Serum Retinol-Binding Protein 4 (RBP4) and retinol in a cohort of borderline obese women with and without gestational diabetes
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Objectives To evaluate whether serum RBP4 correlates with gestational diabetes mellitus (GDM) in a cohort of borderline obese (BMI>30) pregnant women. Design and methods Serum RBP4 and retinol were measured in pregnant women with (n=12) and without (n=10) GDM. Results RBP4, retinol and RBP4:retinol molar ratio were not different between the groups and were not associated with markers of insulin resistance. Conclusions GDM is not associated with RBP4 or retinol among borderline obese pregnant women.
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There is no relationship between vitamin A and GDM in pregnant women with a BMI > 30 kg/m2.
“A cohort study reported no relationship between vitamin A and GDM in pregnant women with a BMI > 30 kg/m2 [127].”
From Medical Nutrition Therapy for Women with Gestational Diabetes: Current Practice and Future Perspectives (2025) · cites this paper as [127]
The Results report no difference in serum retinol (vitamin A) between women with and without GDM, and the Discussion describes no significant association in this cohort. The Results give an average BMI of 31 kg/m² for each group, but do not establish that every participant had a BMI above 30; the GDM cases were also mild. The claim therefore states the BMI condition more precisely than the paper supports. (LLM, conf=0.82)
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References 14 · Cited by 31
Research works printed but not linked: 12
- [1]Quadro L Hamberger L Colantuoni V Gottesman M Blaner WS Understanding the Physiological Role of Retinol-Binding Protein in Vitamin A Metabolism Using Transgenic and Knockout Mouse Models Mol Aspect Med 2003 24 421 430 14585313
- [3]Graham TE Yang Q Bluher M Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects N Engl J Med 2006 354 2552 2563 16775236
- [4]Lewis JG Shand BI Frampton CM Elder PA Scott RS Plasma retinol-binding protein is not a marker of insulin resistance in overweight subjects: a three year longitudinal study Clin Biochem 2008 41 1034 1038 18588869
- [5]Butte NF Carbohydrate and lipid metabolism in pregnancy: normal compared with gestational diabetes mellitus Am J Clin Nutr 2000 71 1256S 1261S 10799399
- [6]Kim S-H Choi H-J Retinol-binding protein 4 responses during an oral glucose tolerance testing in women with gestational diabetes mellitus Clin Chim Acta 2007 391 123 125 18328819
- [7]Chan TF Chen HS Chen YC Increased serum retinol-binding protein 4 concentrations in women with gestational diabetes mellitus Reprod Sci 2007 14 169 174 17636228
- [8]Lewandowski KC Stojanovic N Bienkiewicz M Elevated concentrations of retinol-binding protein-4 (RBP-4) in gestational diabetes mellitus: negative correlation with soluble vascular cell adhesion molecule-1 (sVCAM-1) Gynecol Endocrinol 2008 24 300 305 18584408
- [9]Krzyzanowska K Zemany L Krugluger W Serum concentrations of retinol-binding protein 4 in women with and without gestational diabetes Diabetologia 2008 51 1115 1122 18437353 PMC2676863
- [10]Kloting N Graham TE Berndt J Serum retinol-binding protein is more highly expressed in visceral than in subcutaneous adipose tissue and is a marker of intra-abdominal fat mass Cell Metab 2007 6 79 87 17618858
- [11]Tschoner A Sturm W Engl J Retinol-binding protein 4, visceral fat, and the metabolic syndrome: effects of weight loss Obesity (Silver Spring) 2008 16 2439 2444 18719670
- [13]Quadro L Blaner WS Hamberger L Muscle expression of human retinol-binding protein (RBP). Suppression of the visual defect of RBP knockout mice J Biol Chem 2002 277 30191 30197 12048218
- [14]Graham TE Wason CJ Bluher M Kahn BB Shortcomings in methodology complicate measurements of serum retinol binding protein (RBP4) in insulin-resistant human subjects Diabetologia 2007 50 814 823 17294166
- Authors
- Tepper, B. J., Kim, Y.-K., Shete, V., Shabrova, E., & Quadro, L.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Quadro, Loredana
- Venue
- Clinical Biochemistry
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 43
- Issue
- 3
- Pages
- 320-323
- ISSN
- 0009-9120 (ISSN-L)
- PMC
- PMC2812612
- OpenAlex
- W2066475420
- Cited by
- 31
- References
- 14
- Citations by year
- 2025: 1 · 2024: 4 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 2 · 2015: 5 · 2014: 3 · 2013: 2 · 2012: 1
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Deafness and Other Communication Disorders (R01DC004702, DC04702)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD057493, HD057493)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- retinol-binding protein 4, retinol, gestational diabetes mellitus, pregnancy, insulin resistance, adipokines, vitamin A
- MeSH terms
- Adult, Animals, Blood Glucose, Female, Humans, Insulin, Obesity, Pregnancy, Vitamin A, Diabetes, Gestational, Leptin, Retinol-Binding Proteins, Plasma, Young Adult
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