Beneficial effects of virgin coconut oil on lipid parameters and in vitro LDL oxidation
Abstract
Objectives The present study was conducted to investigate the effect of consumption of virgin coconut oil (VCO) on various lipid parameters in comparison with copra oil (CO). In addition, the preventive effect of polyphenol fraction (PF) from test oils on copper induced oxidation of LDL and carbonyl formation was also studied. Design and methods After 45 days of oil feeding to Sprague-Dawley rats, several lipid parameters and lipoprotein levels were determined. PF was isolated from the oils and its effect on in vitro LDL oxidation was assessed. Results VCO obtained by wet process has a beneficial effect in lowering lipid components compared to CO. It reduced total cholesterol, triglycerides, phospholipids, LDL, and VLDL cholesterol levels and increased HDL cholesterol in serum and tissues. The PF of virgin coconut oil was also found to be capable of preventing in vitro LDL oxidation with reduced carbonyl formation. Conclusion The results demonstrated the potential beneficiary effect of virgin coconut oil in lowering lipid levels in serum and tissues and LDL oxidation by physiological oxidants. This property of VCO may be attributed to the biologically active polyphenol components present in the oil.
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Daily consumption of 30 mL of wet-process VCO showed advantageous effects on lipid profiles compared to copra oil, lowering phospholipids, cholesterol, total triglycerides, VLDL, and LDL cholesterol levels while increasing HDL cholesterol in tissues and serum.
“Daily consumption of 30 mL of VCO showed advantageous effects on lipid profiles compared to copra oil, lowering phospholipids, cholesterol, total triglycerides, VLDL, and LDL cholesterol levels while increasing HDL cholesterol in tissues and serum.”
From Nutritional composition and bioactive properties of tropical coconut palm fruit with functional food applications (2025) · cites this paper as [149]
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References 41 · Cited by 366
- Authors
- Nevin, K. G., & Rajamohan, T.
- Affiliations
- University of Kerala (IN)
- Corresponding author
- Rajamohan, T.
- Venue
- Clinical Biochemistry
- Publisher
- Elsevier BV
- Published
- 2004-09
- Volume
- 37
- Issue
- 9
- Pages
- 830-835
- ISSN
- 0009-9120 (ISSN-L)
- OpenAlex
- W2170129602
- Cited by
- 366
- References
- 41
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 21 · 2023: 14 · 2022: 21 · 2021: 30 · 2020: 28 · 2019: 31 · 2018: 31 · 2017: 22 · 2016: 18 · 2015: 22 · 2014: 18 · 2013: 25 · 2012: 14
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Inorganic Chemistry › Coconut Research and Applications
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- virgin coconut oil, copra oil, lipid profile, LDL oxidation, polyphenols, copper-induced oxidation, carbonyl formation, cholesterol, HDL cholesterol, VLDL cholesterol, triglycerides, dietary fat
- MeSH terms
- Coconut Oil, Animals, Cholesterol, Cocos, Dietary Fats, Cholesterol, LDL, Male, Plant Extracts, Plant Oils, Lipid Peroxidation, Rats, Sprague-Dawley, Rats
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