Reference range of thyroid hormones in healthy school-age children: Country-wide data from India
Abstract
Objective This study was planned to obtain normative data of thyroid functions in school-age children from different regions of India.Design and methods Students from 36 schools involving 13 states across four geographical zones of India were evaluated for goiter. Subjects who consented, underwent evaluation for serum FT3, FT4, TSH, anti-TPO antibodies and thyroid ultrasound. From this, a "reference population" was obtained by excluding those with personal or family history of thyroid disease, use of thyroid medications, goiter, hypoechogenicity or nodularity on ultrasound or positive anti-thyroid antibodies.Results Of 24,685 students clinically evaluated, 8665 formed part of the study. The reference population comprised 5343 subjects. The mean, median, 3rd and 97th percentiles of FT3, FT4 and TSH for each year (6-17 years) were obtained.Conclusions This community based study in Indian school-age children provides reference intervals for thyroid hormones and evidence against narrowing the TSH reference range.
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In Indian children of a similar age group, FT3 and FT4 showed an inverse association with age, although this relationship was only significant in girls.
“In Indian children of a similar age group FT3 and FT4 also showed an inverse association with age, although this relationship was only significant in girls [47, 48].”
From Age-related variation in thyroid function – a narrative review highlighting important implications for research and clinical practice (2023) · cites this paper as [48]
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References 18 · Cited by 27
- Authors
- Marwaha, R. K., Tandon, N., Desai, A. K., Kanwar, R., Aggarwal, R., Sastry, A., Singh, S., Narang, A., Ganguly, S. K., & Mani, K.
- Affiliations
- Institute of Nuclear Medicine & Allied Sciences (IN)
- All India Institute of Medical Sciences (IN)
- Corresponding author
- Marwaha, Raman K.
- Venue
- Clinical Biochemistry
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 43
- Issue
- 1-2
- Pages
- 51-56
- ISSN
- 0009-9120 (ISSN-L)
- OpenAlex
- W1987401311
- Cited by
- 27
- References
- 18
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2019: 2 · 2018: 1 · 2017: 5 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 2
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Keywords
- thyroid hormones, reference values, elementary school students, free thyroxine, free triiodothyronine, thyroid-stimulating hormone, thyroid peroxidase antibodies, goiter, India
- MeSH terms
- Adolescent, Adult, Child, Female, Goiter, Humans, India, Male, Reference Values, Schools, Thyroid Gland, Thyroxine, Triiodothyronine
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