopathy, myocardial fibrosis, prognosis, sudden cardiac death, ischemic cardiomyopathy, non-ischemic cardiomyopathy, cardiovascular event prediction, prognostic factors
MeSH terms
Contrast Media, Gadolinium, Humans, Magnetic Resonance Imaging, Cardiomyopathies, Predictive Value of Tests, Prognosis, Risk Factors, Sensitivity and Specificity, Risk Assessment

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